A5023699740- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Epigenetics and DNA Methylation
- Effects and risks of endocrine disrupting chemicals
- Per- and polyfluoroalkyl substances research
- Head and Neck Cancer Studies
- Noise Effects and Management
- RNA modifications and cancer
- Birth, Development, and Health
- Health, Environment, Cognitive Aging
- Metabolism and Genetic Disorders
- Air Quality Monitoring and Forecasting
- Urban Transport and Accessibility
- Global Health Care Issues
- Gestational Diabetes Research and Management
- Single-cell and spatial transcriptomics
- Health disparities and outcomes
- Heavy Metal Exposure and Toxicity
- Energy and Environment Impacts
- Toxic Organic Pollutants Impact
- Immune Cell Function and Interaction
- Respiratory viral infections research
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- Carcinogens and Genotoxicity Assessment
Brown University
2015-2024
John Brown University
2013-2024
Navitas Systems (United States)
2023-2024
Providence College
2014-2018
Women & Infants Hospital of Rhode Island
2018
University of Connecticut
2012-2014
Institute of Aging
2014
Orszagos Kornyezetegeszsegugyi Intezet
2014
Hebrew SeniorLife
2012-2014
University of Minnesota
2013
<h3>Importance</h3> The neutrophil-to-lymphocyte ratio (NLR) is associated with mortality and cardiovascular disease at the time of incident disease, but it not known whether this true in prospective studies. Further, a common genetic variant African origin relative neutropenia, Duffy antigen variant, candidate to modify associations between NLR outcomes. <h3>Objective</h3> To investigate association cardiovascular-related outcomes Jackson Heart Study (JHS) validated our findings Normative...
Exposure to ambient air pollution, particularly from traffic, has been associated with adverse cognitive outcomes, but the association depressive symptoms remains unclear. We investigated between exposure and traffic pollution presence of among 732 Boston-area adults ≥ 65 years age (78.1 ± 5.5 years, mean SD). assessed during home interviews using Revised Center for Epidemiological Studies Depression Scale (CESD-R). estimated residential distance nearest major roadway as a marker long-term...
Although HPV16 has been strongly implicated in oropharyngeal carcinogenesis, the role of other high‐risk HPV types etiology head and neck cancer remains unclear. To date, few data exist addressing nature association between antibodies to oncogenic proteins non‐HPV16 HPVs relation cancer. We examined relationship multiple (HPV6, 11, 16, 18, 31, 33, 45, 52, 58) squamous cell carcinoma (HNSCC) a large population‐based case–control study (1069 cases 1107 controls). Serological measures for...
Tobacco smoking is a risk factor for multiple diseases, including cardiovascular disease and diabetes. Many smoking-associated signals have been detected in the blood methylome, but extent to which these changes are widespread metabolically relevant tissues, impact gene expression or metabolic health, remains unclear. We investigated DNA methylation variation adipose tissue biopsies from 542 healthy female twins. Replication, specificity, longitudinal stability of effects were explored...
Days of extreme temperature may be associated with transiently higher risk preterm birth, but prior studies have been limited and results heterogeneous. To evaluate the association between days heat cold birth among ~32 million live singleton births 1989 2002 across 403 counties in contiguous United States (US). We used a distributed lag nonlinear model to estimate population-weighted daily mean each county then pooled geographic regions climate zones. defined as 95th 5th percentile...
The variability and predictors of urinary concentrations phthalate metabolites in preschool-aged children have not been thoroughly examined. Additionally, the impact temporal changes use restriction phthalates children's products has assessed. Our objective was to identify demographic, behavioral, metabolite young children. Between 2004 2011, we collected up five urine samples from each 296 participating a prospective birth cohort during annual study visits at ages 1-5 years. We used linear...
Organophospate flame retardants (PFRs) are chemicals of emerging concern due to restrictions on polybrominated diphenyl ether retardant formulations. We describe the occurrence, variability, and predictors urinary metabolites PFRs among pregnant women. In 2014–2015, 59 women from Providence, RI provided up 3 spot urine samples during pregnancy (~12, 28, 35 weeks' gestation). created a pooled sample per woman measured nine relevant in individual samples. used linear mixed models calculate...
Background: DNA methylation alterations may underlie associations between gestational perfluoroalkyl substances (PFAS) exposure and later-life health outcomes. To the best of our knowledge, no longitudinal studies have examined PFAS methylation. Objectives: We with measures at birth in adolescence using Health Outcomes Measures Environment (HOME) Study (2003–2006; Cincinnati, Ohio). Methods: quantified serum concentrations perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS),...
Background:Climate change is expected to cause increases in heat-related mortality, especially among the elderly and very young. However, additional studies are needed clarify effects of heat on morbidity across all age groups a wider range temperatures.Objectives:We aimed estimate impact current projected future temperatures mortality Rhode Island.Methods:We used Poisson regression models association between daily maximum temperature rates all-cause emergency department (ED) admissions...
Abstract Current studies suggesting that smokeless tobacco use increases the risk of head and neck cancer are hampered by small numbers. Consequently, there remains uncertainty in magnitude significance this risk. We examined relationship between squamous cell carcinoma (HNSCC) a population‐based case–control study with 1,046 cases 1,239 frequency‐matched controls. Logistic regression models were used to estimate odds ratios (OR) 95% confidence intervals (95% CI), adjusting for age, gender,...
Gastric reflux can reach into the upper airway, inducing cellular damage in epithelial lining. This condition is believed to be a risk factor for development of laryngopharyngeal squamous cell carcinoma (LPSCC), although literature conflicting.To better clarify this relationship, we assessed association self-reported heartburn history and medication use among 631 patients with LPSCCs 1234 control subjects (frequency-matched on age, gender, town residence) enrolled as part population-based...
Natural killer (NK) cells are now recognized to exhibit characteristics akin of the adaptive immune system. The generation memory is linked epigenetic reprogramming including alterations in DNA methylation. study herein found reproducible genome wide methylation changes associated with human NK cell activation. Activation led predominately CpG hypomethylation (81% significant loci). Bioinformatics analysis confirmed that non-coding and gene-associated differentially methylated sites (DMS)...