A5102656607- Pharmacogenetics and Drug Metabolism
- Computational Drug Discovery Methods
- Cardiovascular Health and Risk Factors
- Streptococcal Infections and Treatments
- Cancer Treatment and Pharmacology
- Antimicrobial Resistance in Staphylococcus
- Cancer therapeutics and mechanisms
- Pneumonia and Respiratory Infections
- Hypothalamic control of reproductive hormones
- Antibiotics Pharmacokinetics and Efficacy
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Mosquito-borne diseases and control
- Epigenetics and DNA Methylation
- Multiple Myeloma Research and Treatments
- Pharmaceutical studies and practices
- Protein Structure and Dynamics
- Heart Failure Treatment and Management
- TGF-β signaling in diseases
- Malaria Research and Control
- Analytical Methods in Pharmaceuticals
- Genetics, Bioinformatics, and Biomedical Research
- Plant Disease Resistance and Genetics
- Extracellular vesicles in disease
- Molecular Biology Techniques and Applications
Southern Medical University
2018-2024
Boai Hospital of Zhongshan
2024
Shanghai Jiao Tong University
2022-2024
Albert Einstein College of Medicine
2024
University College London
2024
Shanghai Children's Medical Center
2021-2024
Fudan University
2020-2023
China Pharmaceutical University
2016
Pharmacokinetic characterization plays a vital role in drug discovery and development. Although involving numerous laboratory animals with error-prone, labor-intensive, time-consuming procedures, pharmacokinetic profiling is still irreplaceable preclinical studies. With physiologically based (PBPK) modeling, the vivo profiles of absorption, distribution, metabolism, excretion can be predicted. To evaluate application such an approach investigations, plasma seven commonly used probe...
MiR-664 has been demonstrated to play an important role in dermal diseases. However, the functions of miR-664 ultraviolet B (UVB) radiation-induced keratinocytes damage remain be elucidated.The present study aimed investigate molecular mechanisms under UVB-induced and provide translational insights for future therapeutics UVB protection.HaCaT cells were transfected with miR-664, either alone or combined irradiation. Levels messenger RNA protein tested by quantitative real-time polymerase...
Vincristine (VCR) can cause vincristine‐induced peripheral neuropathy (VIPN) during the treatment of acute lymphoblastic leukemia (ALL) and mechanisms are complicated. The aim this study was to investigate influencing factors on population pharmacokinetics (PopPK) pharmacodynamics (PD) related VIPN, including clearance routes, drug–drug interactions (DDI), genetic characteristics. Pediatric patients being treated for ALL were recruited PK where VCR its metabolite (M1) measured using a novel...
<title>Abstract</title> Background Vancomycin trough concentration is closely associated with clinical efficacy and toxicity. Predicting vancomycin concentrations in pediatric patients challenging due to significant interindividual variability rapid physiological changes during maturation. Aim This study aimed develop a machine-learning (ML) model predict determine optimal dosing regimens using various algorithms. Method A single-center retrospective observational was conducted from January...
Background: Impaired kidney function is an independent risk factor for heart failure (HF), but its association with pre-HF not as well studied. We assessed in relation to a diverse Hispanic/Latino population the US. Methods: Echocardiographic data from visit (V) 1 and 2 of Echo-SOL were analyzed (unweighted n=1643). Prevalent was defined any abnormal echocardiographic parameter at V1: left ventricular (LV) systolic dysfunction (LVSD) [ejection fraction <50%, global longitudinal strain...
Introduction: The role of the right ventricle (RV) in influencing clinical outcomes and overall survival is well established. However,RV serial change over time influence sociodemographic factors on RV structure/function remains understudied, especially among Hispanics/Latinos. Methods: ECHO-SOL comprehensively assessed structure function Hispanic/Latino 1643 adults at baseline (visit 1 2011-2014) 4.3 years later 2 2015-2019). functional parameters included were peak S’ velocity (PsV),...
Introduction: Among non-Hispanics, hypertension (HTN) disparities by self-reported race exist. Hispanics/Latinos (H/L) are an admixed population of African (AA), European (EA) and Amerindian (AI) continental genetic ancestry (GA). Few studies have explored HTN among H/L. We assessed, H/L, the associations with GA, GA HTN. Methods: Data was obtained from HCHS/SOL, a population-based cohort United States (US) included mutually unrelated subjects ≥18 years old genotyping data. Proportions...
Introduction: Right ventricle (RV) changes secondary to severe lung disease are well described, but the association of pulmonary function tests (PFTs) and subclinical airflow obstruction with RV is unexplored. Methods: Serial echocardiograms conducted 4.3 years apart on 1643 adults (mean age 56.4 years, 41.5% female) during ECHO-SOL visits 1 (2011-2014) 2 (2015-2018) were analyzed. baseline change over time (from visit 2) assessed by echocardiographic outcomes: fractional area (RVFAC, %),...
Novel furoxan/coumarin hybrids were synthesized, and pharmacologic studies showed that the compounds displayed potent antiproliferation activities via downregulating both phosphatidylinositide 3-kinase (PI3K) pathway mitogen-activated protein kinase (MAPK) pathway. To investigate preclinical pharmacokinetic (PK) properties of three candidate (CY-14S-4A83, CY-16S-4A43, CY-16S-4A93), liquid chromatography, in tandem with mass spectrometry LC-MS/MS method, was developed validated for...
Assessment of the matrix effect by a post-column infusion method and sufficient matrix–analyte separation with Synergi 4 μm Hydro-RP.
In order to improve the benefit-risk ratio of pharmacokinetic (PK) research in early development new drugs, silico and vitro methods were constructed improved. Models intrinsic clearance rate (CLint) based on quantitative structure-activity relationship (QSAR) 7882 collected compounds. Moreover, a novel metabolic method, Bio-PK dynamic system, was combined with physiology-based model (PBPK) predict metabolism drug-drug interaction (DDI) azidothymidine (AZT) fluconazole (FCZ) mediated by...