A5085779596- Renin-Angiotensin System Studies
- Cardiac Fibrosis and Remodeling
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Tissue Engineering and Regenerative Medicine
- Neurotransmitter Receptor Influence on Behavior
- Sodium Intake and Health
- Renal function and acid-base balance
- Ion channel regulation and function
- Neuropeptides and Animal Physiology
- Helicobacter pylori-related gastroenterology studies
- Nitric Oxide and Endothelin Effects
- Circadian rhythm and melatonin
- Gastroesophageal reflux and treatments
- Cardiac Ischemia and Reperfusion
- Gastric Cancer Management and Outcomes
- Receptor Mechanisms and Signaling
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Hormonal Regulation and Hypertension
- Neuroscience and Neuropharmacology Research
- Heart Failure Treatment and Management
- Neuroscience and Neural Engineering
- Blood Pressure and Hypertension Studies
- Birth, Development, and Health
Universidade Federal de Minas Gerais
2008-2025
Young women exhibit lower rates of cardiovascular disease (CVD) than age-matched men, a protective effect often attributed to estrogen's influence on cardiac and mitochondrial function. The risk CVD increases in post-menopausal women, likely due estrogen deficiency aldosterone's negative effects, including those mitochondria other cellular targets. This study aimed explore the link between dysfunction health. We hypothesized that estrogen-deprived conditions, aldosterone could stimulate...
Parkinson's disease (PD) is a neurological disorder requiring early and accurate diagnosis for effective management. Machine learning (ML) has emerged as powerful tool to enhance PD classification diagnostic accuracy, particularly by leveraging wearable sensor data. This survey comprehensively reviews current ML methodologies used in classifying Parkinsonian tremors, evaluating various tremor data acquisition methodologies, signal preprocessing techniques, feature selection methods across...
Alamandine is the newest identified peptide of renin-angiotensin system (RAS) and has protective effects in cardiovascular system. Although involvement classical RAS components genesis progression cardiac remodeling well known, less known about alamandine. Therefore, present study we investigated alamandine on induced by transverse aortic constriction (TAC) mice. Male mice (C57BL/6), 10-12 wk age, were divided into three groups: sham operated, TAC, TAC + ALA (30 µg/kg/day for 14 days). The...
Failure of Helicobacter pylori treatment is a growing problem in daily practice.To evaluate the efficacy two new regimes as second-line options randomized and prospective study.Patients whom first eradication regime containing clarithromycin had failed were included. After performing gastroscopy 13C-urea breath test (UBT), patients to receive combination 20 mg rabeprazole, 500 levofloxacin, 200 (two tablets) furazolidone administered once for 10 days (RLF) or 120 bismuth subcitrate, 100...
Maturation involves a series of morphofunctional alterations vital to heart development. Its regulatory mechanisms are only now being unveiled. Evidence implies that adrenergic signaling regulates cardiac maturation, but the poorly understood. To address this point, we blocked β-ARs or performed sympathectomy followed by rescue experiments with isoproterenol in neonatal mice. Our study identifies β-AR stimuli as maturation signal for cardiomyocytes and highlights importance pathway...
New Findings What is the central question of this study? How does swimming exercise training impact hydro‐electrolytic balance, renal function, sympathetic contribution to resting blood pressure and cerebrospinal fluid (CSF) [Na + ] in rats fed a high‐sodium diet from weaning? main finding its importance? An exercise‐dependent reduction was associated with decreased CSF ], sympathetically driven vasomotor tonus fibrosis indicating that anti‐hypertensive effects might involve neurogenic...
ABSTRACT The renin-angiotensin system (RAS) plays a critical role in the regulation of cardiovascular system. Mas-related G protein receptor member D (MrgD) is alamandine, and both are components RAS noncanonical arm. Alamandine/MrgD induces vasodilation, anti-inflammatory, anti-fibrotic anti-oxidative effects. In contrast, Mrgd gene deletion leads to remarkable dilated cardiomyopathy (DCM) mice. Here, we aimed investigate molecular mechanisms DCM triggered by MrgD left ventricle isolated...
ABSTRACT The renin-angiotensin system (RAS) comprises a biochemical cascade that hydrolyzes angiotensinogen into several different bioactive peptides, which can activate receptors promoting plenty of specific effects. aim this study was to evaluate the presence putative product alamandine, pentapeptide alamandine-(1-5) in circulation and its biological activity. To accomplish we have used mass spectrometry (MALDI/TOF/TOF, LC-MS/MS) methodologies including isolated blood vessels, perfused...
The renin-angiotensin system (RAS) is composed of a series peptides, receptors, and enzymes that play pivotal role in maintaining cardiovascular homeostasis. Among the most important players this are angiotensin-II angiotensin-(1-7) peptides. Our group has recently demonstrated alamandine (ALA), peptide with structural functional similarities to angiotensin-(1-7), interacts cardiomyocytes, enhancing contractility via Mas-related G protein-coupled receptor member D (MrgD). It currently...