A5039491086- Diabetes Treatment and Management
- Liver Disease Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Viral-associated cancers and disorders
- Urinary Bladder and Prostate Research
- Gastrointestinal disorders and treatments
- Dialysis and Renal Disease Management
- Cytomegalovirus and herpesvirus research
- Diverticular Disease and Complications
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Family Support in Illness
- Lipoproteins and Cardiovascular Health
- Diabetes Management and Research
- Multiple and Secondary Primary Cancers
- Urinary Tract Infections Management
- Liver Disease and Transplantation
- Metabolism, Diabetes, and Cancer
- Retinal Diseases and Treatments
- Bladder and Urothelial Cancer Treatments
- Intestinal Malrotation and Obstruction Disorders
- Leptospirosis research and findings
- Acute Ischemic Stroke Management
- Bioactive Natural Diterpenoids Research
- Obstructive Sleep Apnea Research
China Medical University
2020-2024
China Medical University Hospital
2020-2024
National Yang Ming Chiao Tung University
2023
China Medical University
2020-2021
Weatherford College
2021
We aimed to compare cardiovascular risks among participants with T2DM and without subsequent HTN T2DM.From January 1, 2000, December 31, 2018, we identified 16,236 matched pairs of (T2DM cohorts), 53,509 (HTN 21,158 comorbid history or (comorbid cohorts) from Taiwan's National Health Insurance Research Database. Cox proportional-hazard models were used calculate the risk disease.The mean follow-up time this study was 6.75 years. Mean incident rates coronary artery disease for cohorts,...
Abstract Background To determine the bidirectional link between periodontitis and fibromyalgia. Methods In this cohort study, 196,428 patients propensity score‐matched non‐periodontitis controls were enrolled. A Cox proportional hazard model was utilized to estimate risk of fibromyalgia survival analysis adopted assess time‐dependent effect on Subgroup analyses stratified by age, sex, tracking period conducted identify susceptible populations. parallel symmetrical that recruited 141,439...
Objective This study aimed to investigate the risk of Alzheimer’s disease among patients with age-related macular degeneration and its association confounding comorbidities. Method was a population-based, retrospective cohort study. By accessing data from National Health Insurance Research Database Taiwan, we identified 10,578 aged 50–100 years who were newly diagnosed between 2000 2012 non- individuals. The comorbidities assessed osteoporosis, diabetes, cirrhosis, cerebrovascular disease,...
Background: Previous findings on using Glucagon-like peptide-1 receptor agonist (GLP1-RA) as an antidepressant were conflicting, lacking large-scale studies. We used population-based data to investigate depression and anxiety risk in diabetic patients receiving the medication. Methods: From claims records of National Health Insurance Research Database (NHIRD) Taiwan, we identified cohorts 10,690 GLP1-RA users 42,766 propensity score-matched without use from with diabetes mellitus (DM)...
Objective: A number of publications have assessed the prevalence hypertension in polycystic ovary syndrome (PCOS) patients with inconclusive results. Since general populations occurrence is related to age and comorbidities, we investigated incidence rate hazard ratios (HRs) between healthy subjects young women PCOS as well comorbidities. Methods: We conducted a population-based retrospective cohort study by using National Health Insurance Research Database Taiwan. The included diagnosis 2000...
Abstract Background Insulin is highly recommended for diabetes management in persons with liver cirrhosis. However, few studies have evaluated its long-term effects these persons. We conducted this study to compare the risks of mortality, liver-related complications, and cardiovascular events type 2 mellitus (T2DM) compensated Methods From January 1, 2000, December 31, 2012, we selected 2047 insulin users 4094 propensity score-matched nonusers from Taiwan’s National Health Insurance Research...
This study aimed to investigate the risk of Parkinson's disease (PD) among patients with age-related macular degeneration (AMD) and its association confounding comorbidities.A population-based retrospective cohort was conducted using Longitudinal Health Insurance Database 2000 (LHID2000). We established AMD non-AMD cohorts from January 1, December 31, 2012 determine diagnosis PD. A total 20,848 were enrolled, 10,424 controls matched for age, sex, index year at a 1:1 ratio. The follow-up...
Objective: Psychological distress is considered a factor for cancer development. However, the impact of mood disorders (depression and bipolar) on development cervical remains uncertain. We conducted nationwide population-based retrospective cohort study to investigate association between subsequent risk developing cancer. Methods: A total 138,130 participants’ profiles 2000 2012 were extracted from National Health Insurance Research Database subdivided into mood-disorder (27,626...
Abstract Background This study aims to provide 14-year nationwide epidemiology data evaluate the incidence ratio of APS in Taiwan and condition comorbidities by analyzing National Health Insurance Research Database. Methods Nineteen thousand one hundred sixty-three patients newly diagnosed as having during 2000–2013 period 76,652 controls (with similar distributions age sex) were analyzed. Results The increased from 4.87 6.49 per 10,000 person-years population 2000–2013. with after 20 years...
To investigate the cancer types and risk factors of secondary primary malignancy (SPM) in patients with upper tract urothelial carcinoma (UTUC) Taiwan. Using National Health Insurance Research Dataset catastrophic illness registry, we enrolled newly diagnosed UTUC from 2000 to 2013. Those without registration were excluded study. The hazard ratios (HRs) subsequent SPMs calculated according antecedent malignancy. We analyzed for developing using multivariate Cox proportional models. A total...
