A5028674863- Diabetes Treatment and Management
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Pancreatic function and diabetes
- Vagus Nerve Stimulation Research
- Cardiac Fibrosis and Remodeling
- Blood Pressure and Hypertension Studies
- Renin-Angiotensin System Studies
- Cardiac Health and Mental Health
- Receptor Mechanisms and Signaling
- Telomeres, Telomerase, and Senescence
- Metabolism, Diabetes, and Cancer
- Neuropeptides and Animal Physiology
- RNA regulation and disease
- Nicotinic Acetylcholine Receptors Study
- Apelin-related biomedical research
- Stress Responses and Cortisol
- Cardiovascular Disease and Adiposity
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2021-2025
Universidade de São Paulo
2020-2024
Instituto do Coração
2021-2023
Background/Objectives: Aging is associated with structural and functional changes in the heart, including hypertrophy, fibrosis, impaired contractility. Cellular mechanisms such as senescence, telomere shortening, DNA damage contribute to these processes. Nuclear factor kappa B (NF-κB) has been implicated mediating cellular responses aging tissues, increased NF-κB expression observed hearts of rodents. Therefore, suspected play an important regulatory role molecular processes occurring heart...
Abstract The mechanisms regulating immune cells recruitment into the heart during healing after an acute myocardial infarction (AMI) have major clinical implications. We investigated whether cholinergic stimulation with pyridostigmine, a cholinesterase inhibitor, modulates and spleen responses cardiac remodeling AMI in spontaneous hypertensive rats (SHRs). Male adult SHRs underwent sham surgery or ligation of left coronary artery were randomly allocated to remain untreated pyridostigmine...
Abstract Cardiovascular risk increases during the aging process in women with atherosclerosis and exercise training is a strategy for management of cardiac risks at-risk populations. Therefore, aims this study were to evaluate: (1) influence on function, hemodynamics, cardiovascular autonomic modulation, baroreflex sensitivity females at onset reproductive senescence; (2) impact age-related dysfunctions model. Eighteen Apolipoprotein-E knockout female mice divided equally into young (Y),...
ABSTRACT The renin-angiotensin system (RAS) comprises a biochemical cascade that hydrolyzes angiotensinogen into several different bioactive peptides, which can activate receptors promoting plenty of specific effects. aim this study was to evaluate the presence putative product alamandine, pentapeptide alamandine-(1-5) in circulation and its biological activity. To accomplish we have used mass spectrometry (MALDI/TOF/TOF, LC-MS/MS) methodologies including isolated blood vessels, perfused...
Cardiovascular diseases, particularly Acute Myocardial Infarction (AMI), are the leading cause of death worldwide. Studies show that empagliflozin improves cardiac function and outcomes in patients with heart failure. This study hypothesizes different doses (3 mg/kg 10 mg/kg) affect collagen deposition differently. Male Wistar rats were divided into four groups: control (Ctrl), infarcted treated 3 (AMI+EMPA3), (AMI+EMPA10). Infarcted groups underwent left coronary artery occlusion. Treated...
Introduction: Several experimental studies have shown improvement in cardiac function of infarcted animals (diabetic or not) when treated with empagliflozin. Likewise, several clinical improved outcomes patients heart failure reduced ejection fraction preserved using Methods: Wistar rats were divided into 2 groups: AMI - acute myocardial infarction (n=8) and EMPA + Empagliflozin (n=9).The both groups anesthetized submitted to thoracotomy ligature the left coronary artery. The group received...
Abstract Atherosclerosis is a chronic inflammatory disease characterized by the formation of atheroma plaque in arterial wall, process that causes long-term obstruction arteries. Postmenopausal women tend to have greater body adiposity, factor corroborate increased risk cardiovascular events and development atherosclerosis. Therefore, aim this study was evaluate association experimental model atherosclerosis with ovarian deprivation consumption high-fat diet metabolic, hemodynamic, autonomic...