A5020085640- Cancer Genomics and Diagnostics
- Interprofessional Education and Collaboration
- CAR-T cell therapy research
- COVID-19 and healthcare impacts
- Cancer Immunotherapy and Biomarkers
- Chromosomal and Genetic Variations
- Mental Health Treatment and Access
- Innovations in Medical Education
- Cancer-related molecular mechanisms research
- Mental Health and Patient Involvement
- Genetic factors in colorectal cancer
- Head and Neck Cancer Studies
- Infection Control and Ventilation
- Genomics and Phylogenetic Studies
- Immune Cell Function and Interaction
- Ethics in medical practice
- Ovarian cancer diagnosis and treatment
- Pharmaceutical Practices and Patient Outcomes
- COVID-19 and Mental Health
- Colorectal Cancer Treatments and Studies
- Monoclonal and Polyclonal Antibodies Research
- Biosimilars and Bioanalytical Methods
- Respiratory viral infections research
- Autoimmune and Inflammatory Disorders Research
- Salivary Gland Disorders and Functions
Exact Sciences (United States)
2025
Monash University
2024
Victorian Institute of Forensic Medicine
2015-2024
Coherus BioSciences (United States)
2024
The Ohio State University
2007-2021
Austin Health
2020-2021
Baptist Hospital of Miami
2021
Baptist Health South Florida
2021
Pacific Biosciences (United States)
2020
Capital and Coast District Health Board
2017-2020
The PacBio® HiFi sequencing method yields highly accurate long-read datasets with read lengths averaging 10-25 kb and accuracies greater than 99.5%. These long reads can be used to improve results for complex applications such as single nucleotide structural variant detection, genome assembly, assembly of difficult polyploid or repetitive genomes, metagenomes. Currently, there is a need sample data sets both evaluate the benefits these well development bioinformatic tools including...
ABSTRACT Background and Objectives Identification of colorectal cancer (CRC) patients at high risk recurrence could be substantial clinical use. We evaluated the association ctDNA status, using a tumor‐informed assay, with recurrence‐free survival (RFS). Methods Stage III CRC were enrolled between 2016 2020. Tumor tissue serial (every 3 months for years 1–3, biannually 4–5) blood samples collected. Utilizing whole‐exome sequencing selection 50–200 variants tumor informed assays, status was...
BackgroundHigh rates of healthcare worker (HCW) infections due to COVID-19 have been attributed several factors, including inadequate personal protective equipment (PPE), exposure a high density patients with COVID-19, and poor building ventilation. We investigated an increase in the number staff at our hospital determine factors contributing infection implement interventions required prevent subsequent infections.MethodsWe conducted single-centre retrospective cohort study working tertiary...
302 Background: Patients with stage III CRC undergo surgery and adjuvant chemotherapy. Evaluation of MRD using a highly sensitive specific, tumor-informed ctDNA assay may help predict which patients will have recurrence. Methods: were enrolled after in an observational study across 19 Pennsylvanian hospitals between 2016-2020. Tumor tissue serial blood samples (every 3 months for years 1-3, biannually 4-5) collected. Following whole exome sequencing (WES) the tumor selection 50 – 200 somatic...
Objectives: Higher catabolic clearance (CL) of immune checkpoint inhibitors (ICIs) is a biomarker for less favorable outcomes, independent drug exposure, in patients with cancer, thus leading to confounded exposure-response relationships. Patients rapid mAb CL present cancer cachexia phenotypes[1,2], though underlying mechanisms linking high CL, poor response, and are poorly understood. Our previous research demonstrates elevated ICIs can be replicated mouse models cachexia, the increased...
Background To evaluate, in a cohort study, whether coronary microvasculature and myocardial structure differ between people with without artery disease (CAD). Methods Results We performed histological analysis of left ventricle free wall obtained at autopsy from 25 men 23 women ≥1 ≥75% area stenosis, (no or minimal) CAD, matched for sex age, who died suddenly noncardiac causes. Decedents infarction other cardiac abnormality were excluded. CAD had similar height weight. Heart weight decedents...
