A5102745938- Lung Cancer Diagnosis and Treatment
- Ultrasound in Clinical Applications
- Microbial Metabolic Engineering and Bioproduction
- Pleural and Pulmonary Diseases
- Biofuel production and bioconversion
- Identification and Quantification in Food
- Cancer-related Molecular Pathways
- Genetic diversity and population structure
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Cancer Cells and Metastasis
- Gene Regulatory Network Analysis
- Process Optimization and Integration
- Bioinformatics and Genomic Networks
- Cancer, Hypoxia, and Metabolism
- Lepidoptera: Biology and Taxonomy
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Phytochemistry and Bioactive Compounds
- Breast Cancer Treatment Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Nanoparticle-Based Drug Delivery
- Phytochemical Studies and Bioactivities
- Endoplasmic Reticulum Stress and Disease
- Obesity, Physical Activity, Diet
Guizhou University
2013-2025
Shanghai Pulmonary Hospital
2021-2024
Tongji University
2021-2024
Shanghai Tenth People's Hospital
2021-2023
Peking Union Medical College Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Tongji Hospital
2021
Chinese Academy of Sciences
2013-2021
Kunming Medical University
2021
Center for Excellence in Molecular Cell Science
2021
Injecting carbon dioxide (CO2) into coal seams enhances coalbed methane (CBM) recovery and promotes the CO2 geological sequestration. In this process, reservoir temperature plays a crucial role in interaction between coal. However, microstructural changes of at different saturation temperatures under subcritical (Sub CO2) conditions remain unclear. This study used scanning electron microscopy (SEM), low-temperature N2 adsorption, Fourier transform infrared spectroscopy (FTIR) to analyze...
Abstract Enhanced neovasculogenesis, especially vasculogenic mimicry (VM), contributes to the development of triple-negative breast cancer (TNBC). Breast tumor-initiating cells (BTICs) are involved in forming VM; however, specific VM-forming BTIC population and regulatory mechanisms remain undefined. We find that tumor endothelial marker 8 (TEM8) is abundantly expressed TNBC serves as a for BTICs. Mechanistically, TEM8 increases active RhoC level induces ROCK1-mediated phosphorylation SMAD5,...
Steroidal saponins have long attracted scientific attention, due to their structural diversity and significant biological activities. For example, total steroidal extracted from the rhizome of Paris polyphylla Sm. var. yunnanensis (TSSPs) constitute an effective treatment for abnormal uterine bleeding.To determine active constituents in TSSPs elucidate mechanisms that underlie vivo pharmacologic actions on hemostasis.Steroidal were purified by chromatography, effects upon hemostasis platelet...
Brain metastasis (BM) is common in patients with breast cancer. Predicting patient survival critical for the clinical management of cancer brain (BCBM). The present study was designed to develop and evaluate a prognostic model newly diagnosed BCBM. Based on data BCBM treated Affiliated Hospital Academy Military Medical Sciences (Beijing, China) between 2002 2014, nomogram developed predict using proportional hazards regression analysis. validated internally by bootstrapping, concordance...
Background US has proven valuable in the diagnosis of subpleural pulmonary lesions (SPLs); however, existing indicators have limitations. Purpose To propose and validate a revised contrast-enhanced (CE) indicator for differential benign malignant SPLs to compare its performance with CE diagnostic criteria. Materials Methods This prospective study (Chinese clinical trial registry, ChiCTR1800019828) enrolled patients between May 2019 August 2020. They were divided into developmental cohort...
Background: The consistent definition of sarcopenic obesity (SO) is limited, its association with mild cognitive impairment (MCI) has not been clarified. Objective: This study aimed to evaluate the prevalence and agreement SO using different definitions between MCI. Methods: was diagnosed by co-existence sarcopenia defined Asia Working Group for Sarcopenia (AWGS) body mass index (BMI), visceral fat area (VFA), waist circumference (WC), or percentage (BF%). Cohen’s kappa used assess...
To develop and prospective validate an ultrasound (US) prediction model to differentiate between benign malignant subpleural pulmonary lesions (SPLs).
