A5091430741- Trace Elements in Health
- Diet and metabolism studies
- Bipolar Disorder and Treatment
- Pharmacological Effects and Toxicity Studies
- Folate and B Vitamins Research
- Pregnancy and Medication Impact
- Plant Micronutrient Interactions and Effects
- Adipose Tissue and Metabolism
- Nutritional Studies and Diet
- Prenatal Substance Exposure Effects
- Diet, Metabolism, and Disease
- Aldose Reductase and Taurine
- Organ Donation and Transplantation
- Fatty Acid Research and Health
- Sodium Intake and Health
- Kidney Stones and Urolithiasis Treatments
- Iron Metabolism and Disorders
- Muscle metabolism and nutrition
- Eicosanoids and Hypertension Pharmacology
- Cancer, Hypoxia, and Metabolism
- Metabolism and Genetic Disorders
- Vitamin C and Antioxidants Research
- Lipid metabolism and biosynthesis
- Myasthenia Gravis and Thymoma
- Heme Oxygenase-1 and Carbon Monoxide
Kiel University
2016-2024
University of Regensburg
2007
Ruhr University Bochum
1999
Universitätskinderklinik
1999
The mammalian target of rapamycin (mTOR) has become an interesting for cancer therapy through its influence on oncogenic signals, which involve phosphatidylinositol-3-kinase and hypoxia-inducible factor-1alpha (HIF-1alpha). Since mTOR is upstream regulator HIF-1alpha, a key mediator gastric growth angiogenesis, we investigated activation in human adenocarcinoma specimens determined whether could inhibit mice. Expression phospho-mTOR was assessed by immunohistochemical analyses tissues. For...
Astaxanthin is a coloring agent which used as feed additive in aquaculture nutrition. Recently, potential health benefits of astaxanthin have been discussed may be partly related to its free radical scavenging and antioxidant properties. Our electron spin resonance (ESR) trapping data suggest that synthetic potent scavenger terms diphenylpicryl-hydrazyl (DPPH) galvinoxyl radicals. Furthermore, dose-dependently quenched singlet oxygen determined by photon counting. In addition quenching...
<b><i>Objective:</i></b> Mutation analysis of the acetylcholine receptor (AChR) ε subunit gene in patients with sporadic or autosomal recessive congenital myasthenic syndromes (CMS). <b><i>Background:</i></b> The nicotinic AChR skeletal muscle is a neurotransmitter-gated ion channel that mediates synaptic transmission at vertebrate neuromuscular junction. Mutations its may cause syndromes. A recently described mutation exon 12 (ε1267delG) disrupts cytoplasmic loop and fourth transmembrane...
Background Ahiflower oil from the seeds of Buglossoides arvensis is rich in α-linolenic acid (ALA) and stearidonic (SDA). ALA SDA are potential precursor fatty acids for endogenous synthesis eicosapentaenoic (EPA) docosahexaenoic (DHA), which n3-long chain polyunsaturated (n3-LC-PUFAS), humans. Since taurine, an amino sulfonic acid, often associated with tissues n3-LC-PUFAS (e.g., fish, human retina), taurine may play a role EPA- DHA-metabolism. Objective To examine capacity plant-derived...
Experimental evidence suggests positive effects of boron on health and metabolism, but human data are still scarce. We aimed to identify dietary cardio-metabolic correlates plasma concentrations in the general population.In a community-based sample (n = 899, 57% men, mean age 61 years), (median [IQR]: 33.80 µg/L [25.61; 44.65]) were measured by inductively coupled plasma-mass spectrometry. Overall (PDI), healthy (hPDI), unhealthy (uPDI) plant-based diet indices derived from validated food...
Lithium is an important trace element in human nutrition and medicine. Mineral medicinal waters may represent a significant source of dietary lithium intake.The concentration 360 German mineral 21 determined. Based on systematic screening, three different exhibiting low (1.7 µg L-1 ), medium (171 high (1724 ) concentrations are chosen for acute bioavailability study male healthy volunteers. In Germany, north-east to south-west gradient analyzed observed the 381 tested waters. The water...
Initial evidence suggests that lithium might affect life expectancy and the risk for different disease conditions, but most studies were conducted in patients on medication. Little is known about association of blood levels within physiological range with cardiometabolic factors diet. We measured plasma a community-based sample from Northern Germany (samples taken between 2010 2012). All participants (aged 25–82 years) underwent standardized examinations completed semi-quantitative food...
