Lauren E. Raasch
A5082664598- Mosquito-borne diseases and control
- COVID-19 Impact on Reproduction
- HIV/AIDS Research and Interventions
- Viral Infections and Vectors
- Virology and Viral Diseases
University of Wisconsin–Madison
2022-2023
Madison Group (United States)
2023
In the 2016 Zika virus (ZIKV) pandemic, a previously unrecognized risk of birth defects surfaced in babies whose mothers were infected with Asian-lineage ZIKV during pregnancy. Less is known about impacts gestational African-lineage infections. Given high human immunodeficiency (HIV) burdens regions where circulates, we evaluated whether pregnant rhesus macaques simian (SIV) have higher ZIKV-associated defects. Remarkably, both SIV+ and SIV- animals, infection early first trimester caused...
Countermeasures against Zika virus (ZIKV), including vaccines, are frequently tested in nonhuman primates (NHP). Macaque models important for understanding how ZIKV infections impact human pregnancy due to similarities placental development. The lack of consistent adverse outcomes ZIKV-affected pregnancies poses a challenge macaque studies where group sizes often small (4-8 animals). Studies animal suggest that African-lineage viruses can cause more frequent and severe fetal outcomes. No...
Countermeasures against Zika virus (ZIKV), including vaccines, are frequently tested in nonhuman primates (NHP). Macaque models important for understanding how ZIKV infections impact human pregnancy due to similarities placental development. The lack of consistent adverse outcomes ZIKV-affected pregnancies poses a challenge macaque studies where group sizes often small (4-8 animals). Studies animal suggest that African-lineage viruses can cause more frequent and severe fetal outcomes. No...
Abstract In the 2016 Zika virus (ZIKV) pandemic, a previously unrecognized risk of birth defects surfaced in babies whose mothers were infected with Asian-lineage ZIKV during pregnancy. Less is known about impacts gestational African-lineage infections. Given high human immunodeficiency (HIV) burdens regions where circulates, we evaluated whether pregnant rhesus macaques simian (SIV) have higher ZIKV-associated defects. Remarkably, both SIV+ and SIV-animals, infection early first trimester...