A5069956437- Folate and B Vitamins Research
- Advanced Radiotherapy Techniques
- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Digestive system and related health
- Medical Imaging Techniques and Applications
- Cancer Research and Treatments
- MRI in cancer diagnosis
- Radiation Therapy and Dosimetry
- Lung Cancer Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Bladder and Urothelial Cancer Treatments
- Cancer, Hypoxia, and Metabolism
- Sulfur Compounds in Biology
- Breast Lesions and Carcinomas
- Cancer survivorship and care
- Metabolomics and Mass Spectrometry Studies
- Inflammatory Biomarkers in Disease Prognosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Brain Metastases and Treatment
- Management of metastatic bone disease
- Esophageal and GI Pathology
- Tumors and Oncological Cases
- Advances in Oncology and Radiotherapy
- Infectious Diseases and Mycology
Siemens Healthcare (United States)
2023
Northwestern University
2021-2023
Northwestern Medicine
2022
Northwestern Memorial Hospital
2022
The University of Texas MD Anderson Cancer Center
2019-2021
The University of Texas Medical Branch at Galveston
2017-2020
Abstract The trans-sulfuration enzyme cystathionine-β-synthase (CBS) and its product hydrogen sulfide (H2S) are aberrantly upregulated in colorectal cancers, where they contribute to tumor growth progression by both autocrine paracrine mechanisms. However, it is unknown whether the CBS/H2S axis plays a role carcinogenesis. Here, we report upregulation of CBS human biopsies precancerous adenomatous polyps show that forced an adenoma-like colonic epithelial cell line sufficient induce...
Glioblastoma is an aggressive brain tumor with a propensity for intracranial recurrence. We hypothesized that tumors can be visualized diffusion tensor imaging (DTI) before they are detected on anatomical magnetic resonance (MR) images. retrospectively analyzed serial MR images from 30 patients, including the DTI and T1-weighted at recurrence, 2 months 4 1 month after radiation therapy. The maps T1 were deformably registered longitudinally. recurrent was manually segmented image then applied...
PURPOSE We developed a deep neural network that queries the lung computed tomography–derived feature space to identify radiation sensitivity parameters can predict treatment failures and hence guide individualization of radiotherapy dose. In this article, we examine transportability model across health systems. METHODS This multicenter cohort-based registry included 1,120 patients with cancer in treated stereotactic body radiotherapy. Pretherapy tomography images from internal study cohort...
Deep learning (DL) models that use medical images to predict clinical outcomes are poised for translation. For tumors reside in organs move, however, the impact of motion (i.e., degenerated object appearance or blur) on DL model accuracy remains unclear. We examine tumor an image-based framework predicts local failure risk after lung stereotactic body radiotherapy (SBRT).We input pre-therapy free breathing (FB) computed tomography (CT) from 849 patients treated with SBRT into a multitask...
Screening mammography has helped to identify countless incidences of breast cancer since its adoption in the 1960s. Over time, screening guidelines and techniques have been refined better detect malignancies avoid false positive results. However, weaknesses remain represent an opportunity for improvement. The interference natural tissue glands can obscure presence occult malignancies. Additionally, inability differentiate on basis depth, compounding densities that occurs as a consequence...
This secondary image analysis of a randomized trial proton radiotherapy (PT) versus photon intensity-modulated (IMRT) compares tumor progression based on clinical radiological assessment Response Assessment in Neuro-Oncology (RANO).Eligible patients were enrolled the and had MR imaging at baseline follow-up beyond 12 weeks from completion radiotherapy. "Clinical progression" was radiology report and/or change treatment for progression.Of 90 patients, 66 evaluable. Median progression-free...
<div>Abstract<p>The trans-sulfuration enzyme cystathionine-β-synthase (CBS) and its product hydrogen sulfide (H2S) are aberrantly upregulated in colorectal cancers, where they contribute to tumor growth progression by both autocrine paracrine mechanisms. However, it is unknown whether the CBS/H2S axis plays a role carcinogenesis. Here, we report upregulation of CBS human biopsies precancerous adenomatous polyps show that forced an adenoma-like colonic epithelial cell line...
<p>Effect of buthionine-sulfoximine (BSO) on growth CBS2 and vector control cells.</p>
<p>CBS overexpression and an H2S donor (GYY4137) enhanced NCM356 cell growth in soft agar.</p>
<p>Gene Set Enrichment Analysis for NCM356 vector vs. CBS cells.</p>
<p>Cysteine metabolites in NCM356 CBS cells.</p>
<p>Comparison of metabolite levels in CBS2 vs. vector control NCM356 cells.</p>
<p>Additional description of metabolic effects and hydrogen sulfide on CBS overexpression in NCM356 cells.</p>
<p>Single-nucleotide polymorphism analysis for NCM356 cells.</p>
<p>Gene Set Enrichment Analysis for NCM356 vector vs. CBS cells.</p>
<p>CBS overexpression and an H2S donor (GYY4137) enhanced NCM356 cell growth in soft agar.</p>
<p>Effect of buthionine-sulfoximine (BSO) on growth CBS2 and vector control cells.</p>
<p>Comparison of metabolite levels in CBS2 vs. vector control NCM356 cells.</p>
<p>Cysteine metabolites in NCM356 CBS cells.</p>