A5100750880- Herpesvirus Infections and Treatments
- Virus-based gene therapy research
- Virology and Viral Diseases
- Cytomegalovirus and herpesvirus research
- Nematode management and characterization studies
- interferon and immune responses
- Viral-associated cancers and disorders
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Viral Infections and Vectors
- Immune cells in cancer
- Mosquito-borne diseases and control
- Inflammasome and immune disorders
- Oral microbiology and periodontitis research
- Software Engineering Research
- Plant Disease Resistance and Genetics
- Monoclonal and Polyclonal Antibodies Research
- Plant Pathogens and Resistance
- Gout, Hyperuricemia, Uric Acid
- Gut microbiota and health
- Cancer Research and Treatments
- Animal Virus Infections Studies
- Pregnancy-related medical research
- Malaria Research and Control
Third Affiliated Hospital of Sun Yat-sen University
2022-2024
Traffic Management Research Institute
2024
Sun Yat-sen University
2021-2024
Chinese Academy of Agricultural Sciences
2019-2024
Harbin Veterinary Research Institute
2019-2024
Renji Hospital
2022
Northeast Agricultural University
2019-2022
Tsinghua University
2022
Ruijin Hospital
2022
Shanghai Jiao Tong University
2022
Osteoporosis (OP) is a chronic metabolic bone disease characterized by diminished mass, decreased strength, deterioration of microarchitecture, and increased fragility with fracture risk. The aging population has made OP public health problem that serious effects on individuals, families, society as whole. It urgent new strategies are safe, effective, inexpensive for the treatment should be developed. Increasing evidence suggested gut microbiota (GM) inextricably linked to homeostasis...
Feedback from software users, such as bug reports, is vital in the management of projects. In GitHub, feedback typically expressed new issues. Through filing issue users may help identify and fix bugs, document code, enhance quality via feature requests. this paper, we aim at investigating some characteristics issues to facilitate management. We investigate important degrees behaviors that are related popular projects assess importance GitHub analyze effectiveness labeling for handling....
Abstract Background Parkinson’s disease (PD) is a progressive neurodegenerative with increasing prevalence. Effective diagnostic markers and therapeutic methods are still lacking. Exploring key molecular mechanisms for PD can help early diagnosis treatment improvement. Methods Three datasets GSE174052, GSE77668, GSE168496 were obtained from the GEO database to search differentially expressed circRNA (DECs), miRNAs (DEMis), mRNAs (DEMs). GO KEGG enrichment analyses, protein–protein...
Mosquito-borne flaviviruses include a group of pathogenic viruses that cause serious diseases in humans and animals, including dengue, West Nile, Japanese encephalitis viruses. These are zoonotic use birds, as amplifying reservoir hosts. Avian Tembusu virus (TMUV) is an emerging mosquito-borne flavivirus for many avian species can infect cells derived from mammals vitro . Although not currently primates, the infection duck industry workers potential risk TMUV immunocompromised individuals...
Peste des petits ruminants virus (PPRV) causes an acute and highly contagious disease of sheep goats has spread with alarming speed around the world. The pathology is linked to retrogressive changes necrotic lesions in lymphoid tissues epithelial cells. However, process PPRV entry into host cells remains largely unknown. Here, we performed a comprehensive study mechanism caprine endometrial (EECs). We clearly demonstrated that internalization was inhibited by chloroquine ammonium chloride,...
Air traffic is exhibiting the characteristics of high density, volume, and unmanned operations. To ensure smooth, efficient, safe, reliable operations, it necessary to promote digital transformation Traffic Management (ATM) with digitalization, autonomy, collaboration as its typical features. This article, based on background current foreseeable future ATM needs, deeply analyzes challenges opportunities faced by traditional ATM. It explores proposes further investigate commonalities,...
