A5100321766- Renal Diseases and Glomerulopathies
- Genital Health and Disease
- Breast Cancer Treatment Studies
- Urological Disorders and Treatments
- Autoimmune Bullous Skin Diseases
- Systemic Lupus Erythematosus Research
- Cardiovascular Health and Risk Factors
- Cancer Diagnosis and Treatment
- Macrophage Migration Inhibitory Factor
- Stability and Control of Uncertain Systems
- RNA modifications and cancer
- Cell death mechanisms and regulation
- Mitochondrial Function and Pathology
- Iron Metabolism and Disorders
- Advanced biosensing and bioanalysis techniques
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- Immunodeficiency and Autoimmune Disorders
- Inflammasome and immune disorders
- Obesity, Physical Activity, Diet
- Cancer, Lipids, and Metabolism
- Adenosine and Purinergic Signaling
- Urologic and reproductive health conditions
- Natural Compounds in Disease Treatment
Beijing University of Chinese Medicine
2025
Wuhan University
2024
Nanyang Normal University
2024
Sun Yat-sen University
2024
Sun Yat-sen University Cancer Center
2024
Zhejiang University
2024
Zhongnan Hospital of Wuhan University
2024
Union Hospital
2008-2023
Fujian Medical University
2023
Hainan General Hospital
2013-2019
ABSTRACT Atopic dermatitis ( ad ) is a chronic inflammatory skin disease, with recent studies indicating that immune cells, such as monocytes and cytokines, play crucial role. By retrieving datasets from public databases analysing cell infiltration in lesional using CIBERSORT, we found M2 macrophages were significantly upregulated atopic dermatitis. Differentially expressed gene (DEG) functional enrichment analysis revealed cytokine‐cytokine receptor interaction was the most enriched...
The quality of water in urban parks is closely related to people's daily lives, but the pollution caused by microplastics park and sediments has not been comprehensively studied. Therefore, eight typical area Changsha, China, were selected, Raman spectroscopy was used explore spatial distributions compositions sediments, analyze their influencing factors, evaluate environmental risks. results showed that abundances surface all ranged from 150 525 n L
IgA nephropathy (IgAN) is the major cause of end-stage renal disease(ESRD) in Asia and its pathogenesis influenced by both genetic environmental factors. Single nucleotide polymorphisms (SNPs) IL1R1 IL-1R2 may be associated with susceptibility to IgAN. In this study, we study association between variants IL-1R1 risk Chinese Han population.In allelic model analysis, rs10490571 rs3917225 were a 1.40-fold, 1.31-fold increased nephropathy, respectively. was 1.46-fold IgAN dominant 1.36-fold...
Abstract It has been demonstrated that aldosterone (ALD) plays a direct profibrotic role in the kidney but underlying mechanism remains unclear. We examined of Rho kinase signal pathway epithelial–mesenchymal transition (EMT) process and extracellular matirx (ECM) synthesis induced by ALD human renal proximal tubular epithelial (HK‐2) cells vitro. collagen I, III protein expressions were detected ELISA. E‐cadherin, α‐smooth muscle actin (SMA), collagen_I mRNA real time PCR. α‐SMA measured...
IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide, but etiology and pathogenesis continue to be poorly understood. Polymorphisms in cytokine genes may play a role IgAN. The incidence different between diverse ethnic groups suggested important genetic influences on its pathogenesis. We genotype 10 single nucleotide polymorphisms (SNPs) IL-1B IL-6 gene using Sequenom Mass-ARRAY technology from 417 IgAN patients 463 healthy controls Chinese Han population....
Disturbances in hemostasis are common complications of kidney diseases and correlate well with cardiovascular mortality. Little is known about the effects fasudil on tissue factor (TF) plasminogen activator inhibitor-1 (PAI-1) expression peripheral blood mononuclear cells (PBMCs) CAPD patients. PBMCs were isolated from 13 individuals healthy subjects. After 4 h incubation or without LPS (10 ng/mL), TF PAI-1 mRNA detected by RT-PCR. The levels culture supernatants determined ELISA. Compared...
To prove whether astrocyte elevated gene-1 (AEG-1) plays a role in high glucose-stimulated Rho kinase activation and epithelial-mesenchymal transition (EMT) human renal tubular epithelial (HK-2) cells.The protein levels of AEG-1, alpha-smooth muscle actin, E-cadherin MYPT1 were determined by Western blot.AEG-1 level was upregulated HK-2 cells stimulated with glucose. AEG-1 siRNA downregulated expression blocked glucose-induced EMT.Our results show that acts key EMT cells.
