Vulvovaginal candidiasis (VVC) remains one of the most common infections female genital tract. Correct identification isolated Candida species is essential to direct empirical antifungal therapy. Objectives: This local study was conducted identify spectrum associated with VVC using different phenotypic and genotypic methods assess their susceptibility pattern. Materials methods: High vaginal swabs were collected from 125 patients presenting a clinical picture suggestive VVC. Swabs subjected...

Background Vulvovaginal candidiasis (VVC) is a highly prevalent illness affecting women globally. Lactobacilli, which make up the majority of healthy vaginal microbiota (VMB), serve as powerful barrier against infections. Probiotic therapy has been recommended for treatment or prevention VVC. Aim work To compare in vivo therapeutic effects Lactobacillus johnsonii (B-2178) vs. acidophilus (LA-5 ® ) on VVC rat model, particularly highlighting immune response host epithelium. Methods In total,...

Background. The global incidence of carbapenem-resistant Enterobacterales (CRE) is increasing, posing a major treatment challenge and serious infection control concern. Objective. We aimed to characterize carbapenemases both genotypically phenotypically among CRE isolated from two tertiary hospitals in Egypt, detect the genetic relatedness studied isolates. Methodology. A total 107 non-duplicate strains different clinical specimens hospitalized patients were assessed for presence genes using...

Introduction Lupus nephritis (LN) is one of the most prevalent severe organ manifestations systemic lupus erythematosus (SLE), impacting 70% SLE patients. MicroRNAs (miRNAs), are small non-coding RNA molecules which influence expression approximately one-third human genes after process transcription. Dysregulation miRNAs was documented in numerous disorders, including and LN. Cytokines orchestrators immune response autoimmune diseases. Our study aims to explore variation levels circulating...

We aimed to assess the knowledge and attitude of Saudi population students health science colleges as well healthcare workers in Riyadh city about organ donation (OD). Data this study were collected from 648 residents using interviewer-administered questionnaires online surveys. The participants included 503 general 145 professionals. subjects 252 males 396 females with mean age 27.09 ± 9 years. Majority (60%) aware OD media main source information, while only 30% had center for...

Uropathogenic Escherichia coli (UPEC) is the most common cause of urinary tract infections (UTIs) in hospitalised and non-hospitalised patients. Genomic analysis was used to gain further insight into molecular characteristics UPEC isolates from Saudi Arabia. A total 165 were collected patients with UTIs between May 2019 September 2020 two tertiary hospitals Riyadh, Identification antimicrobial susceptibility testing (AST) performed using VITEK system. Extended-spectrum β-lactamase...

Background: Methicillin-resistant Staphylococcus aureus (MRSA) infection remains a challenging threat because of limited treatment options. Ceftaroline was identified as having potent anti-MRSA activity. Aim: To evaluate the susceptibility MRSA to gentamicin, macrolides, ciprofloxacin, vancomycin, and ceftaroline perform molecular characterization different resistance genes aminoglycoside modifying enzyme genes, ermA ermC, vanA vanB genes. Patients Methods: One hundred non-duplicate strains...

To detect the incidence of and risk factors for infections among patients with end-stage renal disease (ESRD) undergoing peritoneal dialysis (PD).A retrospective cohort study was conducted at PD unit King Fahad Medical City. End-stage above age 12 years who were management between January 2006 March 2016 included.One hundred enrolled in examined over a total observation period 2,553 patient-months. The leading ESRD etiology hypertension (26.3%). mean duration 28.05 months. A 45 developed 101...

Background: Various virulence factors are contributing to the colonization and pathogenicity of  Candida during both superficial systemic infections Objectives: The current study was conducted investigate production of extracellular hydrolytic enzymes, hemolysis biofilm formation among species isolated from versus candidiasis compare these albicans non-albicans species, in addition comparing enzymes under aerobic anaerobic conditions. Methodology: A total 51 strains vulvovaginal 44 were...

Abstract BACKGROUND: The most cost-effective measure for preventing the infectious disease, influenza, is vaccination. purpose of this research was to evaluate knowledge levels, familiarity, and attitude toward influenza vaccination Riyadh adult population. MATERIALS AND METHODS: A cross-sectional study carried out in data collected between December 2017 March 2018. Five hundred participants were interviewed person using a closed-ended questionnaire. Participants comprised general...

Background: Cystic fibrosis (CF) is a genetically recessive disease marked by frequent, chronic lung infections that impair function and cause early death. Objectives: our aim was to identify the bacteria colonizing airways among cohort of Egyptian children with CF assess their antimicrobial susceptibility biofilm formation capacity. Methodology: In this cross-sectional study, we assessed prevalence bacterial species 34 pediatric patients CF. The isolated pathogens underwent antibiotic...

Background. Ceftazidime-avibactam (CZA) and meropenem-vaborbactam (MVB) are novel therapeutic options for infections caused by carbapenem-resistant Enterobacterales (CRE). Our study aimed to evaluate the in vitro activity of CZA MVB, against a diverse collection CRE assess accuracy disc diffusion method compared E-test. Methods. 70 isolated from hospitalized patients Egypt were included our study. The susceptibility profiles these isolates MVB determined using E-test methodologies. studied...

Development of multidrug resistance in Uropathogenic Escherichia coli (UPEC) makes treatment Urinary Tract Infections (UTIs) a major challenge. This study was conducted to investigate the effect trans-resveratrol (t-RSV) at subinhibitory concentration (sub-MIC-t-RSV) on phenotypic and genotypic expression virulence factors clinical isolates UPEC develop nanoformulation t-RSV. Fifty-five strains were investigated for presence by methods PCR detection genes. The sub-MIC-t-RSV studied factors....

Background: Colistin is a last therapeutic option for carbapenem-resistant Enterobacterales (CRE) infections. Emergence of plasmid-mediated mcr colistin resistance genes poses potential threat treatment these Integrons are known their central role in antibiotic resistance. Objectives: The aim the study was to survey prevalence mcr-genes and integrons colistin-resistant isolates assess methods susceptibility testing. Methodology: Eighty-six strains isolated from different clinical samples...

Background: Hesitancy toward vaccination is a major problem around the globe with significant public health ramifications.It has increased worldwide. Aim of work:The aim this study to explore level knowledge about and attitude practice childhood vaccines among parents in Riyadh Dammam.Methods: This was cross-sectional questionnaire-based that conducted Dammam from December 2019-January 2020 899 who have children age group 0-17 years old.Results: The mean score studied population 7.76 out 18,...

Background: Imbalance in vaginal microbiota causes infection women mainly reproductive age. This study aimed to determine the microbiological and epidemiological profile of laboratory confirmed infections among Saudi women. Methods: cross-sectional retrospective involved medical records patients with from a private hospital Riyadh, Arabia between January 2015 2019. Results: Among 4300 that were reviewed, 564 (13.1%) had laboratory-confirmed infections. Data was collected about participant’s...