A5057978103- Trace Elements in Health
- Ion Transport and Channel Regulation
- Helicobacter pylori-related gastroenterology studies
- Cardiac, Anesthesia and Surgical Outcomes
- Hernia repair and management
- Child Nutrition and Water Access
- Ion channel regulation and function
- Clinical Nutrition and Gastroenterology
- Gastroesophageal reflux and treatments
- Colorectal Cancer Surgical Treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Neurobiology and Insect Physiology Research
- Gallbladder and Bile Duct Disorders
- Magnesium in Health and Disease
- Appendicitis Diagnosis and Management
- Drug Transport and Resistance Mechanisms
- Intestinal and Peritoneal Adhesions
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal motility and disorders
- Heavy Metal Exposure and Toxicity
- Surgical Simulation and Training
- Biliary and Gastrointestinal Fistulas
- Iron Metabolism and Disorders
- Esophageal and GI Pathology
- Potassium and Related Disorders
Dartmouth–Hitchcock Medical Center
2024
White River Junction VA Medical Center
2020-2024
Dartmouth College
2021-2024
Malcom Randall VA Medical Center
2023
Penn State Milton S. Hershey Medical Center
2012-2021
Pennsylvania State University
2012-2020
American College of Surgeons
2018
Hershey (United States)
2015-2018
Brigham and Women's Hospital
2004-2017
Harvard University
1999-2014
Objective To examine, in the Veterans Health Administration (VHA), relation between surgical volume and outcome eight commonly performed operations of intermediate complexity. Summary Background Data In multihospital health care systems such as VHA, consideration is often given to closing low-volume services, with assumption that better outcomes are achieved hospitals larger volumes. Literature data support this intermediate-complexity either limited or controversial. Methods The VHA...
The extracellular calcium ([Formula: see text])-sensing receptor (CaR) plays vital roles in [Formula: text] homeostasis, but no data are available on its expression small and large intestine. Polymerase chain reaction products amplified from reverse-transcribed duodenal RNA using CaR-specific primers showed >99% homology with the rat kidney CaR. Northern analysis a cRNA probe demonstrated 4.1- 7.5-kb transcripts all intestinal segments. Immunohistochemistry antisera clear basal staining...
Zinc (Zn) hyper-accumulates in breast tumors and malignant cell lines compared to normal mammary epithelium. The mechanisms responsible for Zn accumulation the consequence of dysregulation are poorly understood. Microarrays were performed assess differences expression transporters metallothioneins (MTs) human cancer lines. Real-time PCR immunoblotting employed profile transporter representative luminal (T47D), basal (MDA-MB-231), non-malignant (MCF10A) distribution was assessed by X-ray...
<h3>Importance</h3> In trauma populations, improvements in outcome are documented institutions with higher case volumes. However, it is not known whether improved outcomes attributable to the volume within specific higher-risk groups, such as elderly, or among all patients treated by an institution. <h3>Objective</h3> To test hypothesis that of care for geriatric affected differently cases and nongeriatric <h3>Design, Setting, Participants</h3> This retrospective cohort study using a...
The extracellular calcium (Ca2+o)-sensing receptor (CaR) plays a critical role in maintaining Ca2+o homeostasis mammals by virtue of its presence parathyroid gland and kidney. breast is well recognized as Ca2+-handling organ, the effects altering on proliferation epithelial cells are documented. To date there no data regarding expression localization CaR tissue. In present study, we assessed distribution messenger ribonucleic acid (mRNA) protein normal fibrocystic human tissue ductal...
Mammary gland involution is the most dramatic example of physiological cell death. It occurs through an initial phase lysosomal-mediated death (LCD) followed by mitochondrial-mediated apoptosis. Zinc (Zn) activates both LCD and apoptosis in vitro. The Zn transporter ZnT2 imports into vesicles mitochondria ZnT2-overexpression mammary epithelial cells (MECs). We tested hypothesis that ZnT2-mediated transport critical for mice. Following weaning, abundance increased lysosomes mitochondria,...
Patients with medically complex conditions undergoing repair of large or recurrent hernia the abdominal wall are at risk for early postoperative hyperglycemia, which may serve as an warning delays in recovery and adverse outcomes.To evaluate serum glucose level a predictor outcome after open ventral patients major medical comorbidities.We performed retrospective record review 172 consecutive who underwent Penn State Milton S. Hershey Medical Center, academic tertiary referral center, from...
Scope Greater than 68% of young infants are exposed to dietary zinc (Zn) levels that higher the Tolerable Upper Intake Limit. However, consequences excess Zn during early life on intestinal function and host–microbe interactions unknown. Methods Results Neonatal mice gavaged with 100 µg d –1 from postnatal day (PN) 2 through PN10 indices compared unsupplemented mice. Excess causes oxidative stress, increases goblet cell number mucus production, associated increased permeability systemic...
The records of 18 cirrhotic patients with ascites and groin hernias (20 inguinal one femoral) were retrospectively reviewed. Eleven underwent repair their (total 13 repairs). Ten herniorrhaphies performed electively, two urgently because recent difficult reduction, was emergently for incarceration without strangulation. No major four minor postoperative complications occurred. There no perioperative deaths or leaks. Of the in 11 undergoing repair, 12 (92%) available follow-up. In this group,...