A5057134708- Psychiatric care and mental health services
- Schizophrenia research and treatment
- Health and Medical Studies
- Clinical practice guidelines implementation
- NMR spectroscopy and applications
- Advanced NMR Techniques and Applications
- Child and Adolescent Health
- Patient-Provider Communication in Healthcare
- bioluminescence and chemiluminescence research
- Chronic Disease Management Strategies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health Systems, Economic Evaluations, Quality of Life
- Psychotherapy Techniques and Applications
- Advanced MRI Techniques and Applications
- Infant Development and Preterm Care
- Liver Disease Diagnosis and Treatment
- Electron Spin Resonance Studies
- Health disparities and outcomes
- Patient Satisfaction in Healthcare
- Family Caregiving in Mental Illness
- Maternal Mental Health During Pregnancy and Postpartum
- DNA Repair Mechanisms
- Mental Health Treatment and Access
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
Fraunhofer Institute for Cell Therapy and Immunology
2017-2024
University Hospital Carl Gustav Carus
2016-2021
TU Dresden
2016-2021
Leipzig University
1994-2019
Universität Ulm
2011-2017
Aalborg University Hospital
2017
San Francisco VA Health Care System
2017
Harvard Stem Cell Institute
2007-2016
Harvard University
2011-2016
Howard Hughes Medical Institute
2011-2016
Abstract Expression of the transcription factors Oct4, Sox2, Klf4, and c-Myc in mesodermal endodermal derivatives, including fibroblasts, lymphocytes, liver, stomach, β cells, generates induced pluripotent stem (iPS) cells. It remains unknown, however, whether cell types ectodermal lineage are equally amenable to reprogramming into iPS cells by same combination factors. To test this, we have isolated genetically marked neural progenitor (NPCs) from neonatal mouse brains infected them with...
The prevalence of hearing loss after damage to the mammalian cochlea has been thought be due a lack spontaneous regeneration hair cells, primary receptor cells for sound. Here, we show that supporting which surround in normal cochlear epithelium, differentiate into new neonatal mouse following ototoxic damage. Using lineage tracing, predominantly outer arise from Lgr5-expressing inner pillar and third Deiters cell generation is increased by pharmacological inhibition Notch. These data...
Tooth renewal is initiated from epithelium associated with existing teeth. The development of new teeth requires dental epithelial cells that have competence for tooth formation, but specific marker genes these not been identified. Here, we analyzed expression patterns the transcription factor Sox2 in two different modes successional formation: replacement and serial addition primary We observed lamina gives rise to mammals one round as well reptiles continuous replacement. was also...
Sox2 expression marks gastric stem and progenitor cells, raising important questions regarding the genes regulated by role of itself during stomach homeostasis disease. By using ChIP-seq analysis, we have found that majority targets in epithelial cells are tissue specific related to functions such as endoderm development, Wnt signaling, cancer. Unexpectedly, is dispensable for cell self-renewal, yet Sox2(+) highly susceptible tumorigenesis an Apc/Wnt-driven mouse model. Moreover, loss...
Intrastriatal administration of mesenchymal stem cells (MSCs) has shown beneficial effects in rodent models Huntington disease (HD). However, the invasive nature surgical procedure and its potential to trigger host immune response may limit clinical use. Hence, we sought evaluate non-invasive intranasal (INA) MSC delivery as an effective alternative route HD. GFP-expressing MSCs derived from bone marrow were intranasally administered 4-week-old R6/2 HD transgenic mice. detected olfactory...
The polymorphism of SLCO1B1 (solute carrier organic anion transporter family, member 1B1), encoding the hepatic uptake transporting polypeptide 1B1, has been associated with increased pravastatin concentrations in single-dose studies. We have investigated whether this influences pharmacokinetics and lipid-lowering efficacy multiple-dose pravastatin.A prospective, parallel-group study 16 healthy volunteers, including 8 carriers an variant haplotype control subjects, was carried out....
