A5101670186- Natural product bioactivities and synthesis
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Natural Antidiabetic Agents Studies
- Biochemical Analysis and Sensing Techniques
- Fermentation and Sensory Analysis
- Calcium signaling and nucleotide metabolism
- Plant biochemistry and biosynthesis
- Phytochemistry and Biological Activities
- Sirtuins and Resveratrol in Medicine
- Advances in Cucurbitaceae Research
- Traditional Chinese Medicine Analysis
- GABA and Rice Research
- Curcumin's Biomedical Applications
- Melanoma and MAPK Pathways
- Sesquiterpenes and Asteraceae Studies
- Advanced Glycation End Products research
- Biological Activity of Diterpenoids and Biflavonoids
- Occupational and environmental lung diseases
- Monoclonal and Polyclonal Antibodies Research
- Ion Channels and Receptors
- Muscle activation and electromyography studies
- Glycosylation and Glycoproteins Research
- Plant Toxicity and Pharmacological Properties
- Thyroid Cancer Diagnosis and Treatment
Guangdong Polytechnic of Science and Technology
2024
Shandong First Medical University
2022-2023
Shenyang Pharmaceutical University
2021-2023
Wuyi University
2022-2023
Shandong Provincial QianFoShan Hospital
2019-2023
Creative Commons
2023
Wuyi University
2023
Zhejiang University
2023
Shandong University
2019-2022
Qilu Hospital of Shandong University
2021-2022
In this article, a series of betulinic acid derivatives (3a∼3u, 4a∼4e) were synthesized through stepwise structure optimization and evaluated for their anti-α-glucosidase activities. All exhibited stronger activities (IC50: 0.56 ± 0.05 ∼ 3.99 0.23 μM) than 7.21 0.58 acarbose 611.45 15.51 μM). Compound 3q presented the outstanding inhibitory activity μM), which was ∼1100 time that acarbose. revealed as reversible noncompetitive α-glucosidase inhibitor by mechanism assay. Fluorescence spectra,...
Different oleanolic acid (OA) oxime ester derivatives (3a-3t) were designed and synthesised to develop inhibitors against α-glucosidase α-amylase. All the OA evaluated α-amylase in vitro. Among them, compound 3a showed highest inhibition with an IC50 of 0.35 µM, which was ∼1900 times stronger than that acarbose, meanwhile 3f exhibited inhibitory 3.80 µM ∼26 higher acarbose. The kinetic studies mechanism compounds reversible mixed types towards α-amylase, respectively. Molecular docking...
(±)-Salvicatone A (
Silibinin and capsaicin both are natural product molecules with diverse biological activities. In this article, we investigated the anti-inflammatory effects of silibinin combined in lipopolysaccharide (LPS)-induced RAW264.7 cells. The results showed that strongly inhibited LPS-induced nitric oxide (NO), tumor necrosis factor-α (TNF-α), Interleukin-6 (IL-6), COX-2. Moreover, potently nuclear factor-κB (NF-κB) mitogen-activated protein kinase (MAPK) signaling pathways. present study indicate...
To characterize the aroma components of Sachima and provide insight into influence egg on flavor Sachima, key aroma-active compounds in four commercial Sachimas with different content, which named Premium, Classical, Whole egg, Egg yolk, were identified using GC-MS-O analysis, extract dilution analysis (AEDA) combined sensory evaluation. In total, 75 volatile by GC-MS, including 26 revealed having activities AEDA/GC-O. The major aldehydes heterocyclic compounds. OAV further significant...
Dihydroartemisinin (DHA) has recently attracted increasing attention for its low toxicity and high antitumor activity. DHA been reported to have synergistic anticancer effects with a variety of drugs in the clinic; however, molecular mechanism by which inhibits tumorigenesis improves oxaliplatin cytotoxicity colon cancer cells is still not well understood. In this study, we found that can inhibit cell proliferation colony formation dose-dependent manner. Prohibitin 2 (PHB2) potential target...
Yeast extract (YE) is rich in amino acids, nucleotides, peptides, and other flavor substances, a natural nutrient, umami, enhancer. However, certain YE samples impart yeasty that affects the quality parameters of YE. We compared solid-phase microextraction (SPME), solvent-assisted evaporation (SAFE), dynamic headspace sample preparation (DHS), stir bar sorptive extraction (SBSE), pretreatment methods for volatiles substances SPME was selected as suitable method, aroma dilution analysis...
Chromatographic fractionation of Sigesbeckia glabrescens led to the identification 10 new sesquiterpene lactones, named siegesbeckialides I–O (1–7) and glabrescones A–C (8–10), along with 14 known analogues. An anti-inflammatory activity assay showed that siegesbeckialide I (1) most potently inhibited LPS-induced NO production in RAW264.7 murine macrophages. Furthermore, suppressed protein expression iNOS COX2, as well release PGE2, IL-1β, IL-6, TNF-α LPS-stimulated cells. Mechanistically,...
PADI4 has extensive expression in many tumors. This study applied as a tumor marker to stimulate DC- (dendritic cell-) CIK (cytokine-induced killer), an immunotherapy approach. A plasmid was transfected into EC-originating ECA-109 cells. gene also inserted prokaryotic vector produce recombinant protein. Lysate from PADI4-overexpressing cells or the purified protein used load DCs, and were then coincubated with DC cell phenotypes determined using flow cytometry. The proliferation viability of...
Background Patients with acute toxic hemoperfusion are prone to deep vein thrombosis. However, there is no risk assessment model for thrombosis in patients hemoperfusion. Therefore, we compared three commonly used models determine the most suitable of Methods Caprini, Autar, and Padua were assess poisoning admitted a grade A hospital Shandong province from October 2017 February 2019. The predictive values using receiver operating characteristic (ROC) curve analysis. Results scores 7.55 ±...
ABSTRACT Background: Hashimoto’s thyroiditis (HT) is an independent risk factor for papillary thyroid carcinoma (PTC), but the underlying mechanism remains unknown. The incidence of PTC in patients with HT significantly elevated, and presence both contributes to a higher rate misdiagnosis. Materials Methods: Gene ontology (GO) enrichment analysis Kyoto Encyclopedia Genes Genomes (KEGG) pathway were performed on nodule gene chip dataset from GEO Datasets. Serum clinical data 191 nodules at...
Secondary organizing pneumonia (SOP) is a nonspecific inflammatory response towards acute lung injuries caused by various diseases. However, (OP) secondary to occupational nitrogen oxide poisoning has been reported rarely. We report 49-year-old man who suffered from after inhaling mixed gas at work. After pathological examination, he was diagnosed with OP. In the absence of other underlying factors causing OP, SOP owing poisoning. systematic treatment, patient recovered and discharged in...
Abstract Programmed cell death 5 (PDCD5) has been reported to be expressed at low levels in various types of cancers and can upregulated rapidly migrate from the cytoplasm nucleus when is induced. It believed an important prognostic marker for response cancer therapy. Further study molecular mechanism by which PDCD5 exerts its antitumour activity exploration toxicity high-efficiency drugs targeting may reveal a promising strategy clinical In this study, function colon tumorigenesis were...
The increasing incidence of gastrointestinal stromal tumors (GISTs) has led to the discovery more novel prognostic markers. We aim establish an unsupervised model for early prediction prognosis future patients with GISTs and guide clinical treatment.We downloaded dataset through cBioPortal website. extracted information pathological information, including microsatellite instability (MSI) score, fraction genome altered (FGA) tumor mutational burden (TMB), copy number alteration (CNAB), GISTs....