Reese Baxter
A5021288729- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Liver Disease and Transplantation
- Pancreatic function and diabetes
- Pancreatitis Pathology and Treatment
Indiana University School of Medicine
2023-2025
Indiana University – Purdue University Indianapolis
2023-2025
Collagen is the main cargo of secretory pathway, contributing to hepatic fibrogenesis due extensive accumulation extracellular matrix. An excess collagen deposition a characteristic feature several chronic liver diseases. overproduction imposes pressure on altering endoplasmic reticulum (ER) proteostasis. Here we investigated possible contribution unfolded protein response UPR, adaptive pathway that monitors and adjusts production capacity at ER, biogenesis disease. Genetic ablation ER...
Abstract Collagen is one the most abundant proteins and main cargo of secretory pathway, contributing to hepatic fibrosis cirrhosis due excessive deposition extracellular matrix. Here we investigated possible contribution unfolded protein response, adaptive pathway that monitors adjusts production capacity at endoplasmic reticulum, collagen biogenesis liver disease. Genetic ablation ER stress sensor IRE1 reduced damage diminished in models triggered by carbon tetrachloride (CCl 4 )...