A5028860238- Natural Antidiabetic Agents Studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Advanced Glycation End Products research
- Pregnancy and preeclampsia studies
- Moringa oleifera research and applications
- Diabetes and associated disorders
- Adipose Tissue and Metabolism
- Ethnobotanical and Medicinal Plants Studies
- Ruminant Nutrition and Digestive Physiology
- Trace Elements in Health
- Hibiscus Plant Research Studies
- Fatty Acid Research and Health
- Research on Leishmaniasis Studies
- Phytochemistry Medicinal Plant Applications
- Natural Products and Biological Research
- Diet, Metabolism, and Disease
- Morinda citrifolia extract uses
- Business and Management Studies
- Agricultural and Food Sciences
- Agriculture Sustainability and Environmental Impact
- Cannabis and Cannabinoid Research
- Religion, Gender, and Enlightenment
- Insect Pest Control Strategies
- COVID-19 Impact on Reproduction
Universidade Federal de Viçosa
2025
Universidade Federal de Mato Grosso
2015-2024
Universidade Estadual de Maringá
2024
Universidade Estadual Paulista (Unesp)
2016-2022
Purpose The Hibiscus rosa-sinensis flower is widely used in Brazilian traditional medicine for the treatment of diabetes and has shown antifertility activity female Wistar rats. However, there no scientific confirmation its effect on pregnancy. aim this study was evaluate aqueous extract H. flowers maternal-fetal outcome pregnant rats with diabetes. Methods Diabetes induced by streptozotocin (STZ, 40 mg/kg) virgin, adult, After induction, were mated. distributed into four groups (n minimum =...
Abstract We evaluated the influence of hyperglycemic intrauterine environment and postweaning consumption a high-fat diet (HFD) on glycemia, insulin, lipid, immunological profile rat offspring in adulthood. Female rats received citrate buffer (Control—C) or Streptozotocin (a beta cell-cytotoxic drug to induce diabetes—D) postnatal day 5. In adulthood, these were mated obtain female offspring, who fed standard (SD) HFD from weaning adulthood (n = 10 rats/group). OC/SD OC/HFD represent control...
Bauhinia holophylla, commonly known as "cow's hoof", is widely used in Brazilian folk medicine for the diabetes treatment. Therefore, aim of this study was at evaluating aqueous extract effect holophylla leaves treatment on streptozotocin-induced diabetic rats. Diabetes induced by Streptozotocin (40 mg/Kg) female Wistar Oral administration given to non-diabetic and rats a dose 400 mg/kg during 21 days. On day 17 treatment, Glucose Tolerance Test performed determine area under curve. At end...
Maternal obesity can cause complications for both women and their offspring generations. Therefore, we intended to verify the repercussions of induction transgenerational on biochemical parameters, reproductive performance, congenital anomaly frequency in Wistar rats. Female rats were used from successive The female parental generation (F0, n=10) mated obtain (F1 generation). F1 received a monosodium glutamate (MSG) solution induce (n=07) or vehicle (control, n=06) during neonatal period....
Embryo-fetal exposure to maternal disorders during intrauterine life programs long-term consequences for the health and illness of offspring. In this study, we evaluated whether mild diabetic rats that were given high-fat/high-sugar (HF/HS) diet presented fetal changes at term pregnancy. Female received citrate buffer (non-diabetic-ND) or streptozotocin (diabetic-D) after birth. According oral glucose tolerance test (OGTT), experimental groups ( n = 11 animals/group) composed non-diabetic...
Morinda citrifolia L., also known as Noni, is widely used plant in folk medicine for various therapeutic purposes. However, reports on its effects during pregnancy are limited. Therefore, the objective of this study was to evaluate M. fruit extract maternal performance and fetal development rats. Pregnant Wistar rats (n = 12/group) were treated from gestational days (GD) 0-21 with water (control group) or aqueous at doses 200, 400, 750 mg/kg, orally. During pregnancy, clinical signs...
Hyperglycemia increases glycosylation with O-linked N-acetyl-glucosamine (O-GlcNAc) contributing to placental dysfunction and fetal growth impairment. Our aim was determine how O-GlcNAc levels are affected by hyperglycemia the distribution in different regions.Female Wistar rats were divided into following groups: severe (>300 mg/dL; n = 5); mild (>140 mg/dL, at least than two time points during oral glucose tolerance test; 7) or normoglycemia (<120 6). At 21 days of pregnancy, tissue...
