A5084522813- Cardiovascular Health and Risk Factors
- Cardiovascular Function and Risk Factors
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Blood Pressure and Hypertension Studies
- Nail Diseases and Treatments
- Heart Failure Treatment and Management
- Cardiovascular Syncope and Autonomic Disorders
- Lipoproteins and Cardiovascular Health
- Parathyroid Disorders and Treatments
- Eosinophilic Disorders and Syndromes
- Global Health Workforce Issues
- Diversity and Career in Medicine
- Health and Lifestyle Studies
- Nutritional Studies and Diet
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Disease and Adiposity
- Cardiac pacing and defibrillation studies
- Peripheral Artery Disease Management
Albert Einstein College of Medicine
2023-2025
Rutgers, The State University of New Jersey
2024
Northwell Health
2024
Jackson Memorial Hospital
2024
St. Barnabas Hospital
2024
Montefiore Medical Center
2024
Yeshiva University
2023
Cardiovascular Research Center
2023
University of Miami
2023
BACKGROUND: Lp(a) (lipoprotein[a]) is a risk factor for cardiovascular disease; however, its association with cerebrovascular disease not as well established. METHODS: Data from population-based cohort of Hispanics/Latinos included 16 333 individuals baseline levels (nmol/L) and self-reported prevalent stroke or transient ischemic attack (TIA). A subset 2642 brain magnetic resonance imaging was also included. Linear multivariate logistic regression assessed the (1) TIA, (2) cerebral injury...
Thrombotic and bleeding complications are major causes of morbidity mortality in patients with polycythemia vera, who predominantly present an alteration the JAK2 gene. Because their hypercoagulable state risk hemorrhage, vera acute myocardial infarction pose a challenge to physicians. This case report describes presentation treatment Hispanic patient V617F-negative primary developed cardiac arrest ST-segment elevation owing complete occlusion left anterior descending artery as well...
Introduction: Lipoprotein(a) [Lp(a)] is a known risk factor for cardiovascular disease; however, its association with cerebrovascular disease not as well established. Methods: Data from HCHS/SOL, population-based cohort of Hispanics/Latinos, was utilized. We included 16,039 participants measured Lp(a) levels (nmol/L) and self-reported history prevalent stroke or transient-ischemic attack (TIA) Visit 1. SOL-INCA MRI (ancillary study conducted after 2) utilized to identify subset 2,668...
During the assessment of a third-degree atrioventricular (AV) block in patient with syncope, different etiologies should be considered and evaluated. Extrinsic vagal paroxysmal AV block, extrinsic idiopathic intrinsic are among types differential diagnoses. (EV-AVB) is linked to parasympathetic influence on cardiac conduction can observed bladder distention urinary retention. Topical ophthalmic beta-blockers have shown systemic effects such as bradycardia without syncope. We present case an...
Hispanics/Latinos of Dominican background living in United States (US) have the highest hypertension prevalence compared with other Hispanic/Latino persons.
Background: Hispanics are a highly admixed population. Pooled Cohort Equation (PCE) excluded them in its derivation. We analyzed Hispanic background and genetic ancestry relation to atherosclerotic cardiovascular disease (ASCVD) risk. Methods: included 966 from Multi-Ethnic Study of Atherosclerosis (MESA), aged 44-75 years free diabetes/prior CVD. Statin users those with LDL-C>190 mg/dL were excluded. Continental (West African [AA], European [EA]) was estimated by ADMIXTURE software....
Background: Current recommendations include using the non-Hispanic White (NHW) pooled cohort equation (PCE) for 10-year atherosclerotic cardiovascular disease (ASCVD) risk estimation among Hispanic individuals and Black (NHB) PCE when African ancestry is present. We studied performance at thresholds of European US Hispanics. Methods: participants from Multi-Ethnic Study Atherosclerosis (MESA), ages 44-75 years without diabetes mellitus or prior were included. ADMIXTURE software was used to...
Background: Impaired kidney function is an independent risk factor for heart failure (HF), but its association with pre-HF not as well studied. We assessed in relation to a diverse Hispanic/Latino population the US. Methods: Echocardiographic data from visit (V) 1 and 2 of Echo-SOL were analyzed (unweighted n=1643). Prevalent was defined any abnormal echocardiographic parameter at V1: left ventricular (LV) systolic dysfunction (LVSD) [ejection fraction <50%, global longitudinal strain...
Background: Transthyretin amyloidosis, most often caused by Val122Ile mutation, is linked to a higher risk of heart failure (HF) and mortality. Subclinical abnormalities in cardiac structure function mutations are less well defined Hispanics/Latinos. We studied the phenotype Hispanic/Latino carriers versus non-carriers. Methods: carrier status was determined with genome-wide data. analyzed echocardiographic data from adults 45 years or older (unweighted n= 6376) HCHS/SOL Echocardiographic...