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults with high metastasis rates. The O6-methylguanine DNA methyl transferase (MGMT) involved chemoresistance of Dacarbazine (DTIC) treatment. Our previous study found that combination oncolytic adenovirus H101 and DTIC treatment UM cells shows a synergistic antitumor effect mainly though down-regulation MGMT. MGMT knockdown by shRNAs increases sensitivity uveal to protein hemostasis important for DTIC. Tripartite...
Abstract Objective To evaluate the accuracy and safety of contrast-enhanced ultrasound (CEUS) guided biopsy in diagnosis radiologically determined pleural based lesions. Method A prospective study was conducted on patients with Patients who met inclusion criteria received by CEUS to obtain specimens, followed histomathological microbiological examinations. After treatment follow-up, surgical thoracoscopy performed cases undefinite diagnosis. Result total 460 were finally included. showed...
Aim: To analyze the efficacy and toxicity of stereotactic body radiotherapy (SBRT) versus intensity-modulated (IMRT) in stage III patients with ultra-central squamous non-small-cell lung cancer (sqNSCLC). Methods: Forty-four sqNSCLC receiving SBRT (n = 15) or IMRT 29) between December 2014 August 2017 were reviewed. Results: At a median follow-up 16.5 months, 1-year local control rate was 60.8 37.5%, respectively (p 0.23); overall survival 17 18 months 0.48); ≥3 grade 20 24.1% 0.83)....
In high-risk human papillomavirus (HR-HPV)-positive cervical cancer, E6-associated protein (E6AP), an E3 ubiquitin ligase, mediates the ubiquitination and proteasomal degradation of tumor suppressor p53. Here, we addressed question whether caffeic acid phenethyl ester (CAPE), a natural product mainly derived from propolis, can disrupt interaction between E6AP p53, inhibit p53 exhibit anti-cervical cancer activity.The ability CAPE to growth induce apoptosis was shown in HR-HPV-positive cell...
To explore the clinical value of contrast-enhanced ultrasound (CEUS) in differential diagnosis benign and malignant subpleural pulmonary lesions (SPLs).Among 959 patients with SPLs who were scheduled to undergo ultrasound-guided puncture our department between January 2019 June 2019, 506 included their B-mode CEUS features, including lesion's location, size, margin, echo, perfusion pattern contrast agent, degree enhancement, homogeneity, vascular signs, necrosis, retrospectively...
Lung cancer is a leading cause of mortality worldwide and shows substantial clinical biomolecular heterogeneity. Currently, specific therapeutic strategies are lacking, so effective drug targets urgently needed. E6AP/UBE3A multifaceted ubiquitin ligase that controls various signaling pathways implicated in neurological diseases cancers; however, its role lung incompletely understood. Here, MCM6 was identified as an interacting partner E6AP using the yeast two-hybrid assay. MCM2 MCM4 were...
The impact degree is a measure of the robustness metabolic network against deletion single or multiple reaction(s). Although such useful for mining important enzymes/genes, it was defined only networks without cycles. In this paper, we extend containing cycles and develop simple algorithm to calculate degree. Furthermore improve reduce computation time by deletions reactions. We applied our method E. coli, that includes reference pathways, consisting 3281 reaction nodes 2444 compound nodes,...
To develop and validate an individualized nomogram for differentiating the histologic subtypes (adenocarcinoma squamous cell carcinoma) of subpleural non-small lung cancer (NSCLC) based on ultrasound parameters clinical data.
Analysis of the robustness a metabolic network against single or multiple reaction(s) is useful for mining important enzymes/genes. For that purpose, impact degree was proposed by Jiang et al. In this short paper, we extend networks containing cycles and develop simple algorithm its computation. Furthermore, propose an improved computing degrees deletions reactions. The results preliminary computational experiments suggest several tens times faster than algorithm.
Abstract Increasing evidence has demonstrated that breast cancers are driven by a cellular subset displays stem cell properties. These cells mediate tumor metastasis and contribute to therapeutic resistance. We recently reported cancer (BCSCs) capable of inter-converting between two states in process regulated the microenvironment. CD44+/CD24- CSCs characterized expression epithelial-mesenchymal transition (EMT) genes, invasive largely quiescent, whereas mesenchymal-epithelial-like (MET)...