A5008395418- Effects and risks of endocrine disrupting chemicals
- Functional Brain Connectivity Studies
- Health, Environment, Cognitive Aging
- Breastfeeding Practices and Influences
- Autism Spectrum Disorder Research
- Advanced Neuroimaging Techniques and Applications
- Family and Disability Support Research
- Air Quality and Health Impacts
- Child Nutrition and Feeding Issues
- Per- and polyfluoroalkyl substances research
- Schizophrenia research and treatment
- Gestational Diabetes Research and Management
- Child Development and Digital Technology
- Child Nutrition and Water Access
- Birth, Development, and Health
- Climate Change and Health Impacts
- Neural dynamics and brain function
- Noise Effects and Management
- Arsenic contamination and mitigation
- Heavy Metal Exposure and Toxicity
- Complementary and Alternative Medicine Studies
- Pain Management and Placebo Effect
- Neuroscience and Music Perception
- Cognitive and developmental aspects of mathematical skills
- Cerebral Venous Sinus Thrombosis
Brown University
2019-2025
Drexel University
2023-2024
Autism & Developmental Medicine Institute
2017-2022
John Brown University
2019-2020
Linear regression is often used to estimate associations between chemical exposures and neurodevelopment at the mean of outcome. However, potential effect chemicals may be greater among individuals ‘tails’ outcome distributions. Here, we investigated distributional effects on gestational phthalate exposure child Autism Spectrum Disorder (ASD)-related behaviors using quantile regression. We harmonized data from Early Risk Longitudinal Investigation (EARLI) (n = 140) Study, an enriched-risk...
Background Evaluating individual health outcomes does not capture co-morbidities children experience. Purpose We aimed to describe profiles of child neurodevelopment and anthropometry identify their predictors. Methods Using data from 501 mother-child pairs (age 3-years) in the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, a prospective cohort study, we developed phenotypic by applying latent profile analysis twelve neurodevelopmental anthropometric traits. multinomial...
Thyroid hormones are essential for neurodevelopment. Few studies have considered associations with quantitatively measured autism spectrum disorder (ASD)-related traits, which may help elucidate a broader population. Participants were drawn from two prospective pregnancy cohorts: the Early Autism Risk Longitudinal Investigation (EARLI), enrolling pregnant women who already had child ASD, and Health Outcomes Measures of Environment (HOME) Study, following greater Cincinnati, OH area....
Atypical sulcogyral patterns in the orbitofrontal cortex (OFC) are associated with increased risk for schizophrenia, as well quantitative traits such anhedonia. Here we conduct a cross-diagnostic comparison to assess whether atypical OFC confer multiple brain disorders. We examined structural images from 4 groups of adult participants (N = 189), including those diagnosed schizophrenia (SZ; N 49), bipolar disorder (BP; 46), attention deficit hyperactivity (ADHD; 41), and controls 53). pattern...
Abstract Understanding the factors that drive organization and function of brain is an enduring question in neuroscience. Using functional magnetic resonance imaging (fMRI), structure have been mapped primary sensory cortices based on knowledge organizational principles likely a given region (e.g., aspects visual form cortex sound frequency auditory cortex) underlying cytoarchitecture. The organizing higher‐order areas encode more complex signals, such as orbitofrontal (OFC), are less well...
Abstract Evidence suggests core autism trait consistency in older children, but development of these traits is variable early childhood. The Social Responsiveness Scale (SRS) measures autism‐related and broader phenotype, with two age‐dependent forms childhood (preschool, 2.5–4.5 years; school age, 4–18 years). Score has been observed within forms, though reliability across not evaluated. Using data from the Environmental Influences on Child Health Outcomes (ECHO) program ( n = 853),...
Maternal nutrition during gestation has been investigated for its role in child neurodevelopment. However, little is known about the potential impact of gestational caffeine exposure on autistic behaviors. Here, we assess relation between maternal intake pregnancy and children’s behavioral traits related to Autism Spectrum Disorder (ASD). We harmonized data from two cohorts, Early Risk Longitudinal Investigation (EARLI) (n = 120), an enriched-risk cohort mothers who previously had a with...
Abstract Purpose Prior work developed a shortened 16-item version of the Social Responsiveness Scale (SRS), quantitative measure social communication and autism spectrum disorder (ASD)-related traits. However, its properties for use in risk factor estimation have not been fully tested compared to full SRS. We associations between gestational age (previously established ASD) 65-item “full” “short” versions SRS test version’s ability capture epidemiologic analyses ASD factors. Methods used...
Abstract Objective Excessive gestational weight gain (GWG) has been associated with autism spectrum disorder (ASD). This study sought to examine whether familial susceptibility for autism, intensity of ASD‐related behaviors, or prepregnancy BMI influences the association GWG behaviors. Methods Using data from Early Autism Risk Longitudinal Investigation (EARLI) ( n = 136), a enriched cohort mothers who had previous child ASD, and Health Outcomes Measures Environment (HOME) 253), general...
Gestational arsenic exposure adversely impacts child health. Folate-mediated 1-carbon metabolism facilitates urinary excretion of and may prevent arsenic-related adverse health outcomes. We investigated the potential for maternal folate status to modify associations between gestational used data from 364 mother–child pairs in MIREC study, a prospective pan-Canadian cohort. During pregnancy, we measured first trimester concentrations, plasma biomarkers, folic acid supplementation intake. At...
Abstract Frequencies of orbitofrontal cortex (OFC) sulcogyral patterns in populations, with less common identified at higher rates among those psychopathology. Previous work has assumed demographic characteristics have no influence on OFC patterns. However, the sociodemographic and health-related within a neurotypical population not been formally evaluated. We used structural brain magnetic resonance imaging (MRI) from cohort Human Connectome Project (HCP) existing characterizations (n=238);...