A5023912898- Wnt/β-catenin signaling in development and cancer
- Liver Disease Diagnosis and Treatment
- Birth, Development, and Health
- Cancer-related gene regulation
- Liver physiology and pathology
- Higher Education Research Studies
- Photosynthetic Processes and Mechanisms
- Diet, Metabolism, and Disease
- Computational Drug Discovery Methods
- Evaluation of Teaching Practices
- Genomics and Phylogenetic Studies
- Race, History, and American Society
- Adipose Tissue and Metabolism
- Pancreatitis Pathology and Treatment
- Fibroblast Growth Factor Research
- Plant biochemistry and biosynthesis
- Protist diversity and phylogeny
- Microbial Community Ecology and Physiology
- Drug Transport and Resistance Mechanisms
- Management and Marketing Education
- RNA and protein synthesis mechanisms
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- RNA Research and Splicing
- Inorganic and Organometallic Chemistry
FibroGen (United States)
2025
Centre for Genomic Regulation
2024
Washington University in St. Louis
2017-2023
Illinois Wesleyan University
2010-2023
Florida Agricultural and Mechanical University
2000-2021
University of Tennessee at Chattanooga
2019-2021
Pew Charitable Trusts
2019
Mayo Clinic in Arizona
1999-2018
Nationwide Children's Hospital
2013-2017
The Ohio State University
2015-2016
β-Catenin, the central component of canonical Wnt pathway, plays important roles in processes liver regeneration, growth, and cancer. Previously, we identified temporal expression β-catenin during development. Here, characterize hepatic phenotype, resulting from successful deletion developing hepatoblasts utilizing Foxa3-cyclization recombination floxed - (exons 2 through 6) transgenic mice. β-Catenin loss livers resulted significantly underdeveloped after embryonic day 12 (E12) with...
Adult hepatic stem cells or oval are facultative in the liver that activated during regeneration only inhibition of innate hepatocyte proliferation. On basis its involvement cancer, regeneration, and development, we investigated role Wnt/β-catenin pathway cell response, which was initiated male Fisher rats with 2-acetylaminofluorine two-third partial hepatectomy (PHX). Extensive activation proliferation were observed at 5 10 days post-PHX, as indicated by hematoxylin-eosin proliferating...
The Wnt/β-catenin pathway is implicated in the pathogenesis of hepatocellular cancer (HCC). We developed a transgenic mouse (TG) FVB strain that overexpresses Ser45-mutated-β-catenin hepatocytes to study effects on liver regeneration and cancer. In two independent TG lines adult mice show elevated β-catenin at hepatocyte membrane with no increase Wnt targets cyclin-D1 or glutamine synthetase. However, upon culture exhibit 2-fold thymidine incorporation day 5 (D5) when compared from wildtype...
Hepatic repair is directed chiefly by the proliferation of resident mature epithelial cells. Furthermore, if predominant injury to cholangiocytes, hepatocytes can transdifferentiate cholangiocytes assist in and vice versa, as shown various fate‐tracing studies. However, molecular bases reprogramming remain elusive. Using two models biliary where occurs through cholangiocyte hepatocyte transdifferentiation we identify an important role Wnt signaling. First up‐regulation specific proteins...
1. Experimental radiographic investigations are described in which segmentation of the barium suspension small intestine (so-called “deficiency pattern”) was induced normal human subjects. 2. The pattern by administration hypertonic solution sodium bicarbonate, glucose or chloride, addition hydrolysed fat, sprue fæcal fats, certain short chain fatty acids to suspension. 3. sulphate not flocculated solution, lactic acetic acid. Long caused flocculation an acid medium, but floccules tended be...
The Wnt/β-catenin pathway plays an important role in embryonic liver development, morphogenesis, and organogenesis. Here, we report on the activation of β-catenin during early postnatal growth. Modulation expression was studied CD-1 mice livers over a time course 0 to 30 days (PD) 3 mo. Increases total active were observed developing from PD 5 20. A concomitant increase β-catenin-transcription factor (TCF) complex along with nuclear cytoplasmic also evident, which coincided ongoing...
To correlate cloned nuclear DNA sequences with previously characterized mutations in Chlamydomonas and, to gain insight into the organization of its genome, we have begun map molecular markers using restriction fragment length polymorphisms (RFLPs). A reinhardtii strain (CC-29) containing phenotypic on nine 19 linkage groups was crossed interfertile species smithii. from each member 22 randomly selected tetrads analyzed for segregation RFLPs associated genes detected by hybridization...
