Alexandra J. Alberts
A5012345669- Mosquito-borne diseases and control
- Respiratory viral infections research
- Virology and Viral Diseases
- Viral Infections and Vectors
- HIV/AIDS Research and Interventions
- Bacteriophages and microbial interactions
- Viral gastroenteritis research and epidemiology
- COVID-19 Impact on Reproduction
University of Wisconsin–Madison
2022-2024
Madison Group (United States)
2023
In the 2016 Zika virus (ZIKV) pandemic, a previously unrecognized risk of birth defects surfaced in babies whose mothers were infected with Asian-lineage ZIKV during pregnancy. Less is known about impacts gestational African-lineage infections. Given high human immunodeficiency (HIV) burdens regions where circulates, we evaluated whether pregnant rhesus macaques simian (SIV) have higher ZIKV-associated defects. Remarkably, both SIV+ and SIV- animals, infection early first trimester caused...
Countermeasures against Zika virus (ZIKV), including vaccines, are frequently tested in nonhuman primates (NHP). Macaque models important for understanding how ZIKV infections impact human pregnancy due to similarities placental development. The lack of consistent adverse outcomes ZIKV-affected pregnancies poses a challenge macaque studies where group sizes often small (4-8 animals). Studies animal suggest that African-lineage viruses can cause more frequent and severe fetal outcomes. No...
Innovative methods for evaluating virus risk and spread, independent of test-seeking behavior, are needed to improve routine public health surveillance, outbreak response, pandemic preparedness. Throughout the COVID-19 pandemic, environmental surveillance strategies, including wastewater andair sampling, have been used alongside widespread individual-based SARS-CoV-2 testing programs provide population-level data. These strategies predominantly relied on pathogen-specific detection monitor...
Countermeasures against Zika virus (ZIKV), including vaccines, are frequently tested in nonhuman primates (NHP). Macaque models important for understanding how ZIKV infections impact human pregnancy due to similarities placental development. The lack of consistent adverse outcomes ZIKV-affected pregnancies poses a challenge macaque studies where group sizes often small (4-8 animals). Studies animal suggest that African-lineage viruses can cause more frequent and severe fetal outcomes. No...
Abstract In the 2016 Zika virus (ZIKV) pandemic, a previously unrecognized risk of birth defects surfaced in babies whose mothers were infected with Asian-lineage ZIKV during pregnancy. Less is known about impacts gestational African-lineage infections. Given high human immunodeficiency (HIV) burdens regions where circulates, we evaluated whether pregnant rhesus macaques simian (SIV) have higher ZIKV-associated defects. Remarkably, both SIV+ and SIV-animals, infection early first trimester...
Innovative methods for evaluating virus risk and spread, independent of test-seeking behavior, are needed to improve routine public health surveillance, outbreak response, pandemic preparedness. Throughout the COVID-19 pandemic, environmental surveillance strategies, including wastewater air sampling, have been used alongside widespread individual-based SARS-CoV-2 testing programs provide population-level data. These strategies predominantly relied on pathogen-specific detection monitor...