A5020443388- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Sinusitis and nasal conditions
- Streptococcal Infections and Treatments
- Bacterial Infections and Vaccines
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Head and Neck Surgical Oncology
- Adolescent and Pediatric Healthcare
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Otolaryngology and Infectious Diseases
- Childhood Cancer Survivors' Quality of Life
- SARS-CoV-2 detection and testing
- Child and Adolescent Health
- Neonatal and Maternal Infections
- Antifungal resistance and susceptibility
- Pediatric Urology and Nephrology Studies
- Urinary Tract Infections Management
- Viral gastroenteritis research and epidemiology
- Infective Endocarditis Diagnosis and Management
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and Mental Health
- Gut microbiota and health
- Global Health Care Issues
University of Wisconsin–Madison
2016-2025
University of Wisconsin Health
2022
University of Wisconsin American Family Children's Hospital
2021
Faculty of Public Health
2021
Children's Mercy Hospital
2021
UW Health University Hospital
1991-2016
Highland Community College - Illinois
2000
University of Rochester
1999
University of Minnesota
1995-1996
Abstract Asymptomatic bacteriuria (ASB) is a common finding in many populations, including healthy women and persons with underlying urologic abnormalities. The 2005 guideline from the Infectious Diseases Society of America recommended that ASB should be screened for treated only pregnant or an individual prior to undergoing invasive procedures. Treatment was not women; older men; diabetes, indwelling catheters, spinal cord injury. did address children some adult patients neutropenia, solid...
Abstract Asymptomatic bacteriuria (ASB) is a common finding in many populations, including healthy women and persons with underlying urologic abnormalities. The 2005 guideline from the Infectious Diseases Society of America recommended that ASB should be screened for treated only pregnant or an individual prior to undergoing invasive procedures. Treatment was not women; older men; diabetes, indwelling catheters, spinal cord injury. did address children some adult patients neutropenia, solid...
Virus is detected in about 80% of upper respiratory tract infections (URTIs) children and also detectable the nasopharynx 30% asymptomatic children. The effect viral infection on dynamics bacterial density colonization has not been reported. current study was performed to assess presence Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis 4–7-year-old during URTI when well. Nasal samples were obtained 4 surveillance periods whenever they had symptoms URTI. Respiratory...
Throughout the COVID-19 pandemic, masking has been a widely used mitigation practice in kindergarten through 12th grade (K-12) school districts to limit within-school transmission. Prior studies attempting quantify impact of have assessed total cases within schools; however, metric that more optimally defines effectiveness practices is transmission, or secondary cases. We estimated various on transmission cohort K-12 schools.
Upper respiratory infections (URI) and their complications are a major healthcare burden for pediatric populations. Although the microbiology of nasopharynx is an important determinant URI, little known nasopharyngeal (NP) microbiota children, factors that affect its composition, precise relationship with URI.Healthy children (n = 47) aged 49-84 months from prospective cohort study based in Wisconsin, USA, were examined. Demographic clinical data NP swab samples obtained participants upon...
Group A streptococcus (GAS) is responsible for 15%-30% of cases acute pharyngitis in children. Macrolides such as azithromycin have become popular treating GAS pharyngitis. We report macrolide resistance rates a primary care setting our geographic area over the past 5 years and discuss implications making treatment decisions. Throat swabs were collected from children with May 2011 to 2015 Madison, Wisconsin. Susceptibility testing was performed erythromycin clindamycin using Kirby-Bauer disk...
Abstract State the Purpose Obtaining high‐quality samples to diagnose streptococcal pharyngitis in pediatric patients is challenging due discomfort associated with traditional pharyngeal swabs. This may cause reluctance go clinic, inaccurate diagnosis, or inappropriate treatment for children sore throats. Here, we determined efficacy of CandyCollect, a lollipop‐inspired open‐microfluidic pathogen collection device, capture Group A Streptococcus (GAS) and compare user preference conventional...
