A5081697348- Prostate Cancer Treatment and Research
- Hormonal and reproductive studies
- Prostate Cancer Diagnosis and Treatment
- Urinary Bladder and Prostate Research
- Multiple Myeloma Research and Treatments
- Tryptophan and brain disorders
- Polysaccharides and Plant Cell Walls
- Cancer Immunotherapy and Biomarkers
- Sphingolipid Metabolism and Signaling
- Genital Health and Disease
- Muscle metabolism and nutrition
- Pharmacology and Obesity Treatment
- Stress Responses and Cortisol
- Testicular diseases and treatments
- Sexual function and dysfunction studies
- Cancer Diagnosis and Treatment
Kawasaki Medical School
2022-2024
Abstract Objective To evaluate the real-world clinical usage and effectiveness of apalutamide in men with nonmetastatic castration-resistant prostate cancer (nmCRPC). Methods We retrospectively reviewed data 186 who received across 17 institutions. The primary outcomes were for nmCRPC: prior other androgen receptor signaling inhibitors (ARSIs), radical treatment, distribution prostate-specific antigen (PSA) doubling time (PSA-DT) at initial administration apalutamide. secondary efficacy...
Glycosphingolipids (GSLs) are composed of a polar glycan chain and hydrophobic tail known as ceramide. Together with variation in the chain, ceramides exhibit tissue-specific structural long-chain base (LCB) N-acyl moieties terms carbon length, degree desaturation, hydroxylation. Here, we report GSLs urinary bladders mice humans. Using TLC, showed that major hexosylceramide, lactosylceramide, globotriaosylceramide, globotetraosylceramide, Neu5Ac-Gal-Glc-Ceramide,...
Abstract Testosterone plays an important role in maintaining both physical and mental function. Age‐related testosterone depletion contributes to the development of angina, arteriosclerosis, obesity, metabolic syndrome, dementia, frailty, a range other conditions. A condition involving age‐related associated clinical symptoms is defined as late‐onset hypogonadism (LOH). LOH treated by replacement therapy. Indications for therapy are determined evaluating signs.
Abstract Background Japanese men receiving apalutamide often experience skin-adverse events (AEs), possibly requiring treatment interruption or dose reduction. However, concerns have arisen regarding the impact of these adjustments on efficacy apalutamide. Our study evaluated efficacy, safety, and persistence in with metastatic castration-sensitive prostate cancer (mCSPC). Methods We retrospectively reviewed medical records 108 mCSPC from 14 institutions. The primary outcomes were...
137 Background: Japanese patients with prostate cancer (PC) treated apalutamide often encounter skin-adverse events (AE), which might lead to adjust the initial-dose of apalutamide. However, concerns have emerged regarding potential impact these dose adjustments on overall efficacy in real-world clinical practice. We aimed evaluate association between adjustment and outcome men metastatic castration-sensitive PC (mCSPC). Methods: retrospectively evaluated 108 mCSPC divided into two groups:...