Hancornia speciosa is usually used in Brazilian folk medicine to treat diabetes. The hypothesis of the present study that this medicinal plant exerts beneficial effects on hyperglycemia, preventing diabetic complications. Therefore, aim was evaluate treatment effect aqueous extract H. leaves metabolic parameters rats.The (400 mg/Kg) administered both nondiabetic and severely female Wistar rats by gavage. Oral Glucose Tolerance Test performed area under curve (AUC) estimated day 17 pregnancy....
Diabetes mellitus is a syndrome of great importance that affects an increasing number people every day. In particular, diabetes common and important disease during pregnancy marked by complications, both fetal maternal, increase the risks morbidity mortality for diabetic pregnant women their offspring. Drugs such as insulin hypoglycemic drugs are given to treat diabetes, but regular exercise adequate diet have also been indicated. Furthermore, coadjutant therapies medicinal plants popularly...
This study aims to evaluate the phytochemical properties of Bauhinia holophylla (Bong.) Steud leaf extract, and their impact on maternal reproductive fetal development in diabetic rats. For this, adult female Wistar rats (100 days life) received streptozotocin (40 mg/Kg, intraperitoneal) for induction diabetes, were mated distributed into four groups: Nondiabetic; Nondiabetic given B. holophylla; Diabetic; Diabetic holophylla. The plant extract was by gavage at increasing doses: 200, 400,...
Abstract Background Exercise is commonly recommended to control hyperglycemia, including during pregnancy. We conducted this study understand the potential benefits and risks of exercise pregnancy women with diabetes. Specifically, we evaluated effects swimming on a diabetic rat assayed maternal‐fetal parameters. Methods Diabetes was induced in female newborn from Wistar rats by streptozotocin administration first postnatal day. At 110 days life, after confirm mild symptoms diabetes, were...
The aim of this study was to evaluate the effect Himatanthus sucuuba on maternal reproductive outcome and fetal anomaly incidence in rats. Pregnant rats were randomly divided into three experimental groups as follows: Control = treated with water (vehicle), 250 H. at dose mg/kg, 500 mg/kg. orally treated, by gavage, or vehicle (water) during preimplantation organogenic period (from gestational day 0–14). At 21 pregnancy, all killed obtain maternal–fetal data. treatment mg/kg caused reduction...
While the immunogenic potential of vaccination against infectious diseases was extensively shown, data on safety assessment recombinant proteins in vaccine formulations administered during pregnancy are still scarce. In current study, antigenicity a leishmaniasis (based Leishmania braziliensis protein peroxidoxin) and possible maternal reproductive outcomes fetal anomalies after immunization with leishmanial or adjuvant alone (Bordetella pertussis derived MPLA adjuvant) were assessed. Rats...
Twenty-four Girolando cows (107 ± 56 days in milk, milk yield 22.0 10.25 kg/d, and 529 103 kg body weight) were used a completely randomized design. The divided according to the following experimental diets: 1—CON (basal diet with ground dry corn) 2—RCS (diet total replacement of corn by rehydrated grain silage) 3—RCSP silage + 500 g ton−1 CINBENZA DP100®, NOVUS International, Inc (Chesterfield, Missouri, U.S.A.). enzymatic extract Bacillus licheniformis, protease activity 600 IU g−1). Cows...
Etanercept is a tumor necrosis factor alpha (TNF-α) inhibitor chronically used to treat autoimmune diseases. However, the use of etanercept during pregnancy still needs be further investigated. The aim this study evaluate treatment pregnancy, analyzing maternal reproductive performance, fetal outcomes, and placental repercussions. Wistar rats (200-250 g) were mated randomly distributed into two experimental groups: control (n = 10 animals/group). Treatments with (0.8 mg/kg, s.c.), or saline...
Materials and methods Diabetes was induced by streptozotocin (40 mg/Kg) in virgin female Wistar rats. After diabetes induction, rats were mated. The pregnant diabetic put four experimental groups, with n minimum=12 animals/ group: Non-diabetic; Non-diabetic Treated; Diabetic Treated. Hancornia speciosa leaf aqueous extract (600 mg/kg) daily administered all gestational period. On days 0, 7, 14 21 the glycemia measured. day of pregnancy, anesthetized killed. blood liver collected. biochemical...