The CandyCollect is a lollipop-inspired open-fluidic oral sampling device designed to provide comfortable user experience. We demonstrate that the can be coupled rapid antigen detection test (RADT) kit for Group A Streptococcus (GAS). Through in vitro experiments with pooled saliva spiked pyogenes, we tested various reagents and elution volumes optimize RADT readout from samples. resulting optimized protocol uses kit-provided lateral flow assay (LFA) while replacing kit's pharyngeal swab...
Rationale: Rhinovirus (RV) C can cause asymptomatic infection and respiratory illnesses ranging from the common cold to severe wheezing.Objectives: To identify how age other individual-level factors are associated with susceptibility RV-C illnesses.Methods: Longitudinal data COAST (Childhood Origins of Asthma) birth cohort study were analyzed determine relationships between infections. Neutralizing antibodies specific for RV-A (three types each) determined using a novel PCR-based assay. Data...
OBJECTIVES We evaluated the impact of distancing practices on secondary transmission severe acute respiratory syndrome coronavirus 2 and degree sports-associated across a large diverse cohort schools during spring 2021. METHODS Participating districts in North Carolina Wisconsin charter offering in-person instruction between March 15, 2021 June 25, reported policies, community- school-acquired infections, quarantines, infections associated with school-sponsored sports. calculated ratio to...
There has been a substantial change in the prevalence and microbiologic characteristics of cases acute otitis media secondary to widespread use pneumococcal conjugate vaccines. Current trends nasopharyngeal colonization microbiology support recommendation for antibiotic management bacterial sinusitis children.
Respiratory infections are common in children, and there is a need for user-friendly collection methods. Here, we performed the first human subjects study using CandyCollect device, lollipop-inspired saliva device .We showed that can be used to collect salivary bacteria from healthy adults Streptococcus mutans Staphylococcus aureus as proof-of-concept commensal bacteria. We enrolled nationwide (USA) remote which participants were sent packages containing devices traditional commercially...
Children with intellectual and developmental disabilities (IDDs) children medical complexity (CMC) have been disproportionally impacted by the coronavirus disease 2019 pandemic, including school closures. IDDs CMC rely on schools for a vast array of educational, therapeutic, medical, social needs. However, maintaining safe during pandemic may be difficult because unique challenges implementing prevention strategies, such as masking, distancing, hand hygiene in this high-risk environment....
Streptococcus pyogenes is a major human-specific bacterial pathogen and common cause of wide range symptoms from mild infection such as pharyngitis (commonly called strep throat) to life-threatening invasive post-infectious sequelae. Traditional methods for diagnosis include collecting sample using pharyngeal swab, which can discomfort even discourage adults children seeking proper testing treatment in the clinic. Saliva samples are an alternative swabs. To improve experience throat, we...
Acute bacterial sinusitis is a frequent complication of viral upper respiratory infection (URI). We describe the clinical and virologic features URIs that remain uncomplicated those precede an episode sinusitis. hypothesize certain viruses are more likely to lead acute sinusitis, we compare identified at time diagnosis with early in URI.Children aged 48-96 months were followed longitudinally for 1 year. Nasal samples obtained surveillance visits, on Day 3-4 URI, 10, when was diagnosed....
Abstract Rhinoviruses (RVs) can cause severe wheezing illnesses in young children and patients with asthma. Vaccine development has been hampered by the multitude of RV types little information about cross‐neutralization. We previously showed that neutralizing antibody (nAb) responses to RV‐C are detected twofold threefold more often than those RV‐A throughout childhood. Based on findings, we hypothesized infections likely induce either cross‐neutralizing or longer‐lasting compared...
Human parvovirus B19 infection is associated not only with erythema infectiosum (fifth disease) but also, rarely, purpuric or petechial rashes. Most reports of these atypical rashes describe sporadic cases skin lesions that have distinctively focal distributions. During a community outbreak fifth disease, we investigated cluster illnesses in children generalized to determine whether was the causative agent and, if so, more fully clinical spectrum are this virus.Systematic evaluation...