A5037345613- Corneal Surgery and Treatments
- dental development and anomalies
- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- Developmental Biology and Gene Regulation
- Cancer-related gene regulation
- Skin and Cellular Biology Research
- Bone and Dental Protein Studies
- Cancer-related molecular mechanisms research
- Zebrafish Biomedical Research Applications
- Oral and Maxillofacial Pathology
- Hair Growth and Disorders
- Glaucoma and retinal disorders
- Cell Adhesion Molecules Research
- Wound Healing and Treatments
- Neurobiology and Insect Physiology Research
- Connexins and lens biology
- Retinopathy of Prematurity Studies
- Genetic and rare skin diseases.
- Dental Trauma and Treatments
- Nasolacrimal Duct Obstruction Treatments
- Wnt/β-catenin signaling in development and cancer
- MicroRNA in disease regulation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Academic Publishing and Open Access
Inserm
2007-2025
Institute for Neurosciences of Montpellier
2004-2025
Université de Montpellier
2019-2025
Hôpital Gui de Chauliac
2023-2025
Hôpital Saint Eloi
2004-2024
University of Helsinki
2013-2022
Czech Academy of Sciences, Institute of Biotechnology
2007-2022
Keele University
2017-2018
Life Science Institute
2018
Helsinki Art Museum
2017
Tooth renewal is initiated from epithelium associated with existing teeth. The development of new teeth requires dental epithelial cells that have competence for tooth formation, but specific marker genes these not been identified. Here, we analyzed expression patterns the transcription factor Sox2 in two different modes successional formation: replacement and serial addition primary We observed lamina gives rise to mammals one round as well reptiles continuous replacement. was also...
We report here identification and validation of the first papillomavirus encoded microRNAs expressed in human cervical lesions cell lines. established small RNA libraries from ten associated including cancer two harboring These were sequenced using SOLiD 4 technology. used sequencing data to predict putative viral discovered nine microRNAs. Validation was performed for five candidates, four which successfully validated by qPCR tissue samples lines: HPV 16, one 38 68. The expression 16...
Feathers, like hairs, first appear as primordia consisting of an epidermal placode associated with a dermal condensation that is necessary for the continuation their differentiation. Previously, BMPs have been proposed to inhibit skin appendage formation. We show function specific during feather development more complex. BMP2 and BMP7, which are expressed in both epidermis dermis, involved antagonistic fashion regulating formation condensations, thus subsequent morphogenesis. BMP7 earlier...
Sox2 marks dental epithelial stem cells (DESCs) in both mammals and reptiles, this article we demonstrate several transcriptional mechanisms that regulate cell fate incisor growth. Conditional deletion the oral epithelium results severe craniofacial defects, including impaired proliferation, arrested development abnormal molar development. The murine develops initially but is absorbed independently of apoptosis owing to a lack progenitor proliferation differentiation. Tamoxifen-induced...
The cornea, a transparent tissue covering the eye, is essential for clear vision and represents most densely innervated in body. Its extensive sensory innervation provides both perception crucial trophic support, maintaining corneal health integrity. Disruption of leads to neurotrophic keratitis (NK), pathological condition caused by ocular injury, surgical procedures, or underlying diseases. limited understanding NK pathophysiological mechanisms has hindered development innovative...
The cornea, the transparent outermost layer of eye, possesses exceptional wound healing capabilities essential for vision preservation. complexity corneal microenvironment is central to its rapid healing; however, molecular mechanisms orchestrating this process remain poorly defined, limiting therapeutic advancements. Here, we elucidate extensive remodeling landscape following physical injury. Multi-omics analyses, including transcriptomic, epitranscriptomic, and proteomic profiling, uncover...
The mouse incisor is a valuable but under-utilized model organ for studying the behavior of adult stem cells. This remarkable tooth grows continuously throughout animal's lifetime and houses two distinct epithelial cell niches called labial lingual cervical loop (laCL liCL, respectively). These cells produce progeny that undergo series well-defined differentiation events en route to becoming enamel-producing ameloblasts. During this process, move out niche migrate toward distal tip tooth....
