A5026039606- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Forensic Toxicology and Drug Analysis
- Neurological disorders and treatments
- Cannabis and Cannabinoid Research
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- Genomics, phytochemicals, and oxidative stress
- Cardiovascular Function and Risk Factors
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
- Botulinum Toxin and Related Neurological Disorders
- Psychedelics and Drug Studies
- Neurogenesis and neuroplasticity mechanisms
- Tryptophan and brain disorders
Consejo Superior de Investigaciones Científicas
2009-2022
Instituto de Salud Carlos III
2009-2022
Instituto Cajal
2009-2022
Biomedical Research Networking Center on Neurodegenerative Diseases
2009-2018
Centro de Investigación Biomédica en Red
2009
Abstract Oxidative stress that correlates with damage to nigrostriatal dopaminergic neurons and reactive gliosis in the basal ganglia is a hallmark of methamphetamine (METH) toxicity. In this study, we analyzed protective role transcription factor Nrf2 (nuclear factor‐erythroid 2‐related 2), master regulator redox homeostasis, METH‐induced neurotoxicity. We found deficiency exacerbated dopamine neurons, shown by an increase loss tyrosine hydroxylase (TH)‐ transporter (DAT)‐containing fibers...
Parkinson's disease (PD) is a neurodegenerative disorder predominantly affecting the elderly. The aetiology of not known, but age and environmental factors play an important role. Although more than dozen gene mutations associated with familial forms have been described, fewer 10% all cases can be explained by genetic abnormalities. molecular basis loss dopamine in basal ganglia (caudate/putamen) due to degeneration dopaminergic neurons substantia nigra, which leads motor impairment...
Methamphetamine (METH), a commonly abused psychostimulant, causes dopamine neurotoxicity in humans, rodents, and nonhuman primates. This study examined the selective neuroanatomical pattern of dopaminergic induced by METH mouse striatum. We effect on tyrosine hydroxylase (TH) transporter (DAT) immunoreactivity different compartments striatum nucleus accumbens. The levels its metabolites, 3,4-dihidroxyphenylacetic acid homovanillic acid, as well serotonin (5-HT) metabolite,...