A5012893800- Cutaneous Melanoma Detection and Management
- Aortic aneurysm repair treatments
- Cerebrovascular and Carotid Artery Diseases
- Atherosclerosis and Cardiovascular Diseases
- Infectious Aortic and Vascular Conditions
- Vascular Procedures and Complications
- Cardiovascular Health and Disease Prevention
- Aortic Disease and Treatment Approaches
- Peripheral Artery Disease Management
- Skin Protection and Aging
- Nonmelanoma Skin Cancer Studies
- Intracranial Aneurysms: Treatment and Complications
- Cutaneous lymphoproliferative disorders research
- Melanoma and MAPK Pathways
- Acute Ischemic Stroke Management
- Optical Coherence Tomography Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Venous Thromboembolism Diagnosis and Management
- Cell Adhesion Molecules Research
- Allergic Rhinitis and Sensitization
- Infective Endocarditis Diagnosis and Management
- Advanced Biosensing Techniques and Applications
- Systemic Lupus Erythematosus Research
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
Stockholm South General Hospital
2015-2024
Karolinska Institutet
2015-2024
Uppsala University
2013-2016
Karolinska University Hospital
2016
KTH Royal Institute of Technology
2013
Novo Nordisk (Denmark)
2013
GTx (United States)
2003
No reliable comparative data exist between open repair (OR) and endovascular aneurysm (EVAR) for mycotic abdominal aortic aneurysms (MAAAs). This nationwide study assessed outcomes after OR EVAR MAAA in a population-based cohort.All patients treated MAAAs Sweden 1994 2014 were identified the Swedish vascular registry. The primary aim was to assess survival with EVAR. Secondary aims analyses of rate recurrent infections reoperations, time trends surgical treatment. Survival analyzed using...
The results of a recent meta-analysis aroused concern about an increased risk death associated with the use paclitaxel-coated angioplasty balloons and stents in lower-limb endovascular interventions for symptomatic peripheral artery disease.
PURPOSE: This study was designed to evaluate the results of rectocele repair and parameters that might be useful in selecting patients for this operation. METHODS: Twentyfive with symptom-giving rectoceles were prospectively evaluated a standardized questionnaire, physical examination, defecography, colon transit studies, anorectal manometry, electrophysiology. Patients underwent posterior colporrhaphy perineorrhaphy. They followed postoperatively (mean, 1.0 year) same RESULTS: Constipation...
Objective— Carotid plaque instability is a major cause of ischemic stroke, but detailed knowledge about underlying molecular pathways still lacking. Here, we evaluated large-scale transcriptomic and protein expression profiling in biobank carotid endarterectomies followed by characterization identified candidates, as platform for discovery novel proteins differentially regulated unstable lesions. Approach Results— Genes highly upregulated symptomatic versus asymptomatic plaques were selected...
Mycotic aortic aneurysms are rare, life threatening, and complex. This nationwide study aimed to assess outcome after repair of mycotic thoracic (MTAAs).Patients treated in Sweden for MTAAs between 2000 2016 were identified the Swedish vascular registry (2010-16) local patient registries (2000-09). Primary was survival, secondary outcomes included surgical strategy, rate infection related complications (IRC), re-operations.Fifty-two patients (median age 71 ± 8.1 years; 28 [54%] men, 13 [25%]...
To evaluate if ticagrelor, an effective platelet inhibitor without known non-responders, could inhibit growth of small abdominal aortic aneurysms (AAAs).In this multi-centre randomized controlled trial, double-blinded for ticagrelor and placebo, acetylic salicylic acid naïve patients with AAA a maximum diameter 35-49 mm were included. The primary outcome was mean reduction in log-transformed volume rate (%) measured magnetic resonance imaging (MRI) at 12 months compared baseline. Secondary...
Clinical tools to identify individuals with unstable atherosclerotic lesions are required improve prevention of myocardial infarction and ischemic stroke. Here, a systems-based analysis plaques plasma from patients undergoing carotid endarterectomy for stroke was used molecular signatures causal relationship disease. Local collected in the lesion proximity following clamping prior arteriotomy profiled together matched peripheral plasma. This translational workflow identified biliverdin...
PCSKs (Proprotein convertase subtilisins/kexins) are a protease family with unknown functions in vasculature. Previously, we demonstrated PCSK6 upregulation human atherosclerotic plaques associated smooth muscle cells (SMCs), inflammation, extracellular matrix remodeling, and mitogens.Here, applied systems biology approach to gain deeper insights into the role normal diseased vessel wall.Genetic analyses revealed association of intronic variant rs1531817 maximum internal carotid intima-media...
