A5004043864- Child and Adolescent Psychosocial and Emotional Development
- Early Childhood Education and Development
- Systemic Sclerosis and Related Diseases
- Maternal Mental Health During Pregnancy and Postpartum
- Infant Development and Preterm Care
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Child Nutrition and Feeding Issues
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Substance Abuse Treatment and Outcomes
- Mental Health Research Topics
- Eating Disorders and Behaviors
- Obesity, Physical Activity, Diet
- Mental Health and Psychiatry
- Pancreatitis Pathology and Treatment
- Child Abuse and Trauma
- Youth Development and Social Support
- Endoplasmic Reticulum Stress and Disease
- Mind wandering and attention
- Psychiatric care and mental health services
- Fatty Acid Research and Health
- Air Quality and Health Impacts
- Neural and Behavioral Psychology Studies
- Birth, Development, and Health
University of Pittsburgh
2016-2025
Allen Institute for Brain Science
2023
Icahn School of Medicine at Mount Sinai
2023
Case Western Reserve University
2019-2022
Children's Hospital of Pittsburgh
2012-2016
University of Pittsburgh Medical Center
2012-2016
The purpose of this study was to evaluate the presence and levels interferon-gamma inducible protein-10 (IP-10) in plasma skin pediatric localized scleroderma (LS) patients compared those healthy controls determine if IP-10 correlate clinical disease activity measures. analyzed using a Luminex panel 69 with LS 71 controls. Of these patients, five had available biopsy specimens concurrent serological data during active phase, which were used analyze location by immunohistochemistry (IHC)....
Although theoretical models highlight the role of coping motivations in promoting co-development depression and alcohol use, few longitudinal studies have examined such processes across early adulthood. The current study association between use late adolescence A control sample adolescents (N = 498) from a prevention trial completed Brief Symptom Inventory, Life Events Coping self-report survey on at ages 17, 22, 23, as well Composite International Diagnostic Interview age 28-30. Path...
Over the last decades, interdisciplinary field of affective sciences has seen proliferation rather than integration theoretical perspectives. This is due to differences in metaphysical and mechanistic assumptions about human phenomena (what they are how work) which, shaped by academic motivations values, have determined constructs operationalizations. An assumption on purpose phenomenacan be used as a teleological principle guide construction common set assumptions—a framework for research....
Paediatric localized scleroderma (LS) can negatively impact health-related quality of life (HRQoL) by causing skin fibrosis, abnormal limb development, disfigurement, and side-effects from immunosuppressive treatment. Studies to date have rarely included qualitative data gathered directly paediatric patients with LS.To assess the LS on HRQoL among affected youth their caregivers using description.Youth all subtypes were purposively sampled participate in age-appropriate focus groups (younger...
The present study examined prevention effects of the family check-up (FCU) program on longitudinal changes in youth depression, using harmonized data collected across three trials, including one trial initiated early childhood and two adolescence (total N = 2,322).Data from parent reports depression were Moderated Nonlinear Factor Analysis (MNLFA), which provides a robust means to examine differential item functioning (DIF) subgroups participants (e.g., age groups, ethnic groups), creates...
Abstract Evidence suggests core autism trait consistency in older children, but development of these traits is variable early childhood. The Social Responsiveness Scale (SRS) measures autism‐related and broader phenotype, with two age‐dependent forms childhood (preschool, 2.5–4.5 years; school age, 4–18 years). Score has been observed within forms, though reliability across not evaluated. Using data from the Environmental Influences on Child Health Outcomes (ECHO) program ( n = 853),...
Colipase is essential for efficient fat digestion. An arginine-to-cysteine polymorphism at position 92 of colipase (Arg92Cys) associates with an increased risk developing type-2 diabetes through undefined mechanism. To test our hypothesis that the extra cysteine increases misfolding, thereby altering its intracellular trafficking and function, we expressed Cys92 in HEK293T cells. Less secreted more retained intracellularly insoluble form compared Arg92 colipase. Nonreducing gel...
Background: During the period from pregnancy through first year postpartum, vulnerable individuals are at elevated risk for onset or worsening of psychological distress, and accessible (e.g., virtually delivered) mental health interventions needed. Research suggests that Mindfulness-Based Cognitive Therapy (MBCT) can effectively mitigate although few studies have evaluated MBCT in perinatal period, samples been clinically homogenous. Thus, we designed conducting a pilot trial delivered with...
Objective The current study investigated sex differences in longitudinal associations among youth depression, conduct problems, and peer rejection from ages 11 to 16. We hypothesized that girls would follow the irritable depression model, which posits leads mediate this relationship. boys cumulative failure suggests problems predict future mediated by rejection.
We investigated the ability of a panel immune-related cytokines and chemokines to predict disease activity state in localized scleroderma (LS) subjects followed longitudinally. A total 194 sera samples were obtained from 45 LS with diverse types (40% linear, 20% mixed, 16% craniofacial, 13% generalized, 11% circumscribed) our cohort. Cytokines/chemokines that significantly elevated at baseline active visit compared inactive follow-up Interferon-Gamma-Inducible Protein (IP)-10 (p < 0.021)...
The Environmental influences on Child Health Outcomes (ECHO) Cohort has enrolled over 60,000 children to examine how early environmental factors (broadly defined) are associated with key child health outcomes. ECHO may be well-positioned contribute our understanding of rural environments and contexts, which implications for disparities research. present study examined the outcome obesity not only illustrate suitability data these purposes but also determine various definitions urban...