As an element of the lacrimal apparatus, gland (LG) produces aqueous part tear film, which protects eye surface. Therefore, a defective LG can lead to serious eyesight impairment. Up now, little is known about morphogenesis and subsequent maturation. In this study, we delineated elements cellular molecular events involved in formation by using three epithelial markers, namely aSMA, Krt14, Krt19. While aSMA marked restricted population terminal end buds (TEBs) forming LG, Krt14 was found...
ABSTRACT In mice, the incisors grow throughout animal's life, and this continuous renewal is driven by dental epithelial mesenchymal stem cells. Sox2 a principal marker of cells that reside in mouse incisor cell niche, called labial cervical loop, but relatively little known about role Sox2+ population. study, we show conditional deletion embryonic epithelium leads to growth defects impairment ameloblast lineage commitment. Deletion specifically during revealed cellular plasticity rapid...
The transcription factor Sox21 is expressed in the epithelium of developing teeth. present study aimed to determine role tooth development. We found that disruption caused severe enamel hypoplasia, regional osteoporosis, and ectopic hair formation gingiva knockout incisors. Differentiation markers were lost ameloblasts, which formed follicles expressing keratins. Molecular analysis chromatin immunoprecipitation sequencing indicated regulated Anapc10, recognizes substrates for...
Continuous growth of rodent incisors relies on epithelial stem cells (SCs) located in the SC niche called labial cervical loop (LaCL). Here, we found a population apoptotic residing specific location LaCL mouse incisor. Activated Caspase 3 and 9, expressed this colocalized part with Lgr5 putative SCs. The addition inhibitors to ex vivo resulted concentration dependent thickening LaCL. To examine role Wnt signaling regulation apoptosis, exposed postnatal day 2 (P2) incisor BIO, known...
The increase in the size of scientific community created an explosion production. We have analyzed dynamics biomedical output during 1957–2007 by applying a bibliometric analysis PubMed database using different keywords representing specific topics. With assumption that increased interest will result output, we compared topics to all output. This resulted three broad categories topics; those follow general trend show highly variable and attractive which are new grow explosively. citation...
Understanding the control of stem cell (SC) differentiation is important to comprehend developmental processes as well develop clinical applications. Lin28 a conserved molecule that involved in SC maintenance and by regulating let-7 miRNA maturation. However, little known about vivo function Lin28. Here, we report critical roles for lin-28 during oogenesis. We found maturation was increased null mutant fly ovaries. showed female flies displayed reduced fecundity, due defects egg chamber...
Abstract: Pattern recognition is at the heart of clinical dermatology and dermatopathology. Yet, while every practitioner art dermatological diagnosis recognizes supreme value diagnostic cues provided by defined patterns ‘efflorescences’, few contemplate on biological basis pattern formation in skin lesions. Vice versa, developmental theoretical biologists, who would be best prepared to study lesion patterns, are lamentably slow discover this field as a uniquely instructive testing ground...
ABSTRACT A lack of ectodysplasin-A (Eda) signaling leads to dry eye symptoms, which have so far only been associated with altered Meibomian glands. Here, we used loss-of-function (Eda−/−) mutant mice unravel the impact Eda on lacrimal gland formation, maturation and subsequent physiological function. Our study demonstrates that activity is dispensable during embryonic development. However, using a transcriptomic approach, show pathway necessary for proper cell terminal differentiation in...
Abstract The outermost layer of the eye, cornea, is renewed continuously throughout life. Stem cells corneal epithelium reside in limbus at periphery and ensure homeostasis central epithelium. However, young mice, relies on located basal Here, we first studied growth during transition from newborn to adult assessed Keratin 19 (Krt19) expression as a hallmark maturation. Next, set out identify novel marker murine epithelial progenitor before, after maturation, found that Bmi1 expressed cornea...