The incidence of cutaneous malignant melanoma (CMM) and in situ (MIS) has been increasing during the last 50 years. Malignant (MM) is also most common intraocular malignancy (IMM). Besides ultraviolet radiation, cause these tumours largely unknown.We designed a study to examine effect body mass index (BMI) tobacco use on risk for MM MIS.Analyses were performed nationwide cohort 339 802 Swedish construction workers. Exposure information was collected prospectively by questionnaires combined...
Atherosclerosis is characterized by the presence of activated immune-competent cells including dendritic (DCs) and T cells, dead oxidized low-density lipoprotein. HSP60 (Heat shock protein 60) has been implicated in atherosclerosis. A plasma protein, Annexin A5, atheroprotective properties.Human DCs differentiated from peripheral blood monocytes were treated with human or HSP90 autologous cocultured these pretreated (mDCs). induced mDCs T-cell activation as determined FACScan (Fluorescence...
The prognostic impact of different anatomical sites in patients with cutaneous malignant melanoma (CMM) has been widely debated and requires further elucidation. Therefore, we developed EssDoll©, a new computerized method to address the question site relation prognosis. A population-based cohort 1891 patients, diagnosed between 1976 1987 invasive CMM without evidence metastasis, was identified. body surface divided into 24 areas. Hazard ratios (HRs) for death were calculated areas compared...
Since cutaneous malignant melanoma (CMM) and in situ (MIS) of the head neck have only partially been differentiated from CMM other anatomic sites, these lesions are classified detail this study. Data 756 patients derived population-based register Stockholm-Gotland area were analyzed findings showed that incidence was 3.4 times higher face compared to skin outside head-neck lentigo maligna 74 nodular 2.3 more common face. Mean age at diagnosis significantly for with irrespective histogenetic...
Abstract Objectives/Hypothesis For cutaneous malignant melanoma (CMM) of the head and neck, neither prognostic factors in population‐based groups, nor outcome with respect to surgical resection margins is clear. Therefore, we analyzed data a regional registry align treatment results for CMM neck prognosis survival times. Study Design Patient material collected prospectively an 18‐year period Swedish cancer underwent statistical analyses establish most reliable influence on patients neck....
Background: Patients undergoing endovascular aneurysm repair (EVAR) due to abdominal aortic often develop an inflammatory response, postimplantation syndrome (PIS) where fever and leukocytosis are common. Previous studies suggest that type of stent graft material (polyester or polytetrafluoroethylene [PTFE]) plays a role. Objectives: To investigate the effect on response length hospital stay in patients standard elective EVAR. Methods: Sixty-nine EVAR were included this observational study....
Abdominal aortic graft and endograft infection (AGI) is primarily treated by resection of the infected restoration distal perfusion through extra-anatomic bypass (EAB) or in situ reconstruction/repair (ISR). The aim this study was to compare these surgical strategies a nationwide multicentre retrospective cohort study.The Swedish Vascular Registry (Swedvasc) used identify surgically abdominal AGIs Sweden between January 1995 May 2017. primary short long term survival, as well complications...
Carotid endarterectomy (CEA) is an effective surgical method for stroke prevention in selected patients with carotid stenosis. Few contemporary studies report on the long term mortality rate CEA treated patients, despite continuous changes medication, diagnostics, and patient selection. Here, described a well characterised cohort of asymptomatic symptomatic sex differences evaluated, ratio compared general population.This was two centre, non-randomised, observational study evaluating all...
Given the wide public health implications of melanoma epidemic, ultraviolet radiation (UVR) exposure patterns contributing to cutaneous development should be clearly identified. To describe time trends anatomic sites using a UVR model based on clothing and sun habits, we reviewed medical records all patients diagnosed with primary invasive or in situ (MIS) during years 1977-78, 1983-84, 1989-90, 1995-96, 2000-01 (n=3058) one healthcare region Sweden. Age-standardized incidence rates relative...
Abdominal aortic graft and endograft infections (AGIs) are rare complications following surgery. Radical surgery (RS) with resection of the infected reconstruction extra-anatomical bypass or in situ is preferred therapy. For patients unfit for RS, a semi-conservative (SC), preserving strategy possible. This paper aimed to compare survival infection outcomes between RS SC treatment AGI nationwide cohort.Patients abdominal related Sweden January 1995 May 2017 were identified. The Management...