A5103195353- Vascular Tumors and Angiosarcomas
- Cutaneous lymphoproliferative disorders research
- Eosinophilic Disorders and Syndromes
- HIV/AIDS Research and Interventions
- Acute Myeloid Leukemia Research
- Polyomavirus and related diseases
- Cardiac tumors and thrombi
- HIV, Drug Use, Sexual Risk
- Blood Coagulation and Thrombosis Mechanisms
- Renal Transplantation Outcomes and Treatments
- Cell Adhesion Molecules Research
- Hematopoietic Stem Cell Transplantation
- Cancer Diagnosis and Treatment
- Ocular Diseases and Behçet’s Syndrome
- Lymphoma Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Muscle and Compartmental Disorders
- IL-33, ST2, and ILC Pathways
- Dialysis and Renal Disease Management
- Parathyroid Disorders and Treatments
- Syphilis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Acute Kidney Injury Research
- Platelet Disorders and Treatments
- Otitis Media and Relapsing Polychondritis
Guy's Hospital
2020-2022
King's College London
2020-2022
Guy's and St Thomas' NHS Foundation Trust
2019-2021
University College London
2014
The Royal Free Hospital
2014
Royal Free London NHS Foundation Trust
2014
Royal Marsden NHS Foundation Trust
2012
The long-term trajectory of kidney function recovery or decline for survivors critical illness is incompletely understood. Characterising changes in after and associated episodes acute injury (AKI), could inform strategies to monitor treat new progressive chronic disease. We assessed estimated glomerular filtration rate (eGFR) impact AKI 1301 care with 5291 eGFR measurements (median 3 [IQR 2, 5] per patient) between hospital discharge (2004-2008) end 7 years follow-up. Linear mixed effects...
Background Epithelioid hemangioendothelioma (EHE) is an ultra-rare, vascular sarcoma with clinical presentation ranging from indolent to aggressive form. Over 50% of patients present metastatic disease, requiring systemic therapy, although no therapies are specifically approved for EHE. Retrospective evidence supports the activity mTOR inhibitors (e.g. sirolimus), available only off-label. EHE and advocates therefore working support approval effective treatments by collecting data on patient...
Purpose: Epithelioid hemangioendothelioma (EHE) is an ultra-rare vascular sarcoma with unique clinical features. EHE characterized by unpredictable, often protracted, course and highly variable presentation. Due to difficulty recruiting cancer patients, health-related quality of life (HRQoL) patients has not yet been studied. The aim this study was assess symptom burden its impact on HRQoL psychological distress.Methods: initiated after patients' foundations approached our research group...
Background Anticoagulants induce atherosclerosis regression in animal models but exploiting this clinically is limited by bleeding events. Here we test a novel thrombin inhibitor, PTL060, comprising hirulog covalently linked to synthetic myristoyl electrostatic switch tether cell membranes. Methods and Results ApoE-/- mice were fed chow or high-fat diets, before transplantation of congenic aortic segments injection parental hirulog, control saline, labeled CD11b positive cells. Aortic...
Delayed-type hypersensitivity (DTH) responses underpin chronic inflammation. Using a model of oxazolone-induced dermatitis and combination transgenic mice, adoptive cell transfer, selective agonists/antagonists against protease activated receptors, we show that PAR-1 signaling on macrophages by thrombin is required for effective granuloma formation. BM-derived (BMMs) in vitro, induced (a) downregulation membrane reverse cholesterol transporter ABCA1 (b) increased expression IFNγ receptor...
Where available, antiretrovirals (ARVs) and antenatal HIV testing care have significantly reduced mother to child transmission (MTCT). Higher maternal viral load (VL) is linked with higher risk of MTCT, increasing MTCT for women starting ARVs during pregnancy compared those already suppressed. A single-centre, retrospective cohort from 2004 till 2013. Demographic, obstetric virological data, neonatal outcomes were collected where available. 60 pregnancies recorded (in 56 women) in...
Objective Epithelioid haemangioendothelioma (EHE) is an ultrarare vascular sarcoma with incidence of <1/million/year and a large clinical heterogeneity. Data on supportive care needs rare cancer patients are scarce. This study aimed to investigate the level EHE its association sociodemographic, symptom burden characteristics. Methods We present secondary data cross-sectional questionnaire involving recruited from international Facebook group. were collected using web-based PROFILES registry....
Severe and life-threatening hypercalcaemia can develop in haemodialysis patients dialysed against a dialysate with high calcium concentration, the so-called hard water syndrome. Here we describe development of syndrome 30 following sequential failure reverse osmosis unit softeners. Serum levels rose from 2.43 ± 0.19 to 3.92 0.51 mmol/L after exposure. All required emergency four acutely deteriorated, one whom was 24 weeks pregnant. This is largest reported series affected by this rare severe...
A 72-year-old female with a history of autoim-mune hepatitis-related cirrhosis, osteoporosis, andhypertension was admitted recurrent episodesof confusion and drowsiness over the course twoyears. On each occasion, patient demonstratedfluctuating diso-rientated to time place. marked liver flap waspresent on examination no other features he-patic decompensation. These episodes were associat-ed raised serum ammonia levels, normalneuroimaging findings suggest aprecipitating illness. They became...
Background Tissue factor (TF) generates proteases that can signal through PAR-1 and PAR-2. We have previously demonstrated signalling primes innate myeloid cells to be exquisitely sensitive interferon-gamma (IFNγ). In this work we explored how TF mediated PAR-2 modulated responsiveness IFNγ investigated the interplay between PAR-1/-2 on macrophages. Methodology characterised influenced sensitivity in vitro using PCR flow cytometry. it oxazolone-induced delayed type hypersensitivity (DTH)...
Introduction Epithelioid hemangioendothelioma (EHE) is an ultra-rare sarcoma, marked by distinctive molecular and pathological features with a variable clinical behavior. Its natural history still partially understood, reliable prognostic predictive factors are lacking many questions open on the optimal management. In context of EURACAN, prospective registry specifically dedicated to EHE was developed launched aim providing, through high-quality data collection, better understanding this...
<h3>Introduction</h3> Interventions, including commencement of antiretroviral therapy (ARV), have decreased the rate MTCT to less than 1%. This study looks at women who commenced ARV during pregnancy as this group may be high risk MTCT. <h3>Methods</h3> A retrospective cohort HIV-positive commencing a London teaching hospital from January 2004–December 2013. <h3>Results</h3> Complete data sets were obtained 55 pregnant women, (total 59 pregnancies). Median age diagnosis HIV was 30.5...