A5061485162- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Transplantation: Methods and Outcomes
- Chemotherapy-induced cardiotoxicity and mitigation
- Mechanical Circulatory Support Devices
- Congenital heart defects research
- Aortic Disease and Treatment Approaches
- Cardiac pacing and defibrillation studies
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Childhood Cancer Survivors' Quality of Life
- Kawasaki Disease and Coronary Complications
- Congenital Diaphragmatic Hernia Studies
- Coenzyme Q10 studies and effects
- Organ Transplantation Techniques and Outcomes
- Heart Failure Treatment and Management
- Cardiovascular and exercise physiology
- Hemodynamic Monitoring and Therapy
- Cancer-related cognitive impairment studies
- Renal Transplantation Outcomes and Treatments
- Ultrasound in Clinical Applications
- Genomics and Rare Diseases
- Mitochondrial Function and Pathology
- Abdominal Trauma and Injuries
National University of Singapore
2018-2025
National University Health System
2018-2025
National Heart Centre Singapore
2023
Khoo Teck Puat Hospital
2021-2023
National University Hospital
2023
Genome Institute of Singapore
2022
Agency for Science, Technology and Research
2022
KK Women's and Children's Hospital
2006-2021
Hospital for Sick Children
2013-2015
SickKids Foundation
2015
BACKGROUND: Sacubitril/valsartan, an angiotensin receptor-neprilysin inhibitor (ARNI), is established treatment for heart failure (HF) with reduced left ventricular ejection fraction. It has not been rigorously compared angiotensin-converting enzyme inhibitors in children. PANORAMA-HF (Prospective Trial to Assess the Angiotensin Receptor Blocker Neprilysin Inhibitor LCZ696 Versus Angiotensin-Converting Enzyme Medical Treatment of Pediatric HF) a randomized, double-blind trial that evaluated...
It is unclear whether the myocardium undergoes accelerated fibrotic remodeling in children after heart transplantation (HTx).In this prospective study, cardiac magnetic resonance (CMR) studies 17 patients 1.3 years (median, range 0.03-12.6 years) HTx (mean age, 9.8 ± 6.2 years; 8 girls) were compared to CMR 9 healthy controls 12.4 2.4 4 girls). T1 measurements performed at a midventricular short axis slice before (ie, native times) and application of 0.2 mmol/kg gadopentetate dimeglumine...
Studies have suggested the effect of blood flow forces in pathogenesis and progression some congenital heart malformations. It is therefore interest to study fluid mechanic environment malformed prenatal heart, such as tetralogy Fallot (TOF), especially when little known about fetal TOF. In this study, we performed patient-specific ultrasound-based simulations three TOF seven normal human hearts. right ventricles (RVs) had smaller end-diastolic volumes (EDVs) but similar stroke (SVs),...
Aim: We explored the association between preoperative anthropometry and biochemistry, postoperative outcomes in infants with CHD after cardiac surgery, as congenital heart disease (CHD) often have feeding difficulties malnutrition. Methodology This was a retrospective review of (≤ 1-year-old) who underwent surgery. Preoperative anthropometryin terms weight-for-age z-score (WAZ), length-for-age (LAZ), well serum albumin hemoglobin concentrations, were evaluated against 6-month mortality,...
There is increasing evidence that de novo anti-HLA antibodies, more specifically donor-specific antibodies (DSA) following solid organ transplantation may be associated with negative outcomes including rejection in the first year and graft loss. Limited data are available pediatric heart transplant recipients. We sought to prospectively determine incidence, class early impact of a cohort Serial panel reactive antibody testing posttransplant was performed 25 patients (14 males) transplanted...
Pediatric myocarditis is a known cause of dilated cardiomyopathy and associated with significant mortality. Our primary objective was to describe the frequency presenting symptoms, signs, investigation results among children diagnosed acute myocarditis. secondary review these patients' initial diagnoses by emergency physicians.This retrospective chart all patients younger than 16 years who were in our hospital over 10-year period (January 2001 December 2010). The symptoms signs stratified...
Kawasaki disease is a febrile illness characterised by systemic inflammation of small- and medium-sized blood vessels which commonly occurs in young children. Although self-limiting, there risk developing coronary artery lesions as progresses with delay diagnosis treatment. Unfortunately, the KD continues to remain clinical dilemma. Thus, this article not only summarises key research gaps associated KD, but also evaluates possibility using circulating endothelial injury biomarkers such as,...