Individuals with high prevalence mental health (HPMH) and concurrent alcohol and/or drug disorders are vulnerable to falling ‘between the gaps’ of existing service systems. The aim current qualitative study was explore experiences (barriers treatment suggestions for improvements) from perspective those this type dual diagnosis. Of individuals, 44 a HPMH diagnosis participated in interviews. Thematic analysis conducted on data major themes presented. Barriers related primarily knowledge (not...
Abstract The PacBio ® HiFi sequencing method yields highly accurate long-read datasets with read lengths averaging 10-25 kb and accuracies greater than 99.5%. These long reads can be used to improve results for complex applications such as single nucleotide structural variant detection, genome assembly, assembly of difficult polyploid or repetitive genomes, metagenomes. Currently, there is a need sample data sets both evaluate the benefits these well development bioinformatic tools including...
Mucin expression patterns have been studied in tumors from various sites. Previous studies shown an association of MUC1 with poor prognosis and MUC2 MUC5AC a mucinous phenotype. The pattern mucin endometrial carcinomas has not documented large series. We determined the profile evaluated relationship between clinical-pathologic parameters. A tissue microarray 310 cases carcinoma known clinical outcome was constructed formalin-fixed, paraffin-embedded donor blocks using two 0.6 mm cores each...
Aim To catalogue and compare the pattern of metastatic disease in germline BRCA1/2 pathogenic mutation carriers non‐carriers with breast, ovarian prostate cancer from a rapid autopsy programme. Methods results The number metastases major body systems proportion participants were documented 50 (19 carriers). Analysis was conducted on participants’ for different cancers subgroups. four commonly affected organ digestive (liver only) (82%), respiratory (76%), gastrointestinal (65%)...
In 2003, the Institute of Medicine recommended that interprofessional education be incorporated into training programs health care professionals. However, many logistical challenges hinder formal learning in profession programs.This resource is a 3-hour small-group session designed for professions student teams to engage standardized patient encounter, each team member contributing profession-specific perspective create collaborative plan across five discharge decisions. The activity...
The regioselectivity of the addition 2,4,6-trimethylphenol to 2,4-dichloro-3,6-dimethylpyridine can be controlled by proper choice catalyst and solvent. use catalytic copper(I) salts pyridine as solvent results in exclusive at C-2. In their absence, a mixture regioisomers is obtained which C-4 dominant.
This paper reports on the development of a care-pathway to improve service linkages between acute setting and community health services in treatment low back pain. The pathway was informed by two processes: (1) literature review based best-practice guidelines assessment, continuity care for pain patients; (2) consultation with staff key stakeholders. Stakeholders from both sectors comprised Working Group, who identified central areas concern be addressed care-pathway, goal preventing...
An online survey and focus groups were conducted, providing qualitative information on the work-life balance of psychiatrists trainees in Australasia.An invitation to participate an anonymous welfare was emailed all Royal Australian New Zealand College Psychiatrists trainees, Fellows, Affiliates. Following this, nine held across Australia Zealand.Responses received thematically analysed. The emergent patterns are presented this report.Our research suggests that can be subjectively...
Interleukin-2 (IL-2) and interferon-α (INF-α) are biologic modifiers that have met with limited clinical success in the treatment of human malignancies. We conducted a phase 2 trial IL-2-IFN-α patients advanced or unresectable squamous cell carcinoma upper aerodigestive tract. Two were analyzed sequentially for serum induction phase–blocking factors lymphokine-activated killer (LAK) activity their therapy. Serum also modulated LAK independent autologous allogeneic effector cells....
Assessing decision-making capacity to health care is within the scope of practice for all doctors, yet experience GPs in this area unknown.To explore experiences, perspectives, approaches and challenges New Zealand when conducting assessments.Qualitative study design comprising individual in-depth semi-structured interviews conducted with a convenience sample GPs. Interview transcripts were transcribed verbatim analysed using thematic analysis approach.Twelve participants recruited. The...