A5055029029- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Virology and Viral Diseases
- HIV/AIDS Research and Interventions
- COVID-19 Impact on Reproduction
Madison Group (United States)
2023
University of Wisconsin–Madison
2022-2023
In the 2016 Zika virus (ZIKV) pandemic, a previously unrecognized risk of birth defects surfaced in babies whose mothers were infected with Asian-lineage ZIKV during pregnancy. Less is known about impacts gestational African-lineage infections. Given high human immunodeficiency (HIV) burdens regions where circulates, we evaluated whether pregnant rhesus macaques simian (SIV) have higher ZIKV-associated defects. Remarkably, both SIV+ and SIV- animals, infection early first trimester caused...
Spondweni virus (SPONV) is the closest known relative of Zika (ZIKV). SPONV pathogenesis resembles that ZIKV in pregnant mice, and both viruses are transmitted by Aedes aegypti mosquitoes. We aimed to develop a translational model further understand transmission pathogenesis. found cynomolgus macaques ( Macaca fascicularis ) inoculated with or were susceptible but resistant infection. In contrast, rhesus mulatta supported productive infection developed robust neutralizing antibody responses....
Abstract In the 2016 Zika virus (ZIKV) pandemic, a previously unrecognized risk of birth defects surfaced in babies whose mothers were infected with Asian-lineage ZIKV during pregnancy. Less is known about impacts gestational African-lineage infections. Given high human immunodeficiency (HIV) burdens regions where circulates, we evaluated whether pregnant rhesus macaques simian (SIV) have higher ZIKV-associated defects. Remarkably, both SIV+ and SIV-animals, infection early first trimester...
Abstract Spondweni virus (SPONV) is the closest known relative of Zika (ZIKV). SPONV pathogenesis resembles that ZIKV in pregnant mice, and both viruses are transmitted by Aedes aegypti mosquitoes. We aimed to develop a translational model further understand transmission pathogenesis. found cynomolgus macaques ( Macaca fascicularis ) inoculated with or were susceptible ZIKV, but resistant infection. In contrast, rhesus mulatta supported productive infection developed robust neutralizing...