Cholestatic liver diseases result from impaired bile flow and are characterized by inflammation, atypical ductular proliferation, fibrosis. The Wnt/β‐catenin pathway plays a role in duct development, yet its cholestatic injury remains indeterminate. Liver‐specific β‐catenin knockout mice wild‐type littermates were subjected to through ligation or short‐term exposure 3,5‐diethoxycarbonyl‐1,4‐dihydrocollidine diet. Intriguingly, exhibit dramatic protection injury, fibrosis, which coincides...
The aim of the study was to determine effect major complications after colorectal cancer surgery on survival and time recurrence.Patients having a curative resection follow-up at least 3 years were identified from prospective database. Major defined as Clavien-Dindo Grades 3b or 4 their impact recurrence mortality analysed by univariate multivariable analysis. Postoperative death within 30 days during initial hospitalization (Clavien-Dindo Grade 5) priori excluded.From 2003 2012, 868...
Maternal obesity is correlated with cardiovascular disease in offspring, a 1.3-fold increase events observed offspring of obese women. We have that obesity-exposed oocytes demonstrate impaired mitophagy and transmit damaged mitochondria to the offspring. Accordingly, we hypothesized maternal induces cardiac mitochondrial dysfunction via transgenerational inheritance abnormal oocyte mitochondria. mated female mice fed high-fat/high-sucrose (HFS) diet (or chow) chow-fed males assessed...
Hematopoietic stem cell (HSC) mobilization is often difficult to achieve in patients suffering from multiple myeloma and non-Hodgkin's lymphoma. Granulocyte-colony stimulating factor (G-CSF) therapy alone has not led the desired outcomes. Herein, we describe discovery of 7-cyclohexyl-4-hydroxy-8-oxo-N-(pyridazin-4-ylmethyl)-7,8-dihydro-2,7-naphthyridine-3-carboxamide 13, a hypoxia-inducible prolyl hydroxylase (HIF-PH) inhibitor, which was discovered by focusing on drug-like properties....
The central purpose of this study was to examine the connection between informal student-faculty interaction, perceived quality effort asserted in science courses, and educational gains mathematics-based courses for community college students within context Pace's (1979) concept social academic involvement. "quality effort" involvement assumes that effects on students' differential patterns growth development can be assessed through efforts expend utilizing resources provided by higher...
Student Leadership Process Development:An Assessment of Contributing College Resources Michael D. Thompson (bio) development is a prominent theme and objective in higher education (Smart, Ethington, Riggs, & Thompson, 2002), especially for residential liberal arts institutions, which tend to emphasize market the benefits dual living-and-learning environments that facilitate cultivation leadership-related attributes. Evidence such may be observed mission statements numerous well-respected...
OBJECTIVE The objective of this study was to examine the relationship between hospital surgical volume and long-term survival in patients with a new diagnosis colorectal cancer who underwent resection during fiscal years 1991–2000 Veterans Affairs (VA) health-care system. METHODS This research cohort admitted all VA hospitals October 1990 September 2000 followed through 2001. Overall 5-yr cumulative calculated from Kaplan-Meier estimates, while adjusted risk death estimated using Cox...
The results of complete thyroid function testing were normal in four desipramine nonresponders who converted to responders by addition L-triiodothyronine (T3). These findings suggest that the effectiveness T3 is not due correction subtle deficiencies.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, biological profile, and quantitative structure-activity relationship of a series novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitorsS. Y. Sit, R. A. Parker, I. Motoc, W. Han, N. Balasubramanian, J. D. Catt, P. Brown, E. Harte, M. Thompson, WrightCite this: Med. Chem. 1990, 33, 11, 2982–2999Publication Date (Print):November 1, 1990Publication History Published online1 May 2002Published inissue 1 November...
As childhood obesity increases, it is becoming important to understand the complications of in children and develop novel biomarkers. Evidence indicates that microRNAs (miRNA) are dys-regulated may serve as sensitive specific circulating Non-alcoholic fatty liver disease (NAFLD) a complication ultimately requires biopsy determine severity. While studies have been conducted adults, no study date has examined miRNAs with NAFLD. The goal this was evaluate panel selected obese compared healthy...