A5084895705- Gout, Hyperuricemia, Uric Acid
- Veterinary Equine Medical Research
- Reproductive Physiology in Livestock
- Testicular diseases and treatments
- Lipid metabolism and biosynthesis
- Advanced X-ray and CT Imaging
- Veterinary Oncology Research
- Venous Thromboembolism Diagnosis and Management
- Sperm and Testicular Function
- Veterinary Medicine and Surgery
- Cardiac Imaging and Diagnostics
- Musculoskeletal synovial abnormalities and treatments
- Circadian rhythm and melatonin
- Inflammation biomarkers and pathways
- Hematological disorders and diagnostics
- Sepsis Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Respiratory Support and Mechanisms
- Sports injuries and prevention
- Cholesterol and Lipid Metabolism
- Innovation, Technology, and Society
- Ultrasound in Clinical Applications
- Plant Toxicity and Pharmacological Properties
- Thermal Regulation in Medicine
- Heme Oxygenase-1 and Carbon Monoxide
German Center for Lung Research
2022-2024
Medizinische Hochschule Hannover
2022-2024
Innsbruck Medical University
2016-2024
University of Nebraska Medical Center
2021
Universität Innsbruck
2018
Institute of Early Childhood Research
2013
University of Tennessee at Knoxville
1984-1998
Knoxville College
1991
Hôpital Raymond-Poincaré
1989
To determine the association of cardiovascular atherosclerotic plaque monosodium urate deposits with occurrence major events in gout and hyperuricemia patients.
Monosodium uric acid (MSU) crystals may accumulate in the coronary plaque. The objective was to assess whether dual-energy computed tomography (DECT) allows for detection of MSU plaque.Patients were examined with 128-slice DECT applying a cardiac electrocardiogram-gated and peripheral extremity protocol. Patients divided into 3 groups: gout (tophi >1 cm joints), hyperuricemia (>6.5 mg/dL serum acid), controls. groups matched cardiovascular risk factors. acid-positive (+) calcified plaque...
Abstract Purpose To investigate the transcriptome of human bronchial epithelial cells (HBEC) in response to serum from patients with different degrees inflammation. Methods Serum 19 COVID-19 obtained Hannover Unified Biobank was used. At time sampling, 5 had a WHO Clinical Progression Scale (WHO-CPS) score 9 (severe illness). The remaining 14 WHO-CPS below (range 1–7), and lower illness. Multiplex immunoassay used assess inflammatory markers. culture medium HBEC supplemented 2% patient’s...
Pleural effusion, secondary to a metastasis from malignant hepatoblastoma, was diagnosed in 3-year-old Appaloosa gelding. Severe hemorrhagic transudate both pleural cavities resulted acute onset of labored breathing, tachypnea, tachycardia, and jugular vein pulsation. Results ultrasonography radiography the ventral lung field cranial portion abdomen initially were nondiagnostic, as results cytologic examination peritoneal fluid tracheal wash specimens. Moderately high serum gamma-glutamyl...
This report presents the results of 12 adult horses with 16 sarcoids which received radiotherapy from iridium‐192 interstitial implants. Fourteen tumors (87.5%) were in remission for at least months, and 13 (81.2%) 24 months. Generally, normal tissue reactions within acceptable limits. The this study further substantiate beneficial nature radioactive brachytherapy equine sarcold.
Dual-energy computed tomography (DECT) allows direct visualization of monosodium urate (MSU) deposits in joints and soft tissues.To describe the distribution MSU cadavers using DECT head, body trunk, feet.A total 49 (41 embalmed 8 fresh cadavers; 20 male, 29 female; mean age, 79.5 years; SD ± 11.3; range 52-95) unknown clinical history underwent to assess feet. Lens, thoracic aorta, foot tendon dissections were used verify by polarizing light microscopy.33/41 (80.5%) showed within aorta....
To highlight novel findings in the detection of monosodium urate deposits vessels using dual energy computed tomography, and to discuss potential clinical implications for gout hyperuricemia patients.
A modified bone‐flap technique was used to expose space occupying lesions that involved the conchofrontal sinus, ethmoturbinates, and caudal nasal cavity in five horses. The most common clinical findings were chronic discharge upper airway obstruction. Surgical intervention based on endoscopic radiographic interpretation. triangulated increased surgical exposure sinus by almost twice area observed previously described techniques. major advantages this allowed excellent visualization,...
Methotrexate (MTX) is well known to affect folic acid metabolism, so MTX treatment can result in alterations of mean corpuscular volume (MCV), which may impact on red cell distribution width (RDW), as MCV levels feed into RDW calculation. We thus questioned whether and subsequently its diagnostic utility RA subjects, reported before, are influenced by ongoing therapy. assessed the disease modifying drug (DMARD) treatment, especially MTX, evaluated their influence predictive value for...
