Chen Jin

ORCID: 0009-0001-2821-1972
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About
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Research Areas
  • Natural product bioactivities and synthesis
  • Advancements in Transdermal Drug Delivery
  • HIV/AIDS Research and Interventions
  • Antibiotics Pharmacokinetics and Efficacy
  • Ginseng Biological Effects and Applications
  • Heavy Metal Exposure and Toxicity
  • HIV/AIDS drug development and treatment
  • Natural Compounds in Disease Treatment
  • HIV Research and Treatment
  • Cardiac Imaging and Diagnostics
  • Toxic Organic Pollutants Impact
  • Fungal Biology and Applications
  • Medicinal plant effects and applications
  • Drug Solubulity and Delivery Systems
  • Tryptophan and brain disorders
  • Research on Leishmaniasis Studies
  • Endometrial and Cervical Cancer Treatments
  • Phytochemicals and Antioxidant Activities
  • Immune Response and Inflammation
  • Antibiotic Use and Resistance
  • Allergic Rhinitis and Sensitization
  • Traditional Chinese Medicine Analysis
  • NF-κB Signaling Pathways
  • Cardiovascular Function and Risk Factors
  • Rheumatoid Arthritis Research and Therapies

The Affiliated Yongchuan Hospital of Chongqing Medical University
2025

Chongqing Medical University
2025

Shenzhen University
2024

Guangzhou University
2024

Zhuhai Institute of Advanced Technology
2023

Jilin University
2023

National Center for AIDS/STD Control and Prevention,China CDC
2023

Shenyang Pharmaceutical University
2022

Jiangxi University of Traditional Chinese Medicine
2018-2021

Chinese Center For Disease Control and Prevention
2011

Renal fibrosis is the result of all chronic kidney diseases and becoming a major global health hazard.

10.1039/d4tb00737a article EN Journal of Materials Chemistry B 2024-01-01

Pulsatilla chinensis (Bunge) Regel is a commonly used Chinese medicine for clearing away heat and detoxification, cooling blood, stopping dysentery, anti-inflammatory effects. saponins (PRS) have been identified to be responsible producing these pharmacological activities. Studies shown that decoction has good therapeutic effect on ulcerative colitis (UC), however, the of PRS UC not reported. Therefore, purpose this study was investigate possible anti-UC activity using dextran sulfate sodium...

10.3389/fcimb.2021.728929 article EN cc-by Frontiers in Cellular and Infection Microbiology 2021-11-05

Psoriasis risk can be affected by exposure to mixtures of environmental chemicals; however, the effect brominated flame retardants (BFRs) on self-reported psoriasis has not been assessed. Herein, we evaluated association between BFRs compounds 6 chemicals with psoriasis. Based data from National Health and Nutrition Examination Survey (NHANES) 2003-2006 2009-2014, this analysis was conducted among 6340 adults. Multivariable logistic regression, restricted cubic splines (RCS), weighted...

10.1016/j.ecoenv.2025.117836 article EN cc-by-nc-nd Ecotoxicology and Environmental Safety 2025-02-01

Background With the aging global population, older adult atopic dermatitis (AD) is emerging as an increasingly significant health challenge. This study aimed to evaluate burden of AD from 1990 2021 and project its change 2050. Methods The estimates 95% uncertainty intervals prevalence, incidence, disability-adjusted life-years (DALYs) attributable among individuals aged over 60 years were extracted Global Burden Diseases (GBD) Study 2021. We used joinpoint regression analysis, decomposition...

10.3389/fpubh.2025.1569119 article EN cc-by Frontiers in Public Health 2025-04-02

Emerging HIV drug resistance caused by increased usage of antiretroviral drugs (ARV) could jeopardize the success standardized management protocols in resource-limited settings.We aimed to characterize pretreatment (PDR) among HIV-positive individuals and risk factors China 2022.This cross-sectional study was conducted using 2-stage systematic sampling according World Health Organization's surveillance guidelines 8 provincial-level administrative divisions 2022. Demographic information...

10.2196/50894 article EN cc-by JMIR Public Health and Surveillance 2023-10-06

Abstract In this study, we established a new pattern for differentiating and comprehensively evaluating the quality of fermented Cordyceps sinensis based on high‐performance liquid chromatography (HPLC) fingerprint analysis combined with similar (SA), principal component (PCA), hierarchical cluster (HCA), quantitative multicomponents by single marker (QAMS). These methods indicated that samples could be categorized into one class PCA HCA. The fingerprints were established, four HPLC peaks...

