A5017997459- Antibiotic Use and Resistance
- Urinary Tract Infections Management
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Otolaryngology and Infectious Diseases
- Infective Endocarditis Diagnosis and Management
- Respiratory viral infections research
- Data-Driven Disease Surveillance
- Antimicrobial Resistance in Staphylococcus
- Salmonella and Campylobacter epidemiology
- Patient Satisfaction in Healthcare
- Bacterial Identification and Susceptibility Testing
- Healthcare Policy and Management
- Nosocomial Infections in ICU
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Pharmacovigilance and Adverse Drug Reactions
- Clostridium difficile and Clostridium perfringens research
- Virology and Viral Diseases
- Antibiotic Resistance in Bacteria
- Hepatitis Viruses Studies and Epidemiology
- Vaccine Coverage and Hesitancy
Karolinska University Hospital
2009-2024
Karolinska Institutet
2014-2023
Public Health Agency of Sweden
2014-2022
Swedish Institute
2004-2013
A mismatch between a widespread use of broad-spectrum antibiotic agents and low prevalence reported bacterial co-infections in patients with SARS-CoV-2 infections has been observed. Herein, we sought to characterize compare at admission hospitalized SARS-CoV-2, influenza or respiratory syncytial virus (RSV) positive community-acquired pneumonia (CAP).A retrospective cohort study RSV-positive adult CAP admitted Karolinska University Hospital Stockholm, Sweden, from year 2011 2020. The was...
During 1997-2004, microbiologically confirmed gastrointestinal infections were reported for 101,855 patients in Sweden. Among who had Salmonella infection (n = 34,664), we found an increased risk aortic aneurysm (standardized incidence ratio [SIR] 6.4, 95% confidence interval [CI] 3.1-11.8) within 3 months after and elevated ulcerative colitis (SIR 3.2, CI 2.2-4.6) 1 year infection. We also this among Campylobacter 57,425; SIR 2.8, 2.0-3.8). Within year, reactive arthritis with Yersinia...
Infective endocarditis (IE) remains a serious disease with substantial mortality. In this study we investigated the incidence of IE, as well its associated short and long term mortality rates.The IE cases were identified in Swedish national inpatient register using ICD-10 codes, then linked to population order identify deaths cohort. Crude rates among patients obtained for different time intervals. These directly standardized sex- age-matched general population.The cohort consisted 7603...
A child with pre-B acute lymphoblastic leukaemia (ALL) developed fatal encephalitis associated human coronavirus OC43 (HCoV-OC43). During chemotherapy the had a persistent HCoV-OC43 respiratory infection and later progressive encephalitis. Cerebrospinal fluid was negative for pathogens including HCoV-OC43, but brain biopsy HCoV-OC43-positive by metagenomic next-generation sequencing.
An understanding of differences in clinical phenotypes and outcomes COVID-19 compared with other respiratory viral infections is important to optimise the management patients plan healthcare. Herein we sought investigate such positive for SARS-CoV-2 influenza, syncytial virus (RSV) viruses. We performed a retrospective cohort study hospitalised adults children (≤15 years) who tested SARS-CoV-2, influenza A/B, RSV, rhinovirus, enterovirus, parainfluenza viruses, metapneumovirus, seasonal...
Ventilator-associated lower respiratory tract infections (VA-LRTIs) are associated with prolonged length of stay and increased mortality. We aimed to investigate the occurrence bacterial VA-LRTI among mechanically ventilated COVID-19 patients compare these findings non-COVID-19 cohorts throughout first second wave pandemic.Retrospective cohort study.Karolinska University Hospital, Stockholm, Sweden.All greater than or equal 18 years treated mechanical ventilation between January 1, 2011,...
Quantifying the burden of nosocomial SARS-CoV-2 infections and associated mortality is necessary to assess need for infection prevention control measures.
Little is known of the long-term risks bloodstream infection (BSI) with extended spectrum β-lactamase–producing Enterobacteriaceae (EPE) in previously-colonized individuals. We investigated EPE-BSI and associated risk factors during 6 years following EPE colonization. performed a population-based cohort study Sweden using national health registers. Subjects were followed from their first finding feces (n = 5513) or urine 17189). The effects co-morbidity, sociodemography, outpatient...
