A5078947324- Proteoglycans and glycosaminoglycans research
- Cardiac Ischemia and Reperfusion
- Signaling Pathways in Disease
- Acute Kidney Injury Research
- Elbow and Forearm Trauma Treatment
- Connective tissue disorders research
- Appendicitis Diagnosis and Management
- Peptidase Inhibition and Analysis
- Sarcoma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Tissue Engineering and Regenerative Medicine
- Orthopedic Surgery and Rehabilitation
- Cardiac Fibrosis and Remodeling
- Anesthesia and Neurotoxicity Research
- Cardiac tumors and thrombi
- Hip and Femur Fractures
- Gallbladder and Bile Duct Disorders
- Sports injuries and prevention
- Hernia repair and management
- Vascular Malformations and Hemangiomas
- Pelvic and Acetabular Injuries
- Congenital heart defects research
- Biliary and Gastrointestinal Fistulas
- Fibroblast Growth Factor Research
Cardiff University
2020-2024
University Hospital of Wales
2023-2024
Cardiff and Vale University Health Board
2024
Aneurin Bevan University Health Board
2022
Royal Gwent Hospital
2012-2022
Nankai University
2021
Institute of Infection and Immunity
2021
Institute of Neurobiology
2020
BackgroundThe most common fractures in children are torus (buckle) of the wrist. Controversy exists over treatment, which ranges from splint immobilisation and discharge to cast immobilisation, follow-up, repeat imaging. This study compared pain function affected offered a soft bandage immediate with those receiving rigid follow-up as per treating centre protocol.MethodsIn this randomised controlled equivalence trial we included 965 (aged 4–15 years) distal radius fracture 23 hospitals UK....
Hyaluronidase (HYAL)-2 is a weak, acid-active, hyaluronan-degrading enzyme broadly expressed in somatic tissues. Aberrant HYAL2 expression implicated diverse pathology. However, significant proportion of enzymatically inactive; thus the mechanisms through which dysregulation influences pathobiology are unclear. Recently, nonenzymatic functions have been described, and nuclear has shown to influence mRNA splicing prevent myofibroblast differentiation. Myofibroblasts drive fibrosis, thereby...
Cardiac myxomas are the most frequent cardiac tumors and cause for significant morbidity mortality. Recent evidence indicates that are, in fact, neoplasms rather than organized thrombi. may present as solitary lesions or association with Carney complex. complex has been linked to chromosome 2p16 PRKAR1A gene at 17q22-24. In this study, we analyzed sporadic evaluate whether genetic alterations seen non associated well. We microdissected material from 13 patients markers PRKAR1 9CA, D2S2153,...
Acute and chronic kidney diseases are a major contributor to morbidity mortality worldwide, with no specific treatments currently available for these. To enable understanding the pathophysiology of testing novel acute disease, suitable in vivo model disease is essential. In this article, we describe two reliable rodent models (rats mice) efficacious injury displaying progression, which also reversible through therapeutic strategies such as ischemic preconditioning (IPC).
ABSTRACT Background The stroma plays a key role during renal development and in regeneration after injury. However, following injury, the expands driving progressive fibrosis. Hyaluronan (HA) is glycosaminoglycan that absent healthy kidney but highly expressed disease. To understand strategies to modulate stromal HA towards therapeutic advantage, this study compares Synthase (HAS) enzyme expression development, health, disease, recovery. Methods Rats underwent ischaemia reperfusion injury...
ABSTRACT Acute Kidney Injury (AKI) is a common cause of Chronic Disease (CKD). The leading AKI worldwide Ischaemia Reperfusion (IRI), seen most commonly in the clinical setting as result sepsis-driven hypotension. We are increasingly recognising, however, that and CKD one closely associated continuum disease, rather than distinct entities. Ischaemic Preconditioning (IPC) strategy aimed at reducing deleterious effects IRI. This study demonstrates an efficacious model kidney IRI, protective...
<h3>Introduction</h3> Up to 20% of patients undergoing cholecystectomy continue experience symptoms. We consider such results unacceptably high and in need further evaluation. Our aim was identify the biliary symptoms for which carried out then determine prevalence nature persistent following procedure a cohort 500 consecutive cases. <h3>Methods</h3> A validated pre-operative survey completed at time listing laparoscopic cholecystectomies (LC), followed by follow-up phone 12 weeks after...
Grigorieva, Irina; Buckby, Sarah; Brown, Charlotte V.; Steadman, Robert; Meran, Soma Author Information