A5068733927- Systemic Lupus Erythematosus Research
- Mosquito-borne diseases and control
- Inflammatory Bowel Disease
- Viral-associated cancers and disorders
- Renal Diseases and Glomerulopathies
- Virology and Viral Diseases
- Biomarkers in Disease Mechanisms
- Cytomegalovirus and herpesvirus research
- Autoimmune and Inflammatory Disorders Research
- T-cell and Retrovirus Studies
- Angiogenesis and VEGF in Cancer
- Climate Change and Health Impacts
- Viral Infections and Vectors
- MicroRNA in disease regulation
- Pancreatitis Pathology and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Circular RNAs in diseases
- Atherosclerosis and Cardiovascular Diseases
- Inflammasome and immune disorders
- Treatment of Major Depression
- COVID-19 and healthcare impacts
- Nuclear Receptors and Signaling
- Pregnancy and Medication Impact
- Ocular Oncology and Treatments
- Immunotherapy and Immune Responses
Universidad Simón Bolívar
2018-2024
University of the Coast
2019-2024
Azienda Ospedaliera San Gerardo
1998-2001
University of Milano-Bicocca
2000
Post-chikungunya viral arthritis may persist for months to years after infection and is characterized by relapsing remitting symptoms. This study investigates the relationship between autoantibodies chikungunya severity, providing insights into pathogenesis. We assessed measures in a cohort of serologically confirmed cases from Colombia 2019 2021 (n = 144). measured disease flare intensity, pain, disability, then plasma antibody levels rheumatoid factor IgM, anti-cyclic citrullinated peptide...
Systemic lupus erythematosus (SLE) is a multifactorial disease characterized by the convergence of genetic, immunological, and viral elements resulting in complex interaction both internal external factors. The role Epstein-Barr virus (EBV) human endogenous retroviruses (HERV-E) as triggers maintenance pathogenesis SLE has been widely recognized. Previous studies have independently evaluated effects EBV HERV-E this disease. In work, for first time, these factors are jointly investigated...
This article describes the main differences between COVID-19-induced acute kidney injury (AKI-COVID19) in patients with previous normal renal function (AKI-NRF) and those chronic disease (AKI-CKD) treated a high complexity clinic Barranquilla (Colombia).The included this study (n: 572) were positive diagnosis of COVID-19 confirmed by detection PCR for SARS-CoV-2. Of these patients, 188 developed AKI during their hospital stay. Patients' epidemiological data, serum parameters, clinical...
Zika virus infection has been associated with the development of a spectrum neurologic disease including Guillain–Barre syndrome (GBS)1. GBS is an autoimmune disorder peripheral nervous s...
The aim of this study was to identity in silico the relationships among microRNAs (miRNAs) and genes encoding transcription factors, ubiquitylation, DNA methylation, histone modifications systemic lupus erythematosus (SLE). To identify miRNA dysregulation SLE, we used miR2Disease PhenomiR for information about miRNAs exhibiting differential regulation disease other biological processes, HMDD experimentally supported human miRNA–disease association data from genetics, epigenetics, circulating...
Objective To define the relationship between chronic chikungunya post-viral arthritis disease severity, cytokine response and T cell subsets in order to identify potential targets for therapy. Methods Participants with were recruited from Colombia 2019–2021. Arthritis severity was quantified using Disease Activity Score-28 an Arthritis-Flare Questionnaire adapted arthritis. Plasma concentrations (interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, interferon-γ tumor necrosis...
Background As with many other chronic diseases, systemic lupus erythematosus (SLE) and nephritis (LN) have significant impacts on the health-related quality of life (HRQoL). Medication non-adherence is a challenge in management SLE, consistently up to 75% patients being non-adherent their SLE medications. There need assess patient’s perspective using patient-reported outcomes (PROs) better understand current impact LN HRQoL treatment adherence our region. The aim this study was explore...
Recent studies have shown that the hematopoietic system is under neuroendocrine control. In particular, thrombopoiesis has been proven to be stimulated by melatonin, and pineal indole effective in treatment of thrombocytopenia resulting from different causes. At present, however, there are no data concerning possible thrombopoietic activity indoles other than melatonin. The present study was carried out evaluate effect a concomitant administration 5‐methoxytryptamine patients with...
Angiogenesis and immunosuppression are the main biological mechanisms responsible for cancer progression. Moreover, recent observations suggesting a negative influence of angiogenesis on anticancer immunity have shown that some angiogenic factors, such as VEGF, may induce immunosuppression. In addition, evidence abnormally high blood levels VEGF has been proven to be associated with resistance IL-2 immunotherapy. The present study was performed establish possible relation ship between...
