A5028423271- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Histone Deacetylase Inhibitors Research
- Circadian rhythm and melatonin
- Cannabis and Cannabinoid Research
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Pancreatic function and diabetes
- Immune cells in cancer
- Drug Transport and Resistance Mechanisms
- CAR-T cell therapy research
- Nuclear Receptors and Signaling
- Mercury impact and mitigation studies
- Ion Channels and Receptors
- Immunotherapy and Immune Responses
- Urban Green Space and Health
- Air Quality and Health Impacts
- Sphingolipid Metabolism and Signaling
- Chemokine receptors and signaling
- Atherosclerosis and Cardiovascular Diseases
- Protein Degradation and Inhibitors
- Identification and Quantification in Food
- Climate Change and Health Impacts
- NF-κB Signaling Pathways
- Melamine detection and toxicity
University of Copenhagen
2021
Medical University of Vienna
2017-2020
Medical University of Graz
2012-2015
GlaxoSmithKline (United Kingdom)
2013
Johannes Kepler University of Linz
2009
The G protein–coupled receptor 55 (GPR55) is a lysophosphatidylinositol (LPI) that also responsive to certain cannabinoids. Although GPR55 has been implicated in several (patho)physiologic functions, its role remains enigmatic owing mainly the lack of selective antagonists. Here we show compound CID16020046 ((4-[4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1<i>H</i>,4<i>H</i>,5<i>H</i>,6<i>H</i>-pyrrolo[3,4-c]pyrazol-5-yl] benzoic acid) antagonist. In yeast cells expressing human GPR55,...
Background and Purpose Tumour cell migration adhesion constitute essential features of metastasis. G‐protein coupled receptor 55 (GPR55), a lysophospholipid receptor, has been shown to play an important role in carcinogenesis. Here, we investigated the involvement GPR55 metastasis colon cancer cells. Experimental Approach Adhesion assays using highly metastatic line HCT116 vivo assay liver were performed. The antagonist CID16020046, cannabidiol, putative siRNA used block activity Key Results...
An easy to employ method for the determination of melamine in milk powder samples using CZE with either UV or MS detection is presented. The separation capabilities allowed keeping sample preparation rather simple. Before analysis, were dissolved water, de-fatted dichloromethane and diluted ACN precipitate protein, filtrated injected without further pretreatment. developed down a level 0.50 mg/kg 0.25 when ESI quadrupole/TOF was employed detection.
Some effector CD4+ T cell subsets display cytotoxic activity, thus breaking the functional dichotomy of helper and CD8+ lymphocytes. However, molecular mechanisms regulating lymphocyte (CD4+ CTL) differentiation are poorly understood. Here we show that levels histone deacetylases 1 2 (HDAC1-HDAC2) key determinants CTL differentiation. Deletions both Hdac1 Hdac2 alleles (HDAC1cKO-HDAC2HET) in cells induced a program was controlled by IFN-γ-JAK1/2-STAT1 signaling. In vitro, activated...
Invariant natural killer T (iNKT) cells represent a subgroup of innate-like and play an important role in immune responses against certain pathogens. In addition, they have been linked to autoimmunity antitumor immunity. iNKT consist several subsets with distinct functions; however, the transcriptional networks controlling subset differentiation are still not fully characterized. Myc-associated zinc-finger-related factor (MAZR, also known as PATZ1) is essential transcription for CD8