A5080681210- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Neuroscience and Neural Engineering
- Neurological Disease Mechanisms and Treatments
- Biochemical Analysis and Sensing Techniques
- Neurotransmitter Receptor Influence on Behavior
- Graphite, nuclear technology, radiation studies
- Photoreceptor and optogenetics research
- Advanced MRI Techniques and Applications
- Nuclear and radioactivity studies
- Neural dynamics and brain function
- Ion channel regulation and function
- Spaceflight effects on biology
- Transcranial Magnetic Stimulation Studies
- Receptor Mechanisms and Signaling
- Neurogenesis and neuroplasticity mechanisms
Instituto Cajal
2014-2025
Biomedical Research Networking Center on Neurodegenerative Diseases
2020-2025
Instituto de Salud Carlos III
2018-2025
Consejo Superior de Investigaciones Científicas
2014-2024
Centro de Investigación Biomédica en Red
2018
Numerous studies indicate an association between neurodegenerative and metabolic diseases. Although still a matter of debate, growing evidence from epidemiological animal that preexisting diabetes increases the risk to develop Parkinson's disease. However, mechanisms such are unknown.
In toxin-based models of Parkinson's disease (PD), striatal projection neurons (SPNs) exhibit dendritic atrophy and spine loss concurrent with an increase in excitability. Chronic l-DOPA treatment that induces dyskinesia selectively restores density excitability indirect pathway SPNs (iSPNs), whereas hyperexcitability persist direct (dSPNs). These alterations have only been characterized PD, raising the possibility they are artifact exposure to toxin, which may engage compensatory mechanisms...
ABSTRACT At cellular and circuit levels, drug addiction is considered a dysregulation of synaptic plasticity. In addition, dysfunction the glutamate transporter 1 (GLT‐1) in nucleus accumbens (NAc) has also been proposed as mechanism underlying addiction. However, impact GLT‐1 alterations NAc remain unclear. Here we show that 10 days withdraw after 5 treatment with cocaine or amphetamine decreases expression astrocytes, which results prolongation excitatory postsynaptic potential (EPSP)...
Abstract Dopamine receptors play an important role in motivational, emotional, and motor responses. In addition, growing evidence suggests a key of hippocampal dopamine learning memory. It is well known that associative synaptic plasticity CA3-CA1 requires the D1 receptor (D1R). However, specific D2 (D2R) on memory-related neuroplasticity processes still undefined. Here, by using two models D2R loss, knockout mice (Drd2−/−) with intrahippocampal injections Drd2-small interfering RNA...
Dopaminergic afferents innervate spiny projection neurons (SPNs) in the striatum, maintaining basal ganglia activity. The loss of striatal innervation is hallmark Parkinson's disease (PD), which characterized by dopaminergic denervation. A lack dopamine dorsal striatum induces plasticity changes SPNs. However, PD-associated denervation progressive, and how modified partially innervated areas poorly understood. most studied models PD are based on use neurotoxins that induce an almost complete...
Abstract Background Dopamine transmission is involved in the maintenance of structural plasticity direct‐pathway and indirect‐pathway striatal projection neurons (d‐SPNs i‐SPNs, respectively). The lack dopamine Parkinson's disease produces synaptic remodeling both types SPNs, reducing length dendritic arbor spine density increasing intrinsic excitability. Meanwhile, elevation levels by levodopa recovers these alterations selectively i‐SPNs. However, little known about specific role D1...
L-DOPA-induced dyskinesia (LID) remains a major complication of Parkinson's disease management for which better therapies are necessary. The contribution the striatonigral direct pathway to LID is widely acknowledged but whether striatopallidal involved debated. Selective optogenetic stimulation axon terminals induces in mice rendered hemiparkinsonian with toxin 6-hydroxydopamine (6-OHDA). Here we show that optogenetically-induced increased by D2-type dopamine receptor agonist quinpirole....
SUMMARY Neurons have the unique ability to integrate synaptic information by modulating function of voltage-gated membrane ion channels, which govern their excitability. Astrocytes play active roles in function, from synapse formation and maturation plasticity processes. However, it remains elusive whether astrocytes can impact neuronal activity regulating conductances that control intrinsic firing properties. Here, we found astrocytes, releasing adenosine, enhance slow Ca 2+- activated K +...
Abstract Voltage‐gated Ca V 2.1 (P/Q‐type) 2+ channels play a crucial role in regulating neurotransmitter release, thus contributing to synaptic plasticity and processes such as learning memory. Despite their recognized importance neural function, there is limited information on potential involvement neurodegenerative conditions Alzheimer's disease (AD). Here, we aimed explore the impact of AD pathology density nanoscale compartmentalization hippocampus association with GABA B receptors....
Abstract Parkinson's disease is a progressive neurodegenerative disorder whose symptoms appear in longitudinal temporal pattern along the neuropathological burden. Before motor impairment, most patients suffer anxiety/depression, common and disabling emotional comorbidities. The anatomical functional bases of these comorbidities are not well established, though some studies find that dorsal raphe (DRN) locus coeruleus (LC) nuclei affected by Lewy pathology at early stages when affective...