The authors treated 16 outpatients and 1 inpatient who had diagnoses of schizophrenia in exacerbation with haloperidol as the sole neuroleptic agent obtained ratings psychopathology serum levels haloperidol. Improvement schizophrenic symptoms measured by Brief Psychiatric Rating Scale was significantly greater patients mean concentrations range 8-18 ng/ml than whose concentration fell outside this range.
Hedgehog signaling plays an important role in embryonic development, organogenesis and cancer. In the adult liver, non-parenchymal cells has been found to play a certain disease states such as fibrosis cirrhosis. However, whether pathway is active mature healthy hepatocytes of significance liver function are controversial. Two types mice with distinct conditional hepatic deletion Smoothened gene, essential co-receptor protein pathway, were generated for investigating hepatocytes. The...
Mesenchymal stem cells (MSCs) show therapeutic efficacy in many different age-related degenerative diseases, including Alzheimer's disease. Very little is currently known about whether or not aging impacts the transplantation efficiency of MSCs. In this study, we investigated distribution intravenously transplanted syngeneic MSCs derived from young and aged mice into young, aged, transgenic APP/PS1 disease mice. male donors were female their pattern was monitored by PCR using Y-chromosome...
Abstract Two different mechanisms of inhibition chemiluminescence in the oxidation luminol by sodium hypochlorite were found. Most substances investigated these experiments acted scavenging NaOCI. This mechanism was independent concentration hydrogen peroxide and incubation time between inhibitors. The most potent inhibitors containing SH groups. Compounds with amino groups as a target for HOCI/OCI − to yield chloramines much less effective Another found catalase. It depended on presence...
Hydrogen peroxide amplifies the chemiluminescence in oxidation of luminol by sodium hypochlorite. A linear relationship between concentration hydrogen and light intensity was found range 5 x 10(-8)-7.5 10(-6) mol/l. At 7.5 mol/l H2O2 is amplified 550-fold. The spectra these reactions have a wavelength maximum at 431 nm independent peroxide. results indicate that necessary component chemiluminescent
The aim of this study was to develop and evaluate a brief quantitative five-language measure involvement satisfaction in clinical decision-making (CDIS) – with versions for patients (CDIS-P) staff (CDIS-S) use mental health services. An English CDIS developed by reviewing existing measures, focus groups, semistructured interviews piloting. Translations into Danish, German, Hungarian Italian followed the International Society Pharmacoeconomics Outcomes Research (ISPOR) Task Force principles...
Close, continuous and efficient collaboration between different professions sectors of care is necessary to provide patient-centered for individuals with mental disorders. The lack structured in- outpatient constitutes a limitation the German health system. Since 2012, new law in Germany (§64b Social code book (SGB) V) has enabled establishment cross-sectoral treatment models psychiatry. Such model projects follow capitation budget, i.e. total per patient budget inpatient psychiatric...
Background: New cross-sectoral mental health care models have been initiated in Germany to overcome the fragmentation of German system. Starting 2013, flexible and integrative psychiatric model projects according §64b SGB V Social Law (FIT64b) implemented. The study “PsychCare” combines quantitative qualitative primary data with routine insurance for evaluation these models. Effects, costs cost-effectiveness from perspectives patients, relatives providers are compared standard care....
Elderly Veterans enrolled in VA Home Based Primary Care (HBPC) programs suffer from many diseases including malnutrition. Nutrition screening tools exist the system but they are inconsistently utilized across ambulatory care and neither research validated nor comparable with non-VA populations. The Mini-Nutritional Assessment short-form (MNA-SF) has been international studies a variety of settings. primary aim this study was to find prevalence malnutrition among HBPC programs. secondary...
Comprehensive data are needed to evaluate the burden of low birthweight. Analysis routine on health-care utilization during early childhood were used test hypothesis that infants with birthweight have (i) increased inpatient utilization, (ii) higher hospital costs and (iii) different morbidity pattern in when compared normal infants. Children born between 2007 2013 insured at birth statutory health insurance AOK PLUS included (N = 118,166, equaling 49% Saxon newborns) classified into very (<...