10.1111/1750-3841.15412 article EN Journal of Food Science 2020-09-12

Coronary artery spasm has been known to induce ischaemia and ventricular arrhythmias. We present a case of recurrent fibrillation caused by spasm-associated transmural myocardial ischaemia. During an intra-coronary acetylcholine provocation test, severe coronary could be induced. The patient was treated with hybrid approach medication implantable defibrillator.

10.1093/europace/eun292 article EN EP Europace 2008-11-02

Treatments of inflammatory bowel disease (IBD) are diverse, but their efficacy is limited, and it therefore urgent to find better therapies. Controlling mucosal inflammation a must in IBD drug treatment. The occurrence anti-tumor necrosis factor α (TNF-α) monoclonal antibodies has provided safer more efficacious therapy. However, this kind treatment still faces failure the form loss response. β-Carboline alkaloids own an anti-inflammatory pharmacological activity. While Kumujan B contains...

10.3389/fphar.2024.1427340 article EN cc-by Frontiers in Pharmacology 2024-08-01

The aim of this study was to prepare triptolide and ferulic acid ethosomes gel, investigate its transdermal permeation, compare the results with ordinary gel cream. Improved Franz diffusion cell method used in delivery experiment rat abdominal skin as vitro model. receptor fluid at different time points collected; concentration determined by high performance liquid chromatography (HPLC) chromatography-electrospray ionization mass spectrometry (LC-MS/MS). Then penetration rate, volume reserve...

10.19540/j.cnki.cjcmm.20171218.006 article EN PubMed 2018-03-01

Topical administration of triptolide (TP) is effective in the treatment rheumatoid arthritis (RA), but it can also induce skin irritation. Previous studies have used data mining strategies to analyze application <em>Tripterygium wilfordii</em> RA and shown that TP ferulic acid&nbsp;(FA) be combination due their component compatibility. The aims present study were investigate mechanisms underlying effects identify its on metabolism oxidative damage skin. MTT assay results suggested HaCaT cell...

10.3892/etm.2020.9286 article EN Experimental and Therapeutic Medicine 2020-10-06

<sec> <title>BACKGROUND</title> Emerging HIV drug resistance caused by increased usage of antiretroviral drugs (ARV) could jeopardize the success standardized management protocols in resource-limited settings. </sec> <title>OBJECTIVE</title> We aimed to characterize pretreatment (PDR) among HIV-positive individuals and risk factors China 2022. <title>METHODS</title> This cross-sectional study was conducted using 2-stage systematic sampling according World Health Organization’s surveillance...

10.2196/preprints.50894 preprint EN 2023-07-17

<h3>Introduction</h3> Physical activity is associated with cardiovascular risk in Western populations but evidence from the Chinese population limited. <h3>Methods</h3> We examined baseline data on over 500 000 people aged 30–79 years who, during 2004–2008, were recruited into a prospective study 10 regions China. Information physical was collected using an interviewer-administered questionnaire that enquired about frequency, duration and intensity of work-related leisure activities. Total...

10.1136/jech.2011.142976i.1 article EN Journal of Epidemiology & Community Health 2011-08-01

Background Heavy alcohol intake increases the risk of incident hypertension, but relationship between light-to-moderate consumption and hypertension remains controversial. Liquor was very popular in men north china. This study examed association liquor china during four years follow-up. Methods KaiLuan is a population-based cohort for cardiovascular prevention, which enrolled 101,510 employees (men 81,110) from Kailuan coal group Tangshan city China June 2006 to September 2007. We...

10.1097/01.hjh.0000408067.29828.bb article EN Journal of Hypertension 2011-11-01

In this work, the subcritical water extraction technology was used to extract alkaloids from Macleaya cordata, and effects of temperature time on its yield were investigated find best conditions. Moreover, antioxidant capacity antibacterial activity cordata studied. Furthermore, through single-factor method, it found that properly increasing prolonging conducive alkaloid yield. Still, a considerable amount might be decomposed by heat, resulting in decrease their The results showed optimal...

10.1002/cbdv.202300048 article EN Chemistry & Biodiversity 2023-06-24
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