A5066075691- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Bone fractures and treatments
- Total Knee Arthroplasty Outcomes
- Surgical Sutures and Adhesives
- Advanced materials and composites
- Dental Implant Techniques and Outcomes
- Advanced ceramic materials synthesis
- Polymer Surface Interaction Studies
- Hemostasis and retained surgical items
- Hip disorders and treatments
- Hip and Femur Fractures
- Anatomy and Medical Technology
- Organophosphorus compounds synthesis
- Periodontal Regeneration and Treatments
- Dental materials and restorations
- Medical and Biological Sciences
- Orthopedic Infections and Treatments
- Bone health and treatments
- Calcium Carbonate Crystallization and Inhibition
- Metal and Thin Film Mechanics
- Facial Trauma and Fracture Management
- Oral and gingival health research
- Mesenchymal stem cell research
- Silk-based biomaterials and applications
Uppsala University
2018-2024
HSBC Holdings
2024
AnaBio Technologies (Ireland)
2020
Shannon Applied Biotechnology Centre
2017
Stryker (United States)
2003-2007
Stryker (Ireland)
2004-2006
Stryker (Switzerland)
2003
Abstract The purpose of this study was to evaluate the long‐term wear performance alumina matrix composite (AMC) heads against inserts and (Al) with use a hip‐joint simulator incorporating severe swing phase joint microseparation. AMC on Al produced an average rate 0.61 mm 3 /million cycles over 5‐million‐cycle test duration. 0.16 Both significantly lower than previously tested HIPed alumina, where 1.84 reported 5 million cycles. mechanisms debris were similar those observed in previous...
Calcium phosphate cements (CPCs) are clinically effective void fillers that capable of bridging calcified tissue defects and facilitating regeneration. However, CPCs completely synthetic/inorganic, unlike the calcium is found in tissues, they lack an architectural organization, controlled assembly mechanisms, have moderate biomechanical strength, which limits their clinical effectiveness. Herein, we describe a new class bioinspired can glue tissues together bond to metallic polymeric...
In this paper we report the synthesis of a library phospho-amino acid analogues, via novel single-step allyl-phosphoester protection/Pd-mediated deprotection strategy. These phosphoserine and phosphotyrosine analogues were then applied as additives to create adhesive calcium phosphate cements, allowing us probe chemical origins increased surface binding strength. We demonstrate importance multiple motifs in mediating adhesion, well highlighting crucial role played by substrate hydrophobicity...
Currently there are no standard models with which to evaluate the biomechanical performance of calcified tissue adhesives, in vivo. We present, herein, a pre-clinical murine distal femoral bone model for evaluating adhesives intended use both osseous and osteochondral reconstruction. Cylindrical cores (diameter (Ø) 2 mm (mm) × depth), containing cancellous cortical bone, were fractured out from femur then reattached using one two adhesives. The adhesiveness fibrin glue (Tisseeltm), novel,...
The aim of the present study was to evaluate soft tissue bond strength a newly developed, monomeric, biomimetic, adhesive called phosphoserine modified cement (PMC). Two types PMCs were evaluated using lap shear (LSS) testing, on porcine skin: calcium metasilicate (CS1), and alpha tricalcium phosphate (αTCP) PMC. CS1 PCM bonded strongly skin, reaching peak LSS 84, 132, 154 KPa after curing for 0.5, 1.5, 4 h, respectively. Cyanoacrylate fibrin glues reached an 207 kPa 33 kPa, αTCP final ≈110...
Abstract A new class of materials, bone adhesives, could revolutionise the treatment highly fragmented fractures. We present first biological safety investigation a bio-inspired adhesive. The formulation was based upon modified calcium phosphate cement that included amino acid phosphoserine. This material has recently been described as substantially stronger than other bioresorbable cements. Four adhesive groups with active substance (phosphoserine) and two control without phosphoserine were...
Osteoporotic fractures are a growing issue due to the increasing incidence of osteoporosis worldwide. High reoperation rates in osteoporotic call for investigation into new methods improving fixation bones. In present study, strength recently developed bone bioadhesive, OsStictm, was evaluated vivo using novel core assay murine animal model at 0, 3, 7, 14, 28, and 42 days. Histology micro-CT were obtained all time points, mean peak pull-out force assessed on days 0-28. The adhesive provided...
The fixation of small intraarticular bone fragments is clinically challenging and an obvious first orthopaedic indication for effective adhesive. In the present study feasibility bonding freshly harvested human trabecular with OsSticR, a novel phosphoserine modified cement, was evaluated using cylinder model pull-out test compared commercial fibrin tissue adhesive.Femoral heads (n=13) were collected from hip fracture patients undergoing arthroplasty stored refrigerated overnight in saline...
Phosphoserine-modified cements (PMCs) are a family of wet-field tissue adhesives that bond strongly to bone and biomaterials. The present study evaluated variations in the adhesive strength using scatter plot, failure mode, regression analysis eleven factors. All single-factor, continuous-variable correlations were poor (R2 < 0.25). linear model explained 31.6% variation = 0.316 p 0.001), with thickness predicting an 8.5% reduction per 100 μm increase. Interestingly, PMC was insensitive...
The aim of this work was to assess the mixing, transfer and handling, properties, injectability, set time, wash-out characteristics, acceptance hardware (i.e. stainless screws), their delivery/transfer systems self hardening synthetic bone cements made from calcium phosphate sulphate. Surgical procedures cranioplasty) were performed on adult Labrador dogs using seven different various manufacturers. Direct comparison defined intraoperative properties evaluated recorded. There is considerable...
Surgeons treating fractures with many small osteochondral fragments have often expressed the clinical need for an adhesive to join such fragments, as adjunct standard implants. If would maintain alignment of articular surfaces and subsequently heal it could result in improved outcomes. However, there are no bone adhesives available indications few pre-clinical models assess safety efficacy biomaterial candidates. A candidate based on water, α-TCP amino acid phosphoserine was evaluated...
The first workshop on the "latest advances in biomedical applications of octacalcium phosphate (OCP)" was organized as a satellite symposium to Bioceramics33 conference Solothurn, Switzerland, October 2023. event brought together leading researchers and industry representatives present discuss their latest groundbreaking research aimed at developing commercializing advanced OCP-based biomaterials for bone regeneration. topics presented by six invited speakers ranged from fundamental...
We report the synthesis of a library phospho-amino acid analogues using novel allyl-phosphoester deprotection strategy. By reacting phenols and alcohols with combination POCl3 allyl alcohol we generate protected phosphoesters that can be subsequently deprotected via treatment Pd(OAc)2. go on to show generated phosphoserine phosphotyrosine used adhesive calcium phosphate cements potential applications in bone defects. In particular, use mechanical testing demonstrate importance multiple...
We report the synthesis of a library phospho-amino acid analogues using novel allyl-phosphoester deprotection strategy. By reacting phenols and alcohols with combination POCl3 allyl alcohol we generate protected phosphoesters that can be subsequently deprotected via treatment Pd(OAc)2. go on to show generated phosphoserine phosphotyrosine used adhesive calcium phosphate cements potential applications in bone defects. In particular, use mechanical testing demonstrate importance multiple...