A5102720413- BRCA gene mutations in cancer
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Nutrition, Genetics, and Disease
- Lung Cancer Diagnosis and Treatment
- Genetics, Bioinformatics, and Biomedical Research
- RNA modifications and cancer
- Lung Cancer Research Studies
- CRISPR and Genetic Engineering
- Cancer Diagnosis and Treatment
- Gene expression and cancer classification
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Molecular Biology Techniques and Applications
- Sarcoma Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Chemotherapy-related skin toxicity
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic factors in colorectal cancer
- Cell death mechanisms and regulation
- Image Retrieval and Classification Techniques
- Retinal Development and Disorders
- Epigenetics and DNA Methylation
- Medical Imaging and Pathology Studies
- Multimodal Machine Learning Applications
National Cancer Centre Japan
2024
Keio University
2023-2024
Tokyo National Hospital
1993-2023
National Cancer Center
2019-2023
Jikei University School of Medicine
2019-2020
Komaki City Hospital
2016-2019
National Cancer Center Hospital East
2019
Toho University
2008-2010
In-Q-Tel
2009
The University of Tokyo
1997
Previous clinical trials indicate that 10%-25% of patients received genomically matched therapy after comprehensive genomic profiling (CGP) tests. However, the utility CGP tests has not been assessed in practice. We for advanced or metastatic solid tumor and determined proportion receiving among those with common non-common cancers. From August 2019 to July 2020, a total 418 had undergone tests, results were discussed through molecular board at our site. The median age was 57 (range: 3-86)...
Abstract DNA methylation is an epigenetic modification that results in dynamic changes during ontogenesis and cell differentiation. patterns regulate gene expression have been widely researched. While tools for analysis developed, most of them focused on intergroup comparative within a dataset; therefore, it difficult to conduct cross-dataset studies, such as rare disease studies or cross-institutional studies. This study describes novel method analysis, namely, methPLIER, which enables...
Abstract Background In an extensive genomic analysis of lung adenocarcinomas (LUADs), driver mutations have been recognized as potential targets for molecular therapy. However, there remain cases where target genes are not identified. Super-enhancers and structural variants frequently identified in several hundred loci per case. Despite this, most cancer research has approached the these data sets separately, without merging comparing data, no examples integrated LUAD. Methods We performed...
The volume of medical images stored in hospitals is rapidly increasing; however, the utilization these accumulated remains limited. Existing content-based image retrieval (CBMIR) systems typically require example images, leading to practical limitations, such as lack customizable, fine-grained retrieval, inability search without and difficulty retrieving rare cases. In this paper, we introduce a sketch-based (SBMIR) system that enables users find interest need for images. key concept feature...
PIK3CA mutations are implicated in various cancers, but the implications of multiple concurrent and their orientations within gene have not been fully explored.
The amount of medical images stored in hospitals is increasing faster than ever; however, utilizing the accumulated has been limited. This because existing content-based image retrieval (CBMIR) systems usually require example to construct query vectors; nevertheless, cannot always be prepared. Besides, there can with rare characteristics that make it difficult find similar images, which we call isolated samples. Here, introduce a novel sketch-based (SBMIR) system enables users interest...
Abstract Tumor sensitivity to platinum (Pt)‐based chemotherapy and poly(adenosine diphosphate ribose) polymerase (PARP) inhibitors is increased by homologous recombination deficiency‐causing mutations; in particular, reversion mutations cause drug resistance restoring protein function. Treatment response predicted breast cancer susceptibility gene 1/2 ( BRCA1/2 ) however, have not been comprehensively studied pan‐cancer cohorts. We aimed characterize a large cohort of Japanese patients...
The efficacy and safety of stereotactic radiosurgery (SRS) in comparison with whole brain radiotherapy (WBRT) for metastases (BMs) remains unclear. present study retrospectively reviewed 44 patients who received SRS or WBRT as an initial treatment 10-20 BMs from non-small cell lung cancer between 2009 2016. Of the patients, 24 (54.5%) were treated 20 (45.5%) WBRT. Overall survival (OS), time to intracranial progression (TTIP), neurological (NS), prognostic factors examined. OS did not...