Background: Val122Ile variant is the most common mutation causing hereditary transthyretin amyloidosis. The prevalence of among Hispanics/Latinos, a population with admixed genetic ancestry (African, European, Amerindian), still unknown. Methods: We utilized genome-wide data (unweighted n=12687 adults) from population-based HCHS/SOL to identify mutation. Continental proportions African (AA), European (EA) and Amerindian (AM) were computed an ADMIXTURE software, thresholds set at 30%, 40%,...
Introduction: The role of the right ventricle (RV) in influencing clinical outcomes and overall survival is well established. However,RV serial change over time influence sociodemographic factors on RV structure/function remains understudied, especially among Hispanics/Latinos. Methods: ECHO-SOL comprehensively assessed structure function Hispanic/Latino 1643 adults at baseline (visit 1 2011-2014) 4.3 years later 2 2015-2019). functional parameters included were peak S’ velocity (PsV),...
Introduction: Hispanic/Latino individuals are known to have higher traditional cardiovascular disease (CVD) risk factors compared non-Hispanic Whites and Asians. However, inconsistencies variability exist regarding the incidence of heart failure (HF) among Hispanics other race/ethnic groups. We examined HF in participants enrolled Hispanic Community Health Study/Study Latinos (HCHS/SOL). Methods: The baseline HCHS/SOL population consisted 16,415 between 2008 - 2011 followed up for incident...
Introduction: Among non-Hispanics, hypertension (HTN) disparities by self-reported race exist. Hispanics/Latinos (H/L) are an admixed population of African (AA), European (EA) and Amerindian (AI) continental genetic ancestry (GA). Few studies have explored HTN among H/L. We assessed, H/L, the associations with GA, GA HTN. Methods: Data was obtained from HCHS/SOL, a population-based cohort United States (US) included mutually unrelated subjects ≥18 years old genotyping data. Proportions...
Introduction: Right ventricle (RV) changes secondary to severe lung disease are well described, but the association of pulmonary function tests (PFTs) and subclinical airflow obstruction with RV is unexplored. Methods: Serial echocardiograms conducted 4.3 years apart on 1643 adults (mean age 56.4 years, 41.5% female) during ECHO-SOL visits 1 (2011-2014) 2 (2015-2018) were analyzed. baseline change over time (from visit 2) assessed by echocardiographic outcomes: fractional area (RVFAC, %),...
Non-neoformans Cryptococcus species were formerly considered to be saprophytes and nonpathogenic humans [1-2]. However, the incidence of laurentii infections in immunocompromised immunocompetent patients has been gradually increasing over last decades During COVID-19 pandemic, multiple cases opportunistic bacterial fungal have reported after a severe SARS-CoV-2 infection. The author reports first case pulmonary cryptococcosis caused by severely ill patient who received treatment with...
Non-neoformans Cryptococcus species were formerly considered to be saprophytes and nonpathogenic humans. However, the incidence of laurentii infections in immunocompromised immunocompetent patients has been gradually increasing over last decades. During COVID-19 pandemic, multiple cases opportunistic bacterial fungal have reported after a severe SARS-CoV-2 infection. The author reports first case pulmonary cryptococcosis caused by severely ill patient who received treatment with Tocilizumab...
Introduction: Hypertension (HTN) is a modifiable risk factor for heart failure (HF) and common antecedent pre-HF, but its effect on pre-HF not well known. Hypothesis: Variations in blood pressure (BP) will be related to distinct patterns of (prevalent incident). Methods: Two echocardiograms were performed ∼4.3 years apart 1643 adults the Hispanic/Latino cohort ECHO SOL. Pre-HF was defined as systolic dysfunction (LVEF <50%/ global longitudinal strain >15%) or diastolic (≥ Grade 1) left...
Background: Hispanics/Latinos of Dominican background (HLDB) living in United States (US) have the highest hypertension prevalence compared with other Hispanic/Latino persons. To understand cardiovascular health among Dominicans, we evaluated and risk factors Dominicans from US Republic (DR) – using data Hispanic Community Health Study/ Study Latinos [HCHS/SOL] (n=1,473, Dominicans) ENPREFAR-HAS 17 (n=2,015 DR Dominicans).Methods: Hypertension was defined as blood pressure ≥140/90 mmHg,...
BACKGROUND: Diabetes Mellitus (DM) is an independent risk factor for heart failure (HF), yet research on the association of glucose homeostasis with pre-HF limited. We assessed longitudinally in relation to prevalent and incident Echocardiographic Study Latinos, Echo-SOL. Methods: Serial echocardiograms from 1595 adults (mean age 56.4 years), 61% female, Echo SOL were analyzed average 4.3 years apart. Prevalent was defined as presence one following parameters: LVEF <50%, global...