A5038982907- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Esophageal and GI Pathology
- Helicobacter pylori-related gastroenterology studies
- Chronic Disease Management Strategies
- Cerebral Palsy and Movement Disorders
- Healthcare innovation and challenges
- Infection Control and Ventilation
- COVID-19 and healthcare impacts
- Dysphagia Assessment and Management
- Geriatric Care and Nursing Homes
- Migration, Aging, and Tourism Studies
- Gastrointestinal motility and disorders
- Musculoskeletal pain and rehabilitation
- Respiratory Support and Mechanisms
- Hippo pathway signaling and YAP/TAZ
- Esophageal Cancer Research and Treatment
- Balance, Gait, and Falls Prevention
- Aging, Elder Care, and Social Issues
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Tracheal and airway disorders
- Frailty in Older Adults
- Pneumothorax, Barotrauma, Emphysema
- Proteoglycans and glycosaminoglycans research
- Global Health Care Issues
KU Leuven
2010-2025
Non-coeliac gluten sensitivity (NCGS) is a controversial entity, characterised by symptom improvement with exclusion in the absence of coeliac disease. We primarily investigated effects acute and sub-acute on psychological mood profiles, secondary outcomes examining gastrointestinal symptoms biological markers healthy controls (HC) individuals NCGS. A randomised, single-blind, crossover study used (16 g or whey yoghurt) (gluten-containing g) gluten-free muffins per day for 5 days)...
Summary Background Proton pump inhibitors (PPI) have no effect on non‐acid reflux events which can continue to provoke gastro‐oesophageal disease (GERD) symptoms. Baclofen, a γ‐aminobutyric acid agonist, decrease but its symptomatic benefit in refractory GERD symptoms is understudied. Aims To assess the efficacy of baclofen 10 mg t.i.d. vs placebo as add‐on therapy PPI‐refractory symptoms, randomised, double‐blind, placebo‐controlled study. Methods Patients with persisting typical b.i.d. PPI...
INTRODUCTION: Real-time symptom reporting during ambulatory reflux monitoring plays a key role in the evaluation of esophageal symptoms, although underlying processes are poorly understood. We aim to identify psychological and physiological factors associated with real-time symptom–reflux association parameters. METHODS: Adult patients refractory symptoms completed psychosocial questionnaires standard 24-hour pH-impedance monitoring. A hurdle-Poisson model evaluated between (proton pump...
Falls among older persons occur frequently and are a common cause of physical psychological morbidity healthcare utilization. The problem can be attributed to complex interaction between health-related, behavioral environmental factors. To ensure uniform evidence-based approach, practice guideline was developed for fall prevention in community-dwelling at risk falls.To test the feasibility integrating into daily 4 primary disciplines, i.e. general practitioners, nurses, occupational...
Historically, psychological processes are associated with disorders at the functional end of gastro-oesophageal reflux disease (GERD) spectrum. However, recent research suggests that symptoms relevant across entire GERD We aim to investigate whether phenotype (True GERD, Borderline hypersensitivity, heartburn) along spectrum in a cohort refractory patients.Consecutive adult patients underwent standard 24-hour pH-impedance monitoring and completed questionnaires assessing demographic,...
The COVID-19 pandemic, declared by WHO on March 13, 2020, had a major global impact the healthcare system and services. In acute phase, presence of SARS-CoV-2 virus in aerodigestive tract limited activities gastroenterology clinic procedures to emergencies only. Motility function testing was interrupted as we enter recovery restarting these requires safety-focused approach with adequate infection prevention for patients professionals.We summarized knowledge risk spread motility functional...
Abstract Background Esophageal hypersensitivity is considered an important pathophysiological mechanism in refractory gastroesophageal reflux disease (GERD) patients. Serotonin (5‐HT) plays role the regulation of GI (gastrointestinal) secretion, motility and sensitivity. Previous studies found that altered 5‐HT availability has no clear effects on esophageal/GI sensations. Our aim was therefore to investigate esophageal sensitivity healthy volunteers (HV). Methods thermal, mechanical,...
Chronic opioid use can induce esophageal dysfunction with symptoms resembling achalasia and a manometric pattern of esophagogastric junction-outflow obstruction (EGJ-OO). However, the effect opioids in acute setting on pharyngeal function body contractility has not been investigated.After positioning high-resolution impedance manometry (HRiM) catheter, codeine (60 mg) or placebo (glucose syrup) was infused intragastrically. Forty-five minutes post-infusion, participants received liquid,...
Cellular signaling is largely dependent on the presence, that is, assembly/disassembly, of supramolecular complexes. Postsynaptic density protein, Discs-large, Zona occludens (PDZ) domains play important roles in assembly various Syntenin-2 (S2) a PDZ protein interacts with nuclear phosphatidylinositol 4,5-bisphosphate (PIP2 ). Although lipids emerge as key players processes, global significance phosphoinositide-protein interactions still poorly understood. Those have been studied detail...
The new coronavirus disease (COVID-19) has high infection and mortality rates, become a pandemic. rates are lower in Asian countries than European countries. This study aimed to conduct survey on the effects of COVID-19 capacity perform gastrointestinal motility tests compared with countries.We used questionnaire previously established by our team for researchers correlation between decreased rate function tests, infection/mortality stringency government's interventions each country was...
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The Chicago classification primarily utilizes ten 5 mL liquid swallows in a supine position as the standard high-resolution esophageal manometry (HRM) protocol. HRM can be performed with varying volumes and consistencies an upright position. We aimed to determine impact on results by (1) position, (2) of differing volume consistency, (3) perception bolus passage.HRM was healthy volunteers (HV) following protocol swallows: liquids 10 × mL, 3 multiple rapid swallows; applesauce mL; bread 2 cm...
Aerosol spread is key to interpret the risk of viral contamination during clinical procedures such as esophageal high-resolution manometry (HRM). Installing an air purifier seems a legitimate strategy, but this has recently been questioned.Patients undergoing HRM procedure at Leuven University Hospital were included in study. All subjects had wear surgical mask which was only lowered beneath nose placement and removal nasogastric catheter. The number aerosol particles measured by Lasair® II...