Background: An insertion element IS 3 is flanked by terminal inverted repeat (IR) sequences. encodes two, out‐of‐phase, overlapping open reading frames, orfA and orfB , from which three proteins are produced. OrfAB a transframe protein produced −1 translational frameshifting between it known to be transposase. OrfA OrfB the without frameshifting, but their functions have not been elucidated. Results: A plasmid carrying an mutant that produces only transposase generates miniplasmids—which...
Tyrosine kinase inhibitors (TKIs) are remarkably effective in patients with non-small cell lung carcinoma (NSCLC) harboring driver gene mutations and rearrangements. Crizotinib, a small-molecule TKI, has been demonstrated to be an efficacious drug against c-ros oncogene 1-rearranged NSCLC (ROS1-NSCLC) clinical trials. However, information regarding the use of crizotinib practice Japan is limited.Subjects definite diagnosis advanced/relapsed ROS1-NSCLC were selected from consecutive treated...
HER3 (erbB3) signaling serves an important role in the development and chemoresistance of ovarian cancer, is activated by chemotherapy. To evaluate influence neoadjuvant chemotherapy other clinical factors on expression HER3, as well to examine its a prognostic marker, present study evaluated archived tissues from patients who underwent surgery for cancer between 2011 2018 at our hospital. Immunohistochemical staining was performed using formalin-fixed paraffin-embedded surgical specimens...
Patients with cervical adenocarcinoma (AC) and adenosquamous carcinoma (ASC) have a poorer prognosis than those squamous cell (SCC). Erb-b2 receptor tyrosine kinase 3 (HER3) is member of the epidermal growth factor family its expression associated unfavorable in several cancer types, including SCC cervix. As there limited information on prognostic value HER3 for AC ASC cervix, present study aimed to evaluate impact post-operative recurrence patients This retrospective included 39 early-stage...
Background/Aim: Programmed death-ligand 1 (PD-L1) expression on tumor cells is a predictive biomarker of programmed cell death (PD-1) blockade therapy. This study sought to clarify predictors the efficacy nivolumab in non-small lung cancer (NSCLC) patients with PD-L1 expression-negative tumors. Patients and Methods: We retrospectively reviewed records advanced NSCLC between January 2016 April 2019, investigated marker including status CD8<sup>+</sup> infiltrating lymphocytes (TILs). Results:...
Summary Ocular toxicities arising from anti-cancer drugs occur sporadically and are sometimes underestimated because they not life-threatening. Reports focusing on ocular cancer therapy limited. We investigated the detailed progress of including first-in-class ones. A retrospective review medical records was conducted for patients who were involved in early phase clinical trials with scheduled ophthalmologic examinations according to their protocols between January 2014 August 2021. Patients...
Comprehensive genomic profiling has been approved for use in patients with advanced solid tumours; however, it is only indicated tumour without available standard chemotherapeutic treatment or those who have completed treatments Japan, and there are no data on the clinical feasibility utility of comprehensive treatment-naive patients. This multicentre, single-arm, prospective study aims to evaluate OncoGuide NCC Oncopanel System six major malignancies: non-small cell lung cancer, breast...
In the vertebrate retina, it has been shown that a large number of neurons produced at onset neurogenesis die early in development. Since this apoptotic cell death occurs short, limited time, little is known detail on its histocytology. Using terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) method, we investigated cells adult goldfish retina which progenitor keeps proliferating. Most TUNEL-positive nuclei were found marginal about 40–200 µm from circular blood...
Tumor genotyping using multiplex gene panel is now standard for precision medicine in non-small-cell lung carcinoma (NSCLC). We sought to assess the prevalence of actionable genomic alterations among NSCLC patients our next-generation sequencing (NCC Oncopanel) and response matched therapy. This a post-hoc analysis prospective study which with advanced solid cancer were prospectively enrolled undergo comprehensive profiling conducted between July 2013 March 2018 National Cancer Center...
8053 Background: Predicting the risk of postoperative recurrence is becoming increasingly important in patients (pts) with resectable EGFR mutation positive ( EGFRm) non-small cell lung cancer (NSCLC) after ADAURA trial. The presence non-solid ground-grass opacity (GGO) component on computed tomography (CT) images known to affect prognosis stage I cancer. Only a few reports investigating relationship between gene alterations and CT EGFRm NSCLC. Methods: We have developed machine...