A5077597828- Respiratory viral infections research
- COVID-19 and Mental Health
- Down syndrome and intellectual disability research
- Health Policy Implementation Science
- COVID-19 and healthcare impacts
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 detection and testing
- Family and Disability Support Research
- Infection Control and Ventilation
- Ethics in Clinical Research
- Health, Environment, Cognitive Aging
- SARS-CoV-2 and COVID-19 Research
- Nosocomial Infections in ICU
- Antibiotic Use and Resistance
- Childhood Cancer Survivors' Quality of Life
- Infant Development and Preterm Care
- Health disparities and outcomes
- Pediatric health and respiratory diseases
- Antimicrobial Resistance in Staphylococcus
- Wireless Networks and Protocols
- Viral Infections and Outbreaks Research
- Food Security and Health in Diverse Populations
- Emergency and Acute Care Studies
Washington University in St. Louis
2021-2025
Office of Infectious Diseases
2023
Abstract Background In 2023, two highly effective forms of respiratory syncytial virus (RSV) immunoprophylaxis to prevent severe RSV disease in young children were approved: Abrysvo (vaccine pregnancy) and nirsevimab (infant monoclonal antibody). However, challenges with supply insurance reimbursement limited widespread availability during the 2023-2024 season.Table.Demographics NICU Infants Eligible for Immunoprophylaxis Methods From October 9, 2023 through March 31, 2024, all St. Louis...
Abstract Background The epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible S. (MSSA) infections in children has changed. In response to the introduction new antibiotics published clinical data, treatment strategies have evolved. objective this study is describe antimicrobial regimens for hospitalized with important pathogen.Table 1.Type Infections by MRSA vs. MSSA Methods A retrospective observational was performed using Pediatric Health...
Abstract Background Every year, up to 80,000 children less than 5 years are hospitalized due RSV infection and those 1 at greatest risk for ICU admission. In the Fall of 2023, 2 immunoprophylaxis strategies, nirsevimab infants Abrysvo pregnant women, were approved prevent serious in infants. This study investigates whether caregivers admitted with aware, had access vaccine was received.Table 1:RSV Respondents Demographics Methods A survey conducted among families born between April 2023...
Evidence suggests that coronavirus disease 2019 (COVID-19) testing in schools can add a layer of protection to reduce the spread Severe Acute Respiratory Syndrome Coronavirus 2 and facilitate safer return in-person learning. Despite this evidence, implementation school settings has been challenging initially because lack funding limited availability testing, but, as pandemic progressed more resources have devoted other challenges arisen. We describe key barriers strategies operationalized...
Abstract Background Transmission of SARS-CoV-2 in schools primarily for typically developing children is rare. However, less known about transmission with intellectual and developmental disabilities (IDD), who are often unable to mask or maintain social distancing. The objectives this study were determine positivity in-school rates using weekly screening tests school staff students describe the concurrent deployment mitigation strategies six IDD. Methods From November 23, 2020, May, 28,...
Schools provide important services that cannot be provided virtually to children with medical complexity and intellectual developmental disabilities, yet these are among the most at risk from coronavirus disease 2019 (COVID-19). To keep schools open for and/or disabilities during COVID-19 pandemic, we implemented severe acute respiratory syndrome 2 testing 3 sites across United States. We evaluated strategies staff students each site, including specimen source (nasopharyngeal or saliva),...
In April 2021, the US government made substantial investments in students' safe return to school by providing resources for school-based coronavirus disease 2019 (COVID-19) mitigation strategies, including COVID-19 diagnostic testing. However, testing uptake and access among vulnerable children with medical complexities remained unclear.
Students with intellectual and developmental disabilities (IDD) were disproportionately impacted by the COVID-19 pandemic. This study's goal was to assess effectiveness of 2 messaging strategies on participation in SARS-CoV-2 weekly testing.
Abstract BACKGROUNDTransmission of SARS-CoV-2 in schools primarily for typically developing children is rare. However, less known about transmission with intellectual and developmental disabilities (IDD), who are often unable to mask or maintain social distancing. The objectives this study were determine positivity in-school rates using weekly screening tests school staff students describe the concurrent deployment mitigation strategies six IDD.METHODSFrom 11/23/20 5/28/21, voluntary a high...
OBJECTIVES The Centers for Disease Control and Prevention recommend that schools can offer severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostic (on-demand) testing students staff with disease 2019 symptoms or exposures. Data related to the uptake, implementation, effect of school-associated on-demand have not been described. METHODS Rapid Acceleration Diagnostics Underserved Populations Return School program provided resources researchers implement SARS-CoV-2 in schools....
OBJECTIVES To provide recommendations for future common data element (CDE) development and collection that increases community partnership, harmonizes interpretation, continues to reduce barriers of mistrust between researchers underserved communities. METHODS We conducted a cross-sectional qualitative quantitative evaluation mandatory CDE among Rapid Acceleration Diagnostics-Underserved Populations Return School project teams with various priority populations geographic locations in the...
Individuals with intellectual and developmental disabilities are at increased risk for adverse outcomes from coronavirus disease 2019. Clusters of COVID-19 infections can be used to track SARS-CoV-2 transmission. This is particularly important in environments frequently individuals disabilities, such as schools. The objective this study was compare the number clusters student staff cases identified during three distinct periods (pre-Delta, Delta, Omicron) pandemic. Weekly testing occurred...
Abstract Background Participants of a COVID-19 school-based testing program in predominantly Black schools were asked to complete the NIH’s Common Data Elements (CDE) survey help understand demographic and social determinants health our population. The objective this study was assess if those completing CDEs reflective overall participants identify trusted sources these individuals Methods All offered opportunity 150 question CDE after being enrolled portion study. Descriptive statistics...
Abstract Background COVID-19 vaccination rates have been wide-ranging among age groups, specifically the pediatric population. Children under of 4 currently representing 12% with at least one dose, while children aged 5-11 represent 39% dose. We hypothesize that understanding and teaching caregivers will cause an increase in capability, opportunity motivation (COM-B Model) towards vaccine. Methods The study was conducted within St. Louis City County School Districts. Participants were...
Abstract Background COVID-19 vaccine uptake in the U.S. has been poor especially among children. We are conducting a study evaluating 2 theoretically informed strategies to increase uptake. Methods A sequential multiple assignment randomized trail (SMART) design is being conducted where participants into receiving text message with link resources or motivational interview (MI). After weeks, if person still not vaccinated, they re-randomized one of same two strategies. Participants were...
Abstract Background In-person learning is important for children with intellectual and developmental disabilities (IDD) because of the additional health, vocational, functional services students at these schools. It may be difficult to reduce SARS-CoV-2 transmission in IDD schools require assistance activities daily living such as eating, during which social distancing masking cannot occur. Surveillance testing cluster tracking IDD, considered high-risk environments transmissions, could have...