A5047785527- Retinal Diseases and Treatments
- Peripheral Nerve Disorders
- Reconstructive Surgery and Microvascular Techniques
- Nerve injury and regeneration
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Medical Imaging and Analysis
- Nerve Injury and Rehabilitation
- Orthopedic Surgery and Rehabilitation
- Cerebral Venous Sinus Thrombosis
- Protease and Inhibitor Mechanisms
- Bone fractures and treatments
- Spinal Cord Injury Research
- Advanced battery technologies research
- Meat and Animal Product Quality
- Electrochemical Analysis and Applications
- Retinal Development and Disorders
- Agricultural Engineering and Mechanization
- Electrospun Nanofibers in Biomedical Applications
- Microbial Metabolism and Applications
- Bone Tissue Engineering Materials
- Shoulder Injury and Treatment
- Advanced oxidation water treatment
- Soil Mechanics and Vehicle Dynamics
- Tendon Structure and Treatment
Sun Yat-sen University
2011-2023
The First Affiliated Hospital, Sun Yat-sen University
2011-2023
Anhui Agricultural University
2021-2023
Key Laboratory of Guangdong Province
2018-2023
Cleveland Clinic Lerner College of Medicine
2009-2022
Cleveland Clinic
2002-2021
Cleveland Eye Clinic
2002-2021
Jinan City People's Hospital
2020
Shandong First Medical University
2020
Beijing University of Agriculture
2016-2019
Sorsby's fundus dystrophy (SFD) is an autosomal dominant degenerative disease of the macula caused by mutations in tissue inhibitor metalloproteinase-3 (TIMP-3) gene. Choroidal neovascularization a hallmark this disease, which closely resembles exudative form age-related macular degeneration. However, mechanism TIMP-3 induce phenotype SFD remains unknown. To address question we established human retinal pigment epithelial cell lines expressing wild type or S156C (Ser<sup>156</sup> changed to...
Abstract Although success of digital replantations in children has been reported by many authors, the very distal fingertip replantation remains technically demanding. The aim this article is to review our experience with at or nail base pediatric patients and evaluate clinical outcomes. From October 2000 May 2007, 12 fingertips amputated were replanted. Only one artery was anastomosed for revascularization without nerve repair; vein drainage provided controlled bleeding technique. Eleven...
Tissue Inhibitor of metalloproteinases-3 (TIMP-3) is a potent matrix-bound angiogenesis inhibitor. Mutations in TIMP-3 cause Sorsby Fundus Dystrophy, dominant inherited, early onset macular degenerative disease, with choroidal neovascularization causing loss vision the majority patients. Here we report that expression S156C mutation endothelial cells results an abnormal localization protein, increased glycosylation, decreased matrix metalloproteinase inhibitory activity, and vascular growth...
Abstract In the study, functional recovery and relative comprehensive quality of life cases global brachial plexus treated with free functioning muscle transfers were investigated. Patients who received gracilis transfer between August 1999 October 2014 to reconstruct elbow flexion, wrist fingers extension recruited. The mean age patients was 26.36 (range, 16–42) years. period time from last follow-up 54.5 months 12–185 months). Muscle power, active range motion total recorded. SDS, SAS DASH...
Real-time crop harvest data acquisition from harvesters during harvesting operations is an important way to understand the distribution of in field. Most real-time monitoring systems for grain yield using sensors are vulnerable factors such as low accuracy and performance. To address this phenomenon, a system was designed study. The accomplished by adding three pairs photoelectric elevator corn kernel harvester. mainly consists signal processing module, positioning module visualization...
Abstract Peripheral nerves are important pathways for receiving afferent sensory impulses and sending out efferent motor instructions, as carried by nerve fibers fibers. It has remained a great challenge to functionally reconnect internal fiber bundles (or fascicles) in repair. One possible solution may be establish 3D fascicle visualization system. This study described the key technology of peripheral reconstruction. Firstly, fixed segments were embedded with position lines,...