Acute ST-elevation myocardial infarction (STEMI) elicits a robust cardiomyocyte death and inflammatory responses despite timely revascularization.This phase 1, open-label, single-arm, first-in-human study aimed to assess the safety efficacy of combined intracoronary (IC) intravenous (IV) transplantation umbilical cord-derived mesenchymal stem cells (UMSC01) for heart repair in STEMI patients with impaired left ventricular ejection fraction (LVEF 30-49%) following successful reperfusion by...
The association between vesicoureteral reflux (VUR) and chronic kidney disease (CKD) risk remains unestablished. We investigated the incidence of CKD in children with VUR Taiwan evaluated whether they had a higher than general population. A nationwide population-based cohort study was conducted among identified using Taiwan's National Health Insurance Research Database from 2000 to 2013. defined according International Classification Diseases, Ninth Revision, Clinical Modification codes....
This study aimed to investigate the long-term outcomes of sulfonylurea (SU) use in patients with T2DM and compensated liver cirrhosis. From January 1, 2000, December 31, 2012, we selected data 3781 propensity-score-matched SU users nonusers from Taiwan’s National Health Insurance Research Database. The mean follow-up time for this was 5.74 years. Cox proportional hazards models robust sandwich standard error estimates were used compare risks main between nonusers. incidence mortality during...
Many patients with obesity in Taiwan seek Chinese herbal medicines (CHM) from traditional medicine (TCM) clinics. This study aimed to estimate the risk of major adverse cardiovascular events (MACEs) adults diagnosed obesity, or without CHM.
Type 2 diabetes mellitus (T2DM) management in patients with cirrhosis is complicated. No clinical trials have investigated appropriate antidiabetic drug use these patients. This study compared the risks of all-cause mortality, major adverse cardiovascular events (MACE) and hepatic outcomes between T2DM using not thiazolidinedione (TZD).We selected 1,705 propensity score-matched TZD users nonusers from a Taiwan National Health Insurance Research Database cohort compensated January 1, 2000,...
Summary Background and purpose Stroke is a rare complication of snakebites, but may lead to serious sequelae. We aimed explore the relationship between venomous snakebite risk for acute stroke, in nationwide population-based cohort study. Methods This retrospective study used claims data 1 January 2000 31 December 2012, from Taiwan National Health Insurance Research Database. The included patients aged 18 years or older with (n = 535), matched propensity score controls without 2140)....
Studies assessing the efficacy of pioglitazone solely for primary stroke prevention in Asian patients with type 2 diabetes mellitus (DM) and present multiple cardiovascular (CV) risk factors are rare. Thus, we aimed to assess effect on DM without established CV diseases but diseases.Between 2000 2012, enrolled aged ≥ 18 years, who were newly diagnosed had at least one following factors: hypertension hyperlipidemia. Patients a history those using insulin or glucagon-like peptide-1 agonist...
Abstract Cervical cancer is a common malignancy in women. The presence of hydronephrosis patients with cervical can be challenging clinical problem. appropriate management these and the prediction their outcomes are concerns among gynecologists, urologists, medical oncologists, radiation nephrologists. We enrolled total 2225 over 12-year period from nationwide database Taiwan's National Health Insurance Bureau. Among them, 445 had concomitant hydronephrosis. remaining 1780 without were...
Background Whether a sex difference exists in long-term cardiovascular (CV) outcomes after acute myocardial infarction (AMI) is worth exploration. This study sought to investigate the relationships among sex, age, and prognosis AMI. Methods population-based retrospective cohort used Taiwan's National Health Insurance Research Database differences in-hospital CV patients with We enrolled who were first diagnosed AMI from January 1, 2000 December 31, 2013. The of interest included all-cause...
Purpose This study aimed to determine the risk and time trends of herpes zoster among patients with head neck cancer, or without radiotherapy. Methods A total 2160 cancer were enrolled. The radiotherapy non- cohorts frequency-matched at a 1:1 ratio according sex, age, index date. Moreover, 1080 matched non-cancer individuals considered normal controls. Data obtained from National Health Insurance Research Database Cancer Registry. primary end point was incidence zoster, adjusted confounding...
Patients with endometriosis may seek traditional Chinese medicine (TCM) to help them conceive. The present study aims evaluate the effects of TCM on reproductive and pregnancy outcomes in patients endometriosis.The taken from National Health Insurance (NHI) research database between 2000 2012 were divided into two cohorts based use treatment. matched by age comorbidities followed up until a new diagnosis infertility, ectopic pregnancy, or miscarriage. Multivariable Cox proportional hazards...
Overweight and hyperlipidemia, the two established risk factors for acute ischemic stroke, are paradoxically associated with favorable outcomes. The paradox may be resolved by concept of protein energy wasting (PEW), in which total cholesterol level body mass index used as nutritional indexes predicting outcomes chronic kidney disease.Among 12 271 people stroke disease, 2086 were defined being at PEW-with a <22 kg/m2 plus either serum albumin <38 g/L or <4.14 mmol/L (160 mg/dL) without use...
The diverse presentation of Meckel's diverticulum (MD) is a diagnostic challenge for clinicians and most previous studies consist single institutional case series. aim this study was to review the related diagnoses MD investigate epidemiological characteristics using Taiwan's National Health Insurance Research Database.We conducted an observational population-based database. Patients diagnosed with who concurrently received intestinal surgery were identified. We analyzed patients'...