Unlike adult patients, the utility of cardiopulmonary exercise testing (CPET) in children as a prognostic tool is unclear. We sought to examine associations CPET with outcomes dilated cardiomyopathy (DCM).This was single-center, retrospective review DCM who underwent CPET. The primary endpoint for this study time-dependent composite outcome hospitalization management decompensated heart failure, initiation mechanical circulatory support, transplant, or death.We examined 52 at median age 12.6...
Objectives: Kikuchi disease is a benign, self‐limiting condition of unknown aetiology, often manifesting as cervical lymphadenopathy and fever. The usually manifests itself in adulthood paediatric reports are uncommon. aims this study to report the features local population, raise awareness entity among clinicians involved treating these children. Methods: This retrospective series nine cases treated KK Women's Children's Hospital, Singapore. clinical presentation, subsequent course...
Abstract Background Biomechanical stimuli are known to be important cardiac development, but the mechanisms not fully understood. Here, we pharmacologically disrupted biomechanical environment of wild‐type zebrafish embryonic hearts for an extended duration and investigated consequent effects on function, morphological gene expression. Results Myocardial contractility was significantly diminished or abolished in treated 72 hours from 2 dpf with 2,3‐butanedione monoxime (BDM). Image‐based...
Background: Anthracyclines are widely used to treat childhood cancers; however, they cause cardiotoxicity. To address the paucity of clinical data from Asian populations, this study investigated epidemiology pediatric anthracycline-induced cardiotoxicity, during and after chemotherapy, in a multiethnic population. Procedure: This was single-center, retrospective analysis 458 anthracycline-treated oncology patients at KK Women's Children's Hospital, tertiary children's hospital Singapore 2005...
Abstract Infants listed for heart transplantation experience high waitlist and early post‐transplant mortality, thus, optimal allocation of scarce donor organs is required. Unfortunately, the creation validation multivariable regression models to identify risk factors generate individual‐level predictions are challenging. We sought explore use data mining methods a prediction model. CART analysis was used create model which, at time listing, would predict which infants survive least 3 months...
Variable penetrance and late-onset phenotypes are key challenges for classifying causal as well incidental findings in inherited cardiac conditions. Allele frequencies of variants ancestry-specific populations, along with clinical variant analysis interpretation, critical to determine their true significance.Here, we carefully reviewed classified genes associated conditions based on a population whole-genome sequencing cohort 4810 Singaporeans representing Southeast Asian...
Background. Since oxygen saturation from pulse oximetry (SpO2) and partial pressure of arterial (PaO2) are observed to improve immediately after surgical correction cyanotic congenital heart disease (CHD), we postulate that cerebral (CrO2) somatic (SrO2) also improves post-correction. We aim prospectively examine CrO2 SrO2, before, during as well on hospital discharge in children with CHD determine if when these variables increase. Methods. This is a prospective observational trial....
Abstract A case of traumatic haemopericardium, sustained after blunt thoracic trauma, is described in a paediatric patient that was successfully drained by needle pericardiocentesis under 2D‐echocardiographic guidance, via an intercostal approach, the Children's Intensive Care Unit. The haemodynamically unstable with obvious signs cardiac tamponade. Drainage haemopericardium resulted immediate improvement haemodynamics. There no re‐accumulation haemopericardium. were complications as result...
Doxorubicin is an anthracycline widely used for the treatment of various cancers; however, drug has a common deleterious side effect, namely dose-dependent cardiotoxicity. increases generation reactive oxygen species, which leads to oxidative stress in cardiac cells and ultimately DNA damage cell death. The most lesion produced by 7,8-dihydro-8-oxoguanine (8-oxoguanine), enzyme responsible its repair 8-oxoguanine glycosylase (OGG1), base excision enzyme. Here, we show that OGG1 deficiency no...
Abstract Tetralogy of Fallot (TOF) is a congenital heart anomaly that causes drastic reduction in the oxygen level. In this study, we coupled lumped‐parameter model with patient‐specific three‐dimensional (3D) which included modified Blalock‐Taussig (MBT) shunt. By forming closed loop, investigated effects certain parameters on flow rates and pressures at different locations developed network. A local sensitivity analysis an initial zero‐dimensional (0D) closed‐loop was conducted. The 0D...