In chronic kidney disease, proteinuria increases urinary copper excretion, inducing oxidative tubular damage and worsening function. We investigated whether this phenomenon occurred in transplant recipients (KTRs). addition, we studied the associations of excretion with biomarker liver-type fatty-acid binding protein (u-LFABP) death-censored graft failure.This prospective cohort study was performed Netherlands between 2008 2017, including outpatient KTR a functioning for longer than 1 year,...
Lithium (Li) is an important micronutrient in human nutrition, although its exact molecular function as a potential essential trace element has not yet been fully elucidated. It previously shown that several mineral waters are rich and highly bioavailable sources of Li for consumption. Nevertheless, little known about the extent which other beverages contribute to dietary supply. To this end, content 160 different comprising wine beer, soft energy drinks tea coffee infusions was analysed by...
Taurine is a nonproteinogenic amino sulfonic acid in mammals. Interestingly, skeletal muscle unable to synthesize taurine endogenously, and the processing of muscular changes throughout ageing under specific pathophysiological conditions, such as dystrophy. Ageing disease are also associated with altered iron metabolism, especially when there an excess labile iron. The present study addresses question whether connects cytoprotective effects redox homeostasis previously unknown iron-dependent...
Kidney transplant recipients (KTR) are at increased risk of cardiovascular mortality. We investigated whether, in KTR, post-transplantation copper status is associated with the mortality and potential effect modification by sex. In this cohort study, plasma was measured using mass spectrometry extensively-phenotyped KTR a functioning allograft >1-year. Cox regression analyses inclusion multiplicative interaction terms were performed. 660 (53 ± 13 years old, 56% male), median baseline 15.42...
This study examined the effect of exogenous ketone bodies (KB) on oxygen consumption (V̇o
Scope Boron is a trace element that naturally occurs in soil, making mineral and medicinal water important contributors to overall intake. Thus, systematic screening, the mean boron concentrations of 381 German waters are determined. Methods Results analyzed by inductively coupled mass spectrometry (ICP‐MS). Highest values find from southwest Germany. The content positively correlated with concentration most other bulk elements, including calcium, potassium, magnesium, sodium. Mineral either...
Living kidney donation helps to avoid or reduce the time period of dialysis and on waiting lists in patients requiring a new organ. Mini-incision donor nephrectomy (MIDN) shows result better clinical outcome comparison with traditional open (ODN). This study was performed evaluate impact different surgical procedures quality life (QoL) that underwent nephrectomy.The aim detect differences QoL assessed Short Form-36 Version 2 (SF-36v2) questionnaire between MIDN (n = 34) ODN 36). Furthermore,...
Deficiency of the essential trace element selenium is common in kidney transplant recipients (KTR), potentially hampering antioxidant and anti-inflammatory defence. Whether this impacts long-term outcomes KTR remains unknown. We investigated association urinary excretion, a biomarker intake, with all-cause mortality; its dietary determinants.In cohort study, outpatient functioning graft for longer than 1 year were recruited (2008-11). Baseline 24-h excretion was measured by mass...
In a search for potentially modifiable factors to improve long-term outcome among kidney transplant recipients (KTR), we hypothesized that boron exposure is associated with improved in KTR.We determined 24 h urinary excretion using inductively coupled plasma mass spectrometry as measure of 693 stable KTR (57% male, mean age 53y), enrolled the TransplantLines Food and Nutrition Biobank Cohort Study. Dietary intake was assessed validated food-frequency questionnaires.Linear regression analyses...
Beverages are an integral part of human nutrition, yet little is known about their contribution to daily intakes minerals and trace elements in German consumers. Using inductively coupled plasma-mass spectrometry, we determined the concentration five six beverage samples (n = 990, assigned different groups) collected throughout Germany. For a calculation relative mineral supply, available consumption data was combined with our quantitative analysis calculate average groups meet respective...
ABSTRACT Background Long-term high-dose lithium therapy in bipolar disorder is known to adversely affect kidney function. However, recent animal studies have revealed that low amounts of are beneficial for the when it damaged by exposure nephrotoxic compounds, inflammation or oxidative stress. This study aimed investigate whether urinary excretion, reflecting dietary intake, associated with adverse long-term graft outcomes and patient survival. Methods Urinary concentration was measured...
Obwohl die Diagnose mit dem bloßen Auge schwierig sein kann, gibt es bislang nur wenige dermatoskopische Studien zu subungualen Hämorrhagien. Mithilfe der Dermatoskopie haben Mun et al. nun näher untersucht in welchen charakteristischen Merkmalen sich subunguale Hämorrhagien von Melanomen unterscheiden. Br J Dermatology 2013; 168: 1224–1229
Effects of a Protein Optimized Diet Combined with Moderate Resistance Training on the Postoperative Course in Older Patients Hip Fracture