Abstract Choroidal neovascularization (CNV) leads to loss of vision in patients with Sorsby Fundus Dystrophy (SFD), an inherited, macular degenerative disorder, caused by mutations the Tissue Inhibitor Metalloproteinase-3 ( TIMP3 ) gene. SFD closely resembles age-related degeneration (AMD), which is leading cause blindness elderly population Western hemisphere. Variants gene have recently been identified AMD. A majority AMD also lose as a consequence choroidal (CNV). Thus, understanding...
Catechin, epicatechin and chlorogenic acid are widely distributed in the plant kingdom. At present, influencing factors of phenol chemical oxidation is little research. In order to study non-enzymatic browning factors, this research utilized catechin, establish simulation systems. The degree products flavanols were investigated by transmittance high-performance liquid chromatography (HPLC). main results conclusions follows. brown generation increased after phenols at 50°C pH 3.7 phosphate...
Complex limb trauma often involves both soft tissue and vascular defects, is challenging for surgeons. The traditional musculocutaneous flap cannot achieve a 3-dimensional wound repair. Here we report our experience with single-stage reconstruction revascularization performed on complex extremity injuries using free flow-through chimeric anterolateral thigh perforator (ALTP) flap.Seventeen patients (16 men; aged 19-55 years) defects attended hospital from January 2010 to November 2017. All...
The most common methods for three-dimensional reconstruction of peripheral nerve fascicles include histological and radiology techniques. Histological techniques have many drawbacks including an enormous manual workload poor image registration. Micro-magnetic resonance imaging (Micro-MRI), emerging technique, has been used to report results in the brain, liver tumor tissues. However, micro-MRI usage obtaining intraneural structures not reported. aim this study was present a new method by 1T...
Brachial plexus injuries (BPI) are devastating events that frequently result in severe functional impairment of the upper extremity, and yet, present surgical reconstruction provides limited results. An animal model is an important tool to study peripheral nerve repair regeneration. Here, a passive traction apparatus allowed multidirectional force exerted on fixed forelimb was designed produce BPI rat noninvasive manner. Behavioral histological analyses were carried out assess suitability...
Objective . The use of a biofabrication nerve scaffold, which mimics the microstructure, as an alternative for autologous transplantation is promising strategy treating peripheral defects. This study aimed to design customized scaffold model with characteristics human fascicles. Methods We used Micro-MRI technique obtain different A full-length 28 cm tibial specimen was obtained and divided into 14 two-centimetre segments. 3D models fascicles were by three-dimensional reconstruction after...
Sorsby's fundus dystrophy (SFD) is an inherited blinding disorder caused by mutations in the tissue inhibitor of metalloproteinase-3 (TIMP3) gene. The SFD pathology macular degeneration with subretinal deposits and choroidal neovascularization (CNV) closely resembles that more common age-related (AMD). objective this study was to gain further insight into molecular mechanism(s) which mutant TIMP3 induces CNV. In we demonstrate hyaluronan (HA), a large glycosaminoglycan, elevated plasma...
Abstract Biofabricated nanostructured and microstructured scaffolds have exhibited great potential for nerve tissue regeneration functional restoration, prevascularization biotransportation within 3D fascicle structures are critical. Unfortunately, an ideal internal microvascular model of human peripheral nerves is lacking. In this study, we used microcomputed tomography (microCT) to acquire high‐resolution images the sciatic nerve. We propose a novel deep‐learning network technique, called...
The virtual human plan has been the hot point of recent research. objective this study is to explore possibility three-dimensional (3D) reconstruction functional fascicular groups inside short segmental peripheral nerve. A 5 cm length common peroneal nerve was horizontally sliced at 0.25 mm intervals, and each section stained with acetycholinesterase histochemical staining. 2D panorama images were acquired by high-resolution digital camera under 100 x microscope mosaic software; different...
The present work discloses the use of Erythrina senegalensis leaf extract for reduction graphene oxide (GO) via a simple one pot technique by avoiding toxic reducing agents. effective GO and consequent capping oxidized plant polyphenols were demonstrated different spectroscopic microscopic studies. Fourier-transform infrared (FTIR) spectroscopy indicated stabilization RGO with extract. Transmission electron microscopy (TEM) images confirmed thin, transparent, silk sheet like structure RGO....