A5101969053- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Immune cells in cancer
- Medicinal Plants and Bioactive Compounds
- Bioactive Compounds in Plants
- Polysaccharides and Plant Cell Walls
- Plant Pathogens and Fungal Diseases
- Gut microbiota and health
- Pharmacological Effects of Natural Compounds
- Inflammasome and immune disorders
- Immunotherapy and Immune Responses
- Plant and Fungal Interactions Research
- Phytochemical Studies and Bioactivities
- RNA Research and Splicing
- Forest Insect Ecology and Management
- Optimism, Hope, and Well-being
- Plant Disease Resistance and Genetics
- Angiogenesis and VEGF in Cancer
- Glaucoma and retinal disorders
- Plant Virus Research Studies
- Animal Vocal Communication and Behavior
- Soft tissue tumors and treatment
- Silicon Effects in Agriculture
- Plant Molecular Biology Research
- Yeasts and Rust Fungi Studies
Soochow University
2018-2025
Nanjing Medical University
2025
University of Rome Tor Vergata
2022-2025
Guangzhou Medical University
2025
Shandong University
2024
Hunan Institute of Microbiology
2024
Jilin University
2019-2023
Capital Medical University
2019-2022
Anhui Agricultural University
2022
First People's Hospital of Chongqing
2022
Dysbiosis causes continuous progress of inflammatory bowel disease (IBD).
Immune checkpoint blockade (ICB) has shown long‐term survival benefits, but only in a small fraction of cancer patients. Recent studies suggest that improved vessel perfusion by ICB positively correlates with its therapeutic outcomes. However, the underlying mechanism such process remains unclear. Here, we show anti‐cytotoxic T‐lymphocyte‐associated protein 4 (CTLA4) treatment‐induced tumor normalization was accompanied an increased infiltration eosinophils into breast tumors. Eosinophil...
Antiangiogenic agents are commonly used in lung and colon cancer treatments, however, rapid development of drug resistance limits their efficacy.Lentinan (LNT) is a biologically active compound extracted from Lentinus edodes. The effects LNT on tumor angiogenesis were evaluated by immunohistochemistry murine LAP0297 CT26 colorectal models. impacts immune cells gene expression tissues determined flow cytometry, qPCR, ELISA. Nude mice IFNγ blockade to investigate the mechanism affecting...
Significance Cancer immunotherapy demonstrates durable clinical efficacy but only in a small percentage of cancer patients. The aberrant tumor blood vessels and resulting hypoxic microenvironment are major obstacles to hinder immunotherapy. Tumor vascular normalization is promising strategy overcome these hindrances; however, the normalizing effects induced by current available approaches often transient, limiting its therapeutic benefits. Here, we show that Delta-like 1 (DLL1) can induce...
Anlotinib is a new multitarget tyrosine kinase inhibitor for tumor angiogenesis, and its monotherapy exhibits decent clinical efficacy. However, the process of combining immune checkpoint therapy to achieve optimal antitumor effects while limiting side remains unclear. In this study, we found that effective low-dose was sufficient inhibit growth reducing compared with high doses. Effective treatments induced durable vascular normalization improved anti-PD-1 in both short- long-term treatment...
Objective Although smart senior care services offer numerous benefits, they have not yet gained widespread acceptance among the general populace, particularly seniors. Numerous related issues surfaced, with structural imbalance between supply and demand being most prominent. Currently, there is a lack of research distinguishing various categories for ageing associated behaviors older individuals. In this study, we aimed to identify types utilization Chinese adults understand their diverse...
Immune checkpoint blockade (ICB) therapy only induces durable responses in a subset of cancer patients. The underlying mechanisms such selective efficacy remain largely unknown. By analyzing the expression profiles immune molecules different statuses murine tumors, we found that tumor progression generally randomly upregulated multiple checkpoints, thus increased Heterogeneity Signature (HIS) and resulted immunotherapeutic resistance. Interestingly, overexpressing one pivotal hindered...
Abstract Objectives To assess the effect of plan complexity on dosimetric alterations induced by multi-leaf collimator (MLC) misplacements in volumetric modulated arc therapy (VMAT). Methods VMAT plans for 14 cervical and 10 lung cancer cases were reoptimized utilizing three distinct Aperture Shape Controller settings (none, very high, low), resulting groups: ASC-none, ASC-vh, ASC-vl. Four types MLC position errors simulated: total shifts (Type 1), open/closed 2), right-side 3), left-side...