To investigate if use of antibiotics was associated with bacterial complications following upper respiratory tract infections (URTIs).Ecological time-trend analysis and a prospective cohort study.Primary, outpatient specialist inpatient care in Stockholm County, Sweden. All analyses were based on administrative healthcare data consultations, diagnoses dispensed from January 2006 to 2016.Ecological analysis: 10-year trend the incidence URTIs, infections/complications antibiotic use....
Campylobacteriosis is one of the most commonly identified causes bacterial diarrheal disease and a common cause gastroenteritis in travellers from developed nations. Despite widespread occurrence, there little information on Campylobacter mortality.Mortality among cohort cases were compared with general population 0-1, 1-3, 3-12 more than 12 month after onset illness. The sub-grouped according to if they had been infected domestically or abroad.The standardized mortality ratio for was 2.9...
To determine the distribution of urinary tract pathogens with focus on Staphylococcus saprophyticus and analyse seasonality, antibiotic susceptibility, gender age distributions in a large Swedish cohort. S. is considered an important causative agent infection ( UTI ) young women, some earlier studies have reported up to approximately 40% s this patient group being caused by . We hypothesized that may be true only very specific outpatient settings. During year 2010, 113 720 urine samples were...
Background: Patients undergoing endovascular aneurysm repair (EVAR) due to abdominal aortic often develop an inflammatory response, postimplantation syndrome (PIS) where fever and leukocytosis are common. Previous studies suggest that type of stent graft material (polyester or polytetrafluoroethylene [PTFE]) plays a role. Objectives: To investigate the effect on response length hospital stay in patients standard elective EVAR. Methods: Sixty-nine EVAR were included this observational study....
Background: Differences in antibiotic consumption between individuals are not only due to differences primary infection morbidity, other non-medical factors important. Our objective was investigate how socio-demographic factors, co-morbidity, and access care affect prescribing. Methods: The study population included all 2 078 481 persons Sweden who received at least one prescription during 2010, an unmatched control of 788 580 individuals. We used record linkage obtain data on various...
A few years after the publication of British guidelines, national recommendations were published by Swedish Medical Products Agency in October 2012, promoting cessation antibiotic prophylaxis dentistry for prevention infective endocarditis (IE). The aim this study was to evaluate whether incidence oral streptococcal IE increased among high-risk individuals 2012.This nationwide cohort included all adult (>17 years) living Sweden from January 2008 2018, with a diagnose code or surgical...
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Abstract Background Sweden has seen an accelerated decline in the number of dispensed antibiotic prescriptions from already low level during Covid-19 pandemic. This prompted us to explore whether decrease reached a critically and resulted increase treatment severe complications common infections. The aim was study if sales led outpatients with Method A population-based nationwide registry based on Swedish Prescribed Drug Register National Patient Register. Results total decreased by 17% 2020...
Adverse economic consequences of antibiotic resistance, both in health care systems and society at large, have been estimated to emerge significantly affect the global economy. To date, most studies societal costs resistance had a macroeconomic perspective, using number attributable deaths as quantifier for production loss. In contrast, there few terms length sick leave hence impact morbidity on The aim our study was estimate loss from ill caused by resistance.To additional due we used...
It is important to measure antibiotic consumption because it contributes antimicrobial resistance. Our objective was follow all children born in 2006 Sweden and analyse during each month of life for the first two years thereafter every year their third fifth life.This a register-based, open-cohort study where we used Swedish Prescribed Drug Register, which covers whole population, identify type date purchase antibiotics cohort.During one-year follow-up period, 101 555 up one age were living...
Chronic tonsillitis (CT) and tonsillar hypertrophy (TH) are common diseases that related to infection inflammation. Little is known about microbiota its role in CT TH. This study aims identify palatine both on the surface core tissues of TH patients. In total, 22 tonsils were removed collected from patients who underwent surgery. The compared using 16S rRNA gene sequencing V3-V4 regions. Differential microbiotas found versus tissues. Further, a higher relative abundance bacterial genera,...