A5102820249- Ferroptosis and cancer prognosis
- Renal and related cancers
- Renal cell carcinoma treatment
- Mathematical Biology Tumor Growth
- Renal function and acid-base balance
- Renal Transplantation Outcomes and Treatments
- Cancer Cells and Metastasis
- Immune cells in cancer
- Cell Image Analysis Techniques
- Single-cell and spatial transcriptomics
- GDF15 and Related Biomarkers
- Gastrointestinal Tumor Research and Treatment
- Biliary and Gastrointestinal Fistulas
- Glioma Diagnosis and Treatment
- Cellular Mechanics and Interactions
- MicroRNA in disease regulation
- Chronic Kidney Disease and Diabetes
- Gastrointestinal disorders and treatments
- Metabolomics and Mass Spectrometry Studies
Qilu Hospital of Shandong University
2022-2025
Tongji Hospital
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Huazhong University of Science and Technology
2022-2024
Shandong University
2022
Ministry of Education of the People's Republic of China
2022
Saudi Center for Organ Transplantation
2022
Detection Limit (United States)
2022
First Hospital of Jilin University
2020
Jilin University
2020
Abstract Background Glioblastoma (GBM) is largely refractory to antibodies against programmed cell death 1 (anti‐PD‐1) therapy. Fully understanding the cellular heterogeneity and immune adaptations in response anti‐PD‐1 therapy necessary design more effective immunotherapies for GBM. This study aimed dissect molecular mechanisms of specific immunosuppressive subpopulations drive resistance Methods We systematically analysed single‐cell RNA sequencing spatial transcriptomics data from GBM...
Background Glioblastoma (GBM) is a fatal brain tumor with no effective treatment. The specific GBM immune microenvironment (TIME) may contribute to resistance immunotherapy, therapy great potential. Thus, an in-depth understanding of the characteristics tumor-infiltrating cells essential for exploring biomarkers in pathogenesis and immunotherapy. Methods We estimated relative abundances 25 cell types 796 samples using single sample gene set enrichment analysis (ssGSEA). Unsupervised...
Abstract Background Thymosin family genes (TMSs), biologically important peptides with diverse intracellular and extracellular functions, have been shown to promote the progression of multiple cancers. However, multiomics characterization TMSs their role in human cancer prognosis has not systematically performed. Methods We performed a comprehensive analysis thymosin β10 (TMSB10) using data from more than 10,000 tumor samples 33 types The Cancer Genome Atlas (TCGA). used single-sample gene...
Renal ischemia-reperfusion injury (RIRI) plays an important role in the poor prognosis of patients with renal transplants. However, potential targets and mechanism IRI are still unclear. Differential gene expression (DEG) analysis weighted correlation network (WGCNA) were performed on GSE27274 dataset. Pathway enrichment DEGs was performed. To identify hub DEGs, we constructed a protein-protein interaction (PPI) network. Finally, genes verified, candidate drugs screened from DsigDB database....
The duodenal intussusception is rarely reported and usually occurs secondary to organic diseases of the duodenum such as polyps, tumors duplication cysts. Herein we report a case caused by diverticulum.A 21-year old male patient presented with abdominal pain vomiting for one day. A contrast enhanced computed tomography abdomen revealed intussusception. On emergency laparotomy, had reduced spontaneously while an invaginated diverticulum was seen at junction descending horizontal segments...
Clear cell renal carcinoma (ccRCC) is an immunogenic tumor, and investigating the immunorelated genes essential. To investigate immunoprognostic of ccRCC, we analyzed data assimilated from a public database (The Cancer Genome Atlas (TCGA) gene expression omnibus (GEO) database) using bioinformatics. Then, immunoprognosis model was constructed to identify four hub with moderate predictive values for prognosis ccRCC patients. These were associated patients based on Oncomine Gena Expression...
Abstract Clear cell renal carcinoma (ccRCC) is an immunogenic tumor and investigating the immunorelated genes of great significance. To investigate immunoprognostic ccRCC, we analyzed data assimilated from a public database (The Cancer Genome Atlas (TCGA) gene expression omnibus (GEO) database) using bioinformatics. Then, immunoprognosis model was constructed to identify 4 hub with moderate predictive values for prognosis ccRCC patients. Interestingly, these were associated patients based on...