Blood-brain barrier (BBB) disruption is a key pathophysiological factor of intracerebral hemorrhage (ICH). The level zonula occludens-1 (ZO-1) has been closely associated with the degree BBB damage, and an indicator destruction. aim present study was to evaluate effects rhubarb on function in rat model ICH. ICH induced rats by treatment type VII collagenase. Sham-operated were administered equal volume saline. Following administration decoction (20 g/kg), neurobehavioral evaluation Evans...
Salidroside (Sal), as a major glycoside extracted from Rhodiola rosea L., has exhibited its mighty anti-aging, anti-oxidant, anti-cancer, anti-inflammation, and neuroprotective effects in many diseases. Recently, it showed protective effect colitis mice by activating the SIRT1/FoxOs pathway. Whereas, is not known whether Sal other mechanisms on dextran sulfate sodium (DSS)-induced mice. In this study, we investigated of DSS-induced The results demonstrated was competent candidate treatment...
Current biomarkers for predicting immunotherapy response in non-small-cell lung cancer (NSCLC) are derived from invasive procedures with limited predictive accuracy. Thus, identifying a non-invasive biomarker would improve patient stratification and precision immunotherapy. In this retrospective multicohort study, the discovery cohort included 205 NSCLC patients screened ORIENT-11 an external validation (EV) 99 real-world patients. The 'onion-mode segmentation' method was developed to...
Identification of novel anti-tumor target is crucial for cancer diagnosis, prognosis, and therapeutic strategy. The study aimed to explore the roles interaction DEAD-box helicase 21 (DDX21) cell division cycle 5-like (CDC5L) in colorectal (CRC) progression. Levels DDX21 CDC5L were detected lines by RT-qPCR Western blot assay. role on proliferation, tumor growth evaluated both vitro vivo. was predicted STRING publicly available data verified immunoprecipitation. results showed that...
We have previously reported that polysaccharides extracted from Pyracantha fortuneana (Maxim.) Li (P. fortuneana) lowered the oxidative stress and inhibited inflammatory responses in mice. Our present study aims to determine effects of Selenium enriched P. (Se-PFPs) against carbon tetrachloride (CCl4)-induced liver injury a mouse model. results displayed CCl4 remarkably elevated levels alanine transferase (ALT), aspartate transaminase (AST), lactic dehydrogenase (LDH), cholesterol,...
Cicada flower, scientifically named Cordyceps chanhua, is an important and well-known Chinese cordycipitoid medicinal mushroom. Although most mycoviruses seem to induce latent infections, some cause host effects. However, the effects of mycovirus on fungal development stress tolerance C. chanhua remain unknown. In this study, we report a novel designated partitivirus 1 (CchPV1) from isolate RCEF5997. The CchPV1 genome comprises dsRNA 2, 1784 1563 bp in length, respectively. Phylogenetic...
Elevated intraocular pressure (IOP) is the main risk factor for glaucoma, which might cause activation of astrocytes in optic nerve head. To determine effect mechanical stretch on astrocytes, we investigated changes cell phenotype, proteins interest and signaling pathways under biaxial stretch.The cultured rat head were stretched biaxially by 10 17% 24 h, respectively. Then, detected morphology, proliferation apoptosis cells, performed proteomics analysis. Protein expression was analyzed...
Bladder carcinoma (BLCA) is a common malignant tumor with high morbidity and mortality in the urinary system. Pyroptosis pattern of programmed cell death that closely associated progression tumors. Therefore, it significant to probe expression pyroptosis-related genes (PRGs) BLCA. The differentially expressed normal BLCA tissues were first obtained from Cancer Genome Atlas (TCGA) database analysis, as well PRGs National Center for Biotechnology Information (NCBI) database, intersecting...
Multiple myeloma (MM) remains a common hematologic malignancy with 10-year survival rate below 50%, which is largely due to disease relapse and resistance. The lack of simple practical approach establish patient-derived xenograft (PDX) hampers translational research. Here, we successfully developed PDXs by subcutaneous inoculation primary mononuclear cells from MM patients following series tumor tissue transplantations. Newly established retained essential cellular features recapitulated...
White matter injury is a predominant form of brain in preterm infants. However, effective drugs for its treatment are currently lacking. Previous studies have shown the neuroprotective effects Isoliquiritigenin (ISL), but impact on white infants remains poorly understood.