A5053641673- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Animal Behavior and Welfare Studies
- Genetic and phenotypic traits in livestock
- Reproductive Physiology in Livestock
- Milk Quality and Mastitis in Dairy Cows
- Effects of Environmental Stressors on Livestock
- Retinal and Optic Conditions
- Veterinary Practice and Education Studies
- Animal Disease Management and Epidemiology
- Ruminant Nutrition and Digestive Physiology
- Optical Imaging and Spectroscopy Techniques
- Pharmaceutical and Antibiotic Environmental Impacts
- Veterinary Pharmacology and Anesthesia
- Microbial infections and disease research
- Veterinary Equine Medical Research
- Agriculture and Farm Safety
- Animal health and immunology
- Probiotics and Fermented Foods
- Traumatic Brain Injury and Neurovascular Disturbances
- Retinal Development and Disorders
- Neurological Disorders and Treatments
- Antibiotic Resistance in Bacteria
- Clinical practice guidelines implementation
University of Waterloo
2011-2024
University of Nottingham
2015-2024
Loughborough University
2022-2024
Community Health Alliance
2024
Western University
2022-2023
London Health Sciences Centre
2023
Sunnybrook Health Science Centre
2021-2022
University of Bristol
2006-2022
Cardiff University
2022
Centre Île-de-France - Versailles-Grignon
2022
Abstract Auxin plays a fundamental role in organogenesis plants. Multiple pathways for auxin biosynthesis have been proposed, but none of the predicted are completely understood. Here, we report positional cloning and characterization vanishing tassel2 (vt2) gene maize (Zea mays). Phylogenetic analyses indicate that vt2 is co-ortholog TRYPTOPHAN AMINOTRANSFERASE OF ARABIDOPSIS1 (TAA1), which converts Trp to indole-3-pyruvic acid one four hypothesized Trp-dependent pathways. Unlike single...
Abstract Because individuals develop dementia as a manifestation of neurodegenerative or neurovascular disorder, there is need to reliable approaches their identification. We are undertaking an observational study (Ontario Neurodegenerative Disease Research Initiative [ONDRI]) that includes genomics, neuroimaging, and assessments cognition well language, speech, gait, retinal imaging, eye tracking. Disorders studied include Alzheimer’s disease, amyotrophic lateral sclerosis, frontotemporal...
The objective of this research was to evaluate the relationship between udder health and reproductive performance in UK dairy cows. Data from 80 herds were restructured such that each unit data represented a 2-d period during lactation where cow at risk becoming pregnant. Multilevel discrete-time survival models then used within Bayesian framework explore associations outcomes variety potential explanatory variables. Separate constructed using 2 different univariate binary outcomes: pregnant...
Antimicrobial resistance has been reported to represent a growing threat both human and animal health, concerns have raised around levels of antimicrobial usage (AMU) within the livestock industry. To provide benchmark for dairy cattle AMU identify factors associated with high AMU, data from convenience sample 358 farms were analysed using mass‐based dose‐based metrics following standard methodologies proposed by European Surveillance Veterinary Consumption project. Metrics calculated mass...
Abstract Mastitis in dairy cattle is extremely costly both economic and welfare terms one of the most significant drivers antimicrobial usage cattle. A critical step prevention mastitis diagnosis predominant route transmission pathogens into either contagious (CONT) or environmental (ENV), with being further subdivided as during nonlactating “dry” period (EDP) lactating (EL). Using data from 1000 farms, random forest algorithms were able to replicate complex herd level diagnoses made by...
Abstract Oculomotor tasks generate a potential wealth of behavioural biomarkers for neurodegenerative diseases. Overlap between oculomotor and disease-impaired circuitry reveals the location severity disease processes via saccade parameters measured from eye movement such as prosaccade antisaccade. Existing studies typically examine few in single diseases, using multiple separate neuropsychological test scores to relate behaviour cognition; however, this approach produces inconsistent,...
ATTITUDES towards pain and its control in farm animals have lagged behind those companion animal species. However, a considerable amount of work over the past 15 years has focused on perception cattle based objective subjective assessment by clinicians working with this A recent large‐scale survey practitioners revealed that half respondents felt their knowledge analgesia was inadequate or could be improved, majority these identified lack readily available information subject as being...
Antibiotic resistance is one of the most serious public health risks facing humanity. The overuse antibiotics in treatment infectious disease have been identified as sources global threat antibiotic resistance. This paper examines how farmers perceive and manage associated with antibiotics. Specifically, role habitus risk determining farmers' decisions to adopt national reduction targets set by members Responsible Use Medicines Agriculture Alliance's Targets Task Force. Semi-structured...
