A5081232189- Effects and risks of endocrine disrupting chemicals
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Per- and polyfluoroalkyl substances research
- Nutritional Studies and Diet
- Epigenetics and DNA Methylation
- Obesity, Physical Activity, Diet
- Toxic Organic Pollutants Impact
- Health, Environment, Cognitive Aging
- Fatty Acid Research and Health
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Child Nutrition and Water Access
- Mitochondrial Function and Pathology
- Liver Disease Diagnosis and Treatment
- Telomeres, Telomerase, and Senescence
- Urological Disorders and Treatments
- Cancer Risks and Factors
- Folate and B Vitamins Research
- Air Quality and Health Impacts
- Breastfeeding Practices and Influences
- Sexual Differentiation and Disorders
Michigan State University
2018-2025
Cohort (United Kingdom)
2024
Michigan United
2018-2022
Michigan Department of Agriculture and Rural Development
2022
Food and Nutrition Service
2020
University of Illinois Urbana-Champaign
2008-2017
Unité de Nutrition Humaine
2013
In insulin resistance and type II diabetes, there is an elevation of hepatic gluconeogenesis, which contributes to hyperglycaemia. Studies in experimental animals have provided evidence that consumption high fat (HF) diets by female rats programs the progeny for glucose intolerance adulthood, but mechanisms behind utero programming remain poorly understood. The present study analysed effect a maternal HF diet on fetal gluconeogenic gene expression potential regulation mechanism related...
Pregnant women are exposed to numerous endocrine disrupting chemicals (EDCs) that can affect hormonal pathways regulating pregnancy outcomes and fetal development. Thus, we evaluated overall sex-specific associations of phthalate/replacement, paraben, phenol biomarkers with sex-steroid thyroid hormones. Illinois (n=302) provided plasma for progesterone, estradiol, testosterone, free T4 (FT4), total (TT4), stimulating hormone (TSH) at median 17 weeks gestation. Women also up-to-five...
Per- and polyfluoroalkyl substances (PFAS) can disrupt metabolism. Early-to-mid pregnancy is characterized by amplified metabolic processes inflammation to support maternal adaptations fetal growth. Thus, we cross-sectionally evaluated whether PFAS are individually jointly associated with these in early-to-mid pregnancy. Pregnant Illinois women (n = 452) provided fasted blood samples at median 17 weeks gestation. We quantified serum perfluorononanoic (PFNA), perfluorooctane sulfonic (PFOS),...
The placenta guides fetal growth and development. Bisphenol A (BPA) phthalates are widespread environmental contaminants endocrine disruptors, the placental epigenetic response to these chemicals is an area of growing research interest. Therefore, our objective was summarize linking BPA or phthalate exposure outcomes in human pregnancies, with a particular focus on endpoints. In PubMed, studies were selected for review (without limiting start date ending 1 May 2018) if they reported any...
Pregnant women are ubiquitously exposed to phthalates from food packaging materials and personal care products. Phthalates alter estrogen testosterone concentrations in experimental models, but their ability impact these hormones human pregnancy is not well characterized.We recruited ages 18-40 into the Illinois Kids Development Study (I-KIDS) early pregnancy. Participants provided up 5 first-morning urine samples across (8-40 weeks gestation) that we pooled for quantification of 19...
Uterine leiomyoma is the most common tumor in women and causes severe morbidity 15 to 30% of reproductive-age women. Epidemiological studies consistently indicate a correlation between development exposure endocrine-disrupting chemical phthalates, especially di-(2-ethylhexyl) phthalate (DEHP); however, underlying mechanisms are unknown. Here, among commonly encountered metabolites, we found strongest association urine levels mono(2-ethyl-5-hydroxyhexyl) (MEHHP), principal DEHP metabolite,...
Pregnant women are exposed to multiple phthalates and their replacements, which endocrine disrupting chemicals associated with adverse maternal child health outcomes. Identifying characteristics phthalate/replacement exposure during pregnancy is important. We evaluated 13 sociodemographic lifestyle factors, enrollment year, conception season as determinants of biomarkers replacements in 482 pregnant from the Illinois Kids Development Study (I-KIDS, enrolled 2013-2018). quantified 19...
Importance Limited access to healthy foods, resulting from residence in neighborhoods with low food access, is a public health concern. The contribution of this exposure early life child obesity remains uncertain. Objective To examine associations neighborhood during pregnancy or childhood body mass index (BMI) and risk. Design, Setting, Participants Data cohorts participating the US nationwide Environmental Influences on Child Health Outcomes consortium between January 1, 1994, March 31,...
Overnutrition, such as a high-fat (HF) diet, is feature followed by some in developed nations that leads to obesity and fatty liver disease. In rats, when fed fat-high develop (obesity prone, OP) while others display an obesity-resistant (OR) phenotype. The present study investigated the differences between OP OR rats on their activation of hepatic cellular senescence pathways HF diet. Male were diet containing 45% kcal from fat for 13 wk, livers collected analysis quantitative real-time...
Placenta, as the sole transport mechanism between mother and fetus, links maternal physical state immediate well lifelong outcomes of offspring. The present study examined consequences obesity on placental lipid accumulation metabolism. Pregnant obesity-prone (OP) obesity-resistant (OR) rat strains were fed a control diet throughout gestation. Placentas collected Gestational Day 21 for mRNA oxidative stress analysis, frozen sections analyzed fat beta-catenin Dickkopf homolog 1 (Xenopus...
Phthalate exposure is associated with altered reproductive function, but little known about associations between phthalate and hormone levels in midlife women.
Pregnant women are exposed to numerous endocrine disrupting chemicals (EDCs). Pregnancy-related nausea likely has hormonal etiology and may persist beyond the first trimester. Therefore, we aimed determine relationship between EDC biomarkers pregnancy characteristics. Illinois Kids Development Study (I-KIDS) pregnant (n=467) reported symptoms monthly from conception delivery. We categorized as never having (9%), or typical (ends by 17 weeks gestation; 42%), persistent after 25%), irregular...
Genistein (Gen), the primary isoflavone in soy, has been shown to adversely affect various endocrine-mediated endpoints rodents and humans. Soy formula intake by human infants associated with early age at menarche decreased female-typical behavior girls. Adipose deposition expansion are also hormonally regulated Gen alter these processes. However, little is known about impact of early-life soy on metabolic homeostasis adulthood. The current study examined exposure adulthood body composition...
Prenatal per- and poly-fluoroalkyl substances (PFAS) exposure may influence gestational outcomes through bioactive lipids─metabolic inflammation pathway indicators. We estimated associations between prenatal PFAS lipids, measuring 12 serum 50 plasma lipids in 414 pregnant women (median 17.4 weeks' gestation) from three Environmental influences on Child Health Outcomes Program cohorts. Pairwise association estimates across cohorts were obtained linear mixed models meta-analysis, adjusting the...
Women are ubiquitously exposed to endocrine disruptors, including phthalates. Ovarian follicles undergoing folliculogenesis (indirectly measured by ovarian volume) produce anti-Müllerian hormone (AMH) and estradiol (E2). We evaluated associations of phthalates with volume assess whether this explained prior positive AMH E2.