Although therapeutics targeting viral metabolic processes have been considered as promising strategies to treat herpesvirus infection, the requirements of gallid alphaherpesvirus 1 (ILTV), which is economically important poultry industry worldwide, remain largely unknown. Using ILTV-susceptible but nonpermissive chicken cell line DF-1 and ILTV-permissive LMH models, present study explored ILTV by global transcriptome analysis metabolome assays infected lines in combination with a set...
Gallid alpha-herpesvirus 1, also known as avian infectious laryngotracheitis virus (ILTV), continues to cause huge economic losses the poultry industry worldwide. Similar that of other herpesvirus-encoded proteins, expression viral genes encoded by ILTV is regulated a cascade, and underlying regulatory mechanism remains largely unclear. The immediate-early (IE) gene ICP4 plays prominent role in initiation transcription early late during replication. In this study, we identified AP-1 key...
Peste des petits ruminants virus (PPRV), the etiological agent of peste (PPR), causes an acute or subacute disease in small ruminants. Although abortion is observed unusually large proportion pregnant goats during outbreaks PPR, pathogenic mechanism underlying remains unclear. Here, gene expression profile caprine endometrial epithelial cells (EECs) infected with PPRV Nigeria 75/1 was determined by DNA microarray to investigate cellular response immediately after viral entry. The analysis...
Abstract Potato rot nematode Ditylenchus destructor is one of the most damaging pests in potato-producing regions and causes severe yield losses worldwide. However, D. has been rarely reported potato crops China. We collected 542 samples from 17 Chinese provinces during 2016–2020 for detection using species-specific primers universal targeting ribosomal internal transcribed spacer (ITS) or 28S RNA (rRNA) sequences. was detected 14.94% total samples, primarily Inner Mongolia Autonomous Region...
P53, a well-known tumor suppressor, has been confirmed to regulate the infection of various viruses, including chicken viruses. Our previous study observed antiviral effect p53 inhibitor Pifithrin-α (PFT-α) on avian infectious laryngotracheitis virus (ILTV), one major viruses economically significant poultry industry globally. However, potential link between this PFT-α and remains unclear. Using LMH cell line which is permissive for ILTV as model, we explore effects replication its...
The tumor suppressor p53, which acts primarily as a transcription factor, can regulate infections from various viruses in chickens. However, the underlying mechanisms of antiviral functions chicken p53 (chp53) remain unclear due to lack detailed information on its transcriptional regulation. Here, gain comprehensive insights into chp53 regulatory function global and unbiased manner, we determined genome-wide chromatin occupancy by immunoprecipitation, was followed sequencing chp53-mediated...
ABSTRACT The tumor suppressor p53, primarily functioning as a transcription factor, has exhibited antiviral capabilities against various viruses in chickens, including infectious bursal disease virus (IBDV), avian leukosis subgroup J (ALV-J), and laryngotracheitis (ILTV). Nevertheless, the existence of universal mechanism employed by chicken p53 (chp53) these remains uncertain. This study conducted comprehensive comparison molecular networks involved chp53’s function IBDV, ALV-J, ILTV. was...
Abstract Lumbar cerebrospinal fluid (CSF) parameters are widely studied and have wide clinical applications, but ventricular CSF has rarely been since it is relatively difficult to obtain. To determine whether there differences between lumbar the significance, we retrospectively reviewed 77 patients with Cryptococcal meningitis who received a ventriculoperitoneal shunt. We analyzed following parameters: white blood cell count, total protein concentration, CSF/blood glucose ratio, chloride...
Aspartokinase (AK) is synergistically suppressed by Thr and Lys in the Corynebacterium metabolic pathway. Site-directed mutations can significantly improve AK inhibition. Here, a double mutant, T379L/A380M, with improved enzyme activity (2.74-fold) was obtained, based on prior screening. Enzymatic property experiments showed that optimum temperature of T379L/A380M increased from 26°C (recombinant Escherichia coli ; WT-AK) to 45°C optimal pH decreased 8.0 (WT-AK) 7.5. Further, half-life 4.5...