A5101777349- Hippo pathway signaling and YAP/TAZ
- Folate and B Vitamins Research
- Sarcoma Diagnosis and Treatment
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- Immune cells in cancer
- Gene expression and cancer classification
- RNA Research and Splicing
- Drug Transport and Resistance Mechanisms
- Virus-based gene therapy research
- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Molecular Biology Techniques and Applications
- MicroRNA in disease regulation
- Genomics and Chromatin Dynamics
- Cell death mechanisms and regulation
- Single-cell and spatial transcriptomics
- Cell Adhesion Molecules Research
- Dermatology and Skin Diseases
- Bioactive Compounds and Antitumor Agents
- Nitrogen and Sulfur Effects on Brassica
- Ferroptosis and cancer prognosis
- Fibroblast Growth Factor Research
- Cancer therapeutics and mechanisms
- Genomics, phytochemicals, and oxidative stress
University of Pennsylvania
2017-2025
University of Utah
2007-2023
Cancer Research Institute
2019-2023
Howard Hughes Medical Institute
2023
Penn Center for AIDS Research
2022
Cancer Research Institute of the Slovak Academy of Sciences
2022
California University of Pennsylvania
2018-2020
North Dakota State University
2016
Dakota State University
2016
Wells Fargo (United States)
2016
Sweat out the fat with TSLP! Thymic stromal lymphopoietin (TSLP) is a cytokine that can promote immune responses characterize allergic diseases. Choa et al . found mice engineered to produce elevated TSLP displayed selective white adipose tissue loss protected them from obesity, insulin resistance, and steatohepatitis (see Perspective by Schneider). Protection was not mediated eosinophils, regulatory T cells, or innate lymphoid cells. Rather, TLSP induced migration of conventional cells...
Abstract The initiation and progression of cancer are intricately linked to the tumor microenvironment (TME). Understanding function specific cancer-TME interactions poses a major challenge due in part complexity vivo microenvironment. Here we predict from single cell transcriptomic maps both human colorectal cancers (CRCs) mouse CRC models, ask how these altered organoid (tumoroid) cultures, functionally recapitulate myeloid-carcinoma vitro. Tumoroid cultures suppress gene expression...
Abstract Resistance to radiotherapy is a major obstacle for effective cancer treatment. Both cancer-associated fibroblasts (CAF) within the tumor microenvironment (TME) and Notch signaling are implicated in radioresistance, but their potential interrelationship unclear. Here, we report that irradiated samples obtained from luminal breast patient tumors express higher levels of ligand Dll1 have greater number αSMA- FAP-expressing activated CAFs. Single cell transcriptomic profiles further...
Lipid nanoparticles (LNPs) have emerged as pivotal vehicles for messenger RNA (mRNA) delivery to hepatocytes upon systemic administration and antigen-presenting cells following intramuscular injection. However, achieving mRNA non-hepatocytes remains challenging without the incorporation of targeting ligands such antibodies, peptides, or small molecules. Inspired by comb-like polymeric architecture, here we utilized a multiarm-assisted design construct library 270 dendron-like degradable...
Direct plating of synovial fluid (SF) on agar-based media often fails to identify pathogens in septic arthritis (SA). We developed a PCR assay for the simultaneous detection Kingella kingae and Staphylococcus aureus from SF evaluate molecular estimate incidence K. SA North America. The was based cpn60 gene spa S. multiplex real-time PCR. identified 50% patients between 0 5 yr age (n=6) but not any >18 old (n=105). failed detect all samples. inferior culture-based method aureus, detecting...
Synovial sarcoma (SS) is an aggressive soft-tissue that often discovered during adolescence and young adulthood. Despite the name, synovial does not typically arise from a synoviocyte but instead arises in close proximity to bones. Previous work demonstrated mice expressing characteristic SS18-SSX fusion oncogene myogenic factor 5–expressing (Myf5-expressing) cells develop fully penetrant sarcomagenesis, suggesting skeletal muscle progenitor cell origin. However, Myf5 restricted committed...
We have synthesized a fluorescent polymer which self-assembles into polymersomes and targets the encapsulated anticancer drug to cancer cell mitochondria.
Abstract Within the past 30 years, obesity and associated disorders such as Type II diabetes are rapidly becoming world-wide epidemics. diabetes, caused by loss of insulin sensitivity, accounts for $327 billion annually in U.S. Recent studies have shown that immune system plays a critical role regulating metabolic function adipose tissue. Importantly, is disease chronic low-grade inflammation, T regulatory cells (Tregs) can help maintain sensitivity suppressing inflammation monocytes, CD8 T,...
<div>Abstract<p>Globally, hepatocellular carcinoma (HCC) is one of the most commonly diagnosed cancers and a leading cause cancer-related death. We previously identified an immune evasion pathway whereby tumor cells produce retinoic acid (RA) to promote differentiation intratumoral monocytes into protumor macrophages. Retinaldehyde dehydrogenase 1 (RALDH1), RALDH2, RALDH3 are three isozymes that catalyze RA biosynthesis. In this study, we have RALDH1 as key driver production in...
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