Several endogenous hormones have been proven to stimulate cancer growth, whereas at present very few are known display oncostatic activity. The most widely investigated antitumor hormone is the pineal indole melatonin (MLT), and progression has shown be associated with a decline in MLT secretion. Recently, another hormone, adrenal steroid dehydroepiandrosterone-sulfate (DHEAS), appeared exert effects similar those previously described for MLT. In addition, experimental studies suggest...
Introduction: Systemic lupus erythematosus (SLE) is a multifactorial disease characterized by the convergence of genetic, immunological, and viral elements resulting in complex interaction both internal external factors. Research has recognized role that play Epstein-Barr virus (EBV) Human endogenous retrovirus (HERV-E) as triggers maintenance disease. A fundamental study area stands out dynamics between these agents their physiopathology to unveil influence SLE development...
Background: Chikungunya virus (CHIKV) is an alphavirus spread by mosquitos that causes arthralgias and arthritis may last for years. The objective of this study was to describe the progression T cell immunology over a two-year period. Methods: A cohort 40 cases serologically confirmed CHIKV from Magdalena Atlántico, Colombia were followed in 2019 again 2021. Arthritis disease severity, disability, pain, stiffness, physical function, mobility, fatigue, anxiety, sleep disturbances depression...
<title>Abstract</title> Systemic lupus erythematosus (SLE) is a multifactorial disease characterized by the convergence of genetic, immunological, and viral elements resulting in complex interaction both internal external factors. Research has recognized role that play Epstein-Barr virus (EBV) Human endogenous retrovirus (HERV-E) as triggers maintenance disease. A fundamental study area stands out dynamics between these agents their physiopathology to unveil influence SLE development...
<h3>Background</h3> Obstetric morbidity (OM) is higher in SLE women than healthy ones. Few data on pregnancy outcomes Latin America (LA) have been reported. <h3>Objectives</h3> To study LA. <h3>Methods</h3> GLADEL 2.0 an observational prevalent/incident cohort started 2019. date, 43 centers from 10 LA countries enrolled 1030 patients (1982/1997 ACR or SLICC criteria). Women with ≥1 were included. Past and ongoing (6, 12, 24 months follow-up) OM (miscarriages, fetal deaths, preeclampsia,...
The Chinese community is one of the main minorities in Colombia, and although China has made advances public health, it faces a growing burden cardiovascular diseases. This study focuses on evaluating risk factors immigrants Barranquilla, due to lack specific data this population. Methods: A cross-sectional was conducted with 67 over 18 years age residing Barranquilla. Sociodemographic, anthropometric, clinical, biochemical were collected through structured interviews medical record reviews....
Objective: Chikungunya virus is spread by mosquitos and causes a debilitating chronic arthritis that has no standard treatment to date specific measures of disease activity. The objective this expert group was develop measure chikungunya would be useful for clinical trials patient care. Methods: A rheumatologists biostatisticians experienced in the pathological mechanisms evaluated component inclusion activity score (CHIK-DAS). Utilizing data from Colombian cohort 158 patients, linear...
Introduction: Mesoamerican nephropathy is a tubule-interstitial whose etiology still unknown. However, clinical cases like have been described in other geographically distant and ethnically diverse regions. Still, they all common factor: the intensity of heat rural physical labor. Objective: To study whether this entity could occur among workers non-Mesoamerican region with similar climatic working conditions, Colombian Caribbean countryside, to consider how much repetitive dehydration weigh...
Crohn's disease (CD) results from an aberrant immune response against commensal microbiota in genetically susceptible hosts. However, the nature of defects, microflora involved, and genetic susceptibility remain incompletely defined controversial. This review seeks to describe present state association between CD renal disease; moreover, we highlight convergence with amyloidosis that can trigger sustained inflammation, producing pathological alteration observed both diseases. The following...
Crohn's disease (CD) results from an aberrant immune response against the commensal microbiota in genetically susceptible hosts. However, nature of defects, microflora involved and genetic susceptibility remain incompletely defined controversial. Extraintestinal manifestations occur up to 25-35% patients generally precede onset gastrointestinal symptoms, which are often a colonic influenced by activity. Renal can be considered dependent on same mechanism that determines inflammatory bowel...
Se designa con el nombre de amiloidosis a un grupo enfermedades poco frecuentes, que se caracterizan por depósito extracelular material proteico fibrilar denominado amiloide. La afectación renal en la sistémica es frecuente, lo le asocia pronóstico desfavorable, al ser falla segunda causa muerte los pacientes presentan. El objetivo este trabajo consistió presentar caso hombre 55 años, hipertenso novo, cuadro clinico 7 meses evolución edema progresivo asociado disnea, oliguria y hematuria,...