Background Excessive inflammation, hemolysis, and accumulation of labile heme play an essential role in the pathophysiology multi-organ dysfunction syndrome (MODS) sepsis. Alpha1-antitrypsin (AAT), acute phase protein with binding capacity, is one modulators host responses to inflammation. In this study, we evaluate putative protective effect AAT against MODS mortality a mouse model polymicrobial abdominal Methods Polymicrobial sepsis was induced C57BL/6N mice by cecal ligation puncture...
A 62 year old man suddenly presented with a pure left sensory deficit involving only pain and temperature sensations. CT scan MRI showed small haemorrhage in the dorsolateral part of right midbrain. This suggested lesion limited to dorsal spinothalamic tract.
Aspermia was diagnosed in a 12-year-old Thoroughbred stallion with generalized lymphosarcoma. Invasion of the epididymus by neoplastic cells caused thickening and enlargement both epididymes. The testes were not affected. nodular ultrasonographic architecture similar to that previously reported cases infectious epididymitis.
Two stallions had unilateral bacterial epididymitis attributable to S zooepidemicus infection. Diagnosis was based on isolation, WBC in the semen, higher than normal blood fibrinogen concentration, and leukocytosis with regenerative left shift. One horse high seminal pH. Ultrasonography of involved epididymides revealed changes consistent appearance abnormal accumulation exudate tail epididymis. Treatment included orchiectomy antibiotic administration. In stallion 1, infection persisted...
A 9-year-old Arabian stallion with a 3-year history of infertility was evaluated for breeding soundness. Both testes were small. Ultrasonography revealed small amount free fluid between the tunics both testes. Results cytologic examination unremarkable. On semen examination, progressive motility 10%, and total number spermatozoa in ejaculate 6.6 x 10(9), which 92% abnormal. Predominant abnormalities head defects (75%): 57% heads had single or multiple vacuoles, 60% also midpiece swelling bending.
Bundesweit wurden in Deutschland 749 Eltern mit und ohne Migrationshintergrund zu ihren Erfahrungen zur erfahrenen Unterstutzung ihrem UIˆbergang eines Schulkindes interviewt. Aus den Ergebnissen werden diejenigen vorgestellt, die fur Frage relevant sind, inwieweit andere im Rahmen des Transitionsmanagements eine Ressource angehender sein koIˆnnen. Konsequenzen fuIˆr verstarkte Partizipation von Transitionsmanagement vorgestellt.
SUMMARY The effect of flunixin meglumine on renal function was studied in 6 healthy horses by use nonimaging nuclear medicine techniques. Effective plasma flow ( erpf ) and effective blood erbf were determined clearance 131 I-orthoiodohippuric acid before after administration meglumine. Mean 6.03 ml/min/kg 10.7 ml/min/kg, respectively, treatment 5.7 9.7 treatment. Although decreased administration, the difference not statistically significant.
A 7-year-old stallion with a history of abdominal pain after it fell was examined and found to have swelling the right testis epididymis. Semen evaluation revealed an increase in secondary sperm abnormalities. The unilaterally castrated. histologic diagnosis granuloma, no evidence infection. Periductal fibrosis observed appeared developed before trauma occurred. changes seen could be compatible chronic blockade efferent ductules, resulting extravasation spermatozoa.
Tissue hypoxia contributes to the pathogenesis of several acute and chronic diseases. Hyperbaric oxygen therapy (HBO) whole-body warming using low-temperature infrared technology (LIT) are techniques that might improve hypoxemia. Combining HBO LIT as hyperbaric combined with radiation (HBOIR) be an approach results in positive synergistic effects on oxygenation. increases blood flow could reduce HBO-induced vasoconstriction, hyperoxia compensate for increased metabolic requirements mediated...
Die Anämie ist eine häufige Komplikation der rheumatoiden Arthritis (RA). hat negative Auswirkungen auf den Verlauf RA und die Lebensqualität Patienten. Neben entzündungsabhängigen Veränderungen in Eisenhomöostase einer eingeschränkten biologischen Aktivität von Erythropoetin spielen auch Vitaminmangel, chronischer Blutverlust Nebenwirkungen RA-Therapeutika wichtige Rolle für Anämieentstehung. Aufgrund morbiditätsfördernden Effekte sollte diese als abklärungs- therapiebedürftige bei...
<h3>Background:</h3> Recently, monosodium urate (MSU) deposits were demonstrated in coronary arteries of 86.4% gout patients by dual energy computed tomography (DECT).[1] Cardiovascular (CV) MSU associated with major adverse cardiac events (MACE) [2], but also the presence peripheral increased risk for CV disease and death.[3] <h3>Objectives:</h3> The aim this retrospective analysis was to evaluate possible association 1) 2) MACE. <h3>Methods:</h3> We included all patients, recruited at...