The objective of this study was to establish the baseline retinal hemodynamic characteristics stratified groups diabetic patients at increasing risk for development macular edema (DME). Group 1 had 50 control subjects, group 2 56 without clinically visible retinopathy, 3 54 with microaneurysms and/or hard exudates within two disc diameters fovea in absence manifest DME, and 4 40 DME. Retinal hemodynamics (diameter, velocity, maximum-to-minimum velocity ratio, flow) were assessed. Intraocular...
The aim of this research was to use probabilistic sensitivity analysis evaluate the relative importance different components a model designed estimate cost clinical mastitis (CM). A particular focus placed on pathogen transmission other factors, such as milk price or treatment costs. stochastic Monte Carlo developed simulate case CM at cow level and calculate associated costs for 5 defined protocols. protocols modeled were 3 d antibiotic intramammary treatment, systemic 3d plus 1...
Key points Vascular reactivity, the response of vessels to a vasoactive stimulus such as hypoxia and hyperoxia, can be used assess vascular range adjustment in which are able compensate for changes . Previous studies retina have not accurately quantified retinal responses precisely targeted multiple stimuli at same time controlling level carbon dioxide, thus precluding them from modelling relationship between blood flow oxygen. The present study modelled , showing combined linear hyperbolic...
Chronic Lymphocytic Leukaemia (CLL) is associated with immune suppression and susceptibility to infection. CD8+ T cell numbers are increased demonstrate elevated expression of PD-1 impaired function. The mechanisms driving these features exhaustion uncertain but likely include chronic recognition tumor and/or infectious agents. We investigated the number, phenotype function total virus-specific cells in 65 patients CLL 14 undergoing long-term ibrutinib therapy (median 21 months). Ibrutinib...
The aim of this study was to simultaneously quantify the magnitude and response characteristics retinal arteriolar diameter blood velocity induced by an isocapnic hyperoxic provocation in a group clinically normal subjects. sample comprised 10 subjects (mean age, 25 yr; range, 21-40 yr). Subjects initially breathed air for 5-10 min, then O(2) 20 final 10-min period via sequential rebreathing circuit (Hi-Ox; Viasys) maintain isocapnia. Retinal measurements were acquired with Canon laser...
To quantify the magnitude of retinal arteriolar vascular reactivity in diabetic patients stratified by severity retinopathy and age-matched control subjects. The sample comprised 21 nondiabetic subjects (group 1), 19 with no clinically visible DR 2), mild-to-moderate nonproliferative without evident macular edema (DME) 3), 17 DME 4). methods Subjects initially breathed air, followed oxygen, while isocapnia was maintained. Retinal diameter blood velocity measurements were acquired...
The p53 family member p63 has been shown to be critical for growth, proliferation and chemosensitivity. Here we demonstrate that the c-Abl tyrosine kinase phosphorylates widely expressed ΔNp63α isoform identify multiple sites by mass spectrometry in vitro vivo. Phopshorylation results greater protein stability of both ectopically endogenous ΔNp63α. phosphorylation induces its binding Yes-associated (YAP) silencing YAP siRNA reduces c-Abl-induced increase levels. We further show cisplatin...
An understanding of the normal estrous-cycle length cow is important when managing and monitoring dairy-herd fertility. Although interovulatory interval widely considered to be 21 d, some studies have found alternative intervals more prevalent; previously, most variation in was expected between cows. The aim this study assess time inseminations (interservice interval, ISI) a large number dairy cows explore possible associations factors length. used ISI data from 42,252 159 herds across...
The impact of anaemia on patients undergoing aortic valve surgery has not been well studied. We sought to evaluate the effect early outcomes following replacement (AVR).All non-emergent (n = 2698) with or without other concomitant procedures between 1997 and 2010 were included. Preoperative was defined as per World Health Organization guidelines haemoglobin (Hb) < 130 g/l in men Hb 120 women. Multivariable analyses used determine association preoperative postoperative outcomes.The prevalence...
Foot trimming is a common management intervention in prevention of lameness dairy cattle. Despite this, there surprisingly limited experimental evidence on its efficacy, especially regard to primiparous heifers. A randomised, negatively controlled trial was conducted investigate the association between an early lactation foot trim animals and production outcomes. 282 heifers were enrolled from eight farms UK, randomly assigned treatment or control groups. Milk yield (305‐day‐adjusted...