Objective: To investigate the role of oxidative stress in human renal tubular epithelial cells (HK-2) induced by high glucose and underlying signal pathway vitro. Methods: MYPT1, pro-caspase-3, PGC-1α, Drp1 protein expressions were measured Western blot. MnSOD2, PGC-1α mRNA detected real time PCR. Results: Results showed that significantly up-regulated pro-caspase-3 expression MnSOD2 HK-2 cells; while Rho kinase inhibitor fasudil ROCK1 siRNA inhibited glucose. Importantly, markedly...
Marker code is an effective coding scheme to protect data from insertions and deletions. It has potential applications in future storage systems, such as DNA racetrack memory. When decoding marker codes, perfect channel state information (CSI), i.e., insertion deletion probabilities, are required detect errors. Sometimes, the CSI not easy obtain or accurate model unknown. Therefore, it deserved develop detecting algorithms for without knowledge of CSI. In this paper, we propose two...
The burden of premature atherosclerotic cardiovascular disease (ASCVD) has increased rapidly in China. Using the China Health and Nutrition Survey (CHNS) data, we assessed risk factors ASCVD (age diagnosis: <55 years for men <65 women). Propensity score matching was used to reduce selection bias. Multivariable Cox proportional-hazards analyses indicated that associated with included hypertension (adjusted hazard ratio [HR adj. ] = 1.68), obesity (HR 1.64), high carbohydrate intake...
Obesity is a major risk factor of hypertension, therefore quantifying the contribution obesity to hypertension necessary. The current study aimed investigate changes in population-attributable fractions (PAFs) associated with general and abdominal over recent 2 decades among US population, as well important sub-populations. This report was performed based on national-level cross-sectional data for 46,535 adults aged 18 years older 20,745 children 8–17 from National Health Nutrition...
Primary breast lymphoma (PBL) is a rare disease whose epidemiological features, treatment principles, and factors used for the patients' prognosis remain controversial.
The immunoregulatory effect of thalidomide on peripheral blood mononuclear cells in patients with thyroid-associated ophthalmopathy (TAO) was investigated.The resuhs showed that (50 μg/ml)inhibited the proliferation PBMC significantly.Thalidomide inhibitied tumor necrosis factor-α,IFN-γ,and interleukin-6 secretion,as well as mRNA expressions. Key words: Thalidomide; Thyroid-associated ophthalmopathy; Peripheral cell; Immunoregulatory
// Xiaohong Yang 1, * , Yin Zhang Wenning Li 1 Yan Su Dan Niu 2 Yanni Wang Haiyang Huang 3 Hui Han Daofa Maowei Xie Huiluan Wentan Xu and Jiali Wei Department of Nephrology, Hainan General Hospital, Haikou 570311, China The First Affiliated Hospital Xi’an Jiaotong University, 710061, Central Laboratory, These authors have contributed equally to this work Correspondence to: Wei, email: drjialiwei@163.com Keywords: IgA nephropathy (IgAN), MPHOSPH6, single nucleotide polymorphisms (SNPs),...
You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Penis/Testis/Urethra: Malignant Disease1 Apr 2015MP10-03 MODIFICATION OF N STAGING SYSTEMS FOR PENILE CANCER ¡a¡a BE MORE PRECISELY PREDICATIVE PROGNOSIS Kai Yao, Zaishang Li, Peng Chen, Fangjian Zhou, Zike Qin, Zhuowei Liu, Yonghong Pei Dong, and Hui Han YaoKai Yao More articles by this author , LiZaishang Li ChenPeng Chen ZhouFangjian Zhou QinZike Qin LiuZhuowei Liu LiYonghong DongPei Dong HanHui View All Author...
Objective To observe the treatment efficacy of atorvastatin for patients with different severities chronic obstructive pulmonary disease (COPD) in stable stage.To investigate timing statin therapy COPD.Methods Out-patients and inpatients COPD got into stage being treated at our hospital from February to May,2013 were chosen as study objects.There 40 cases each severity degree Ⅰ-Ⅳ.Patients randomly divided conventional groups (control groups) (treatment groups),with 20 group.The control group...
You have accessJournal of UrologyPenis/Testis/Urethra: Benign & Malignant Disease (II)1 Apr 2013756 INDEPENDENT EXTERNAL VALIDATION OF THE MOST RECENT NOMOGRAMS FOR PREDICTING LYMPH NODE METASTASIS IN PENILE CANCER Kai Yao, Hui Han, Jing Li, Fang-jian Zhou, Zi-ke Qin, and Zhuowei Liu YaoKai Yao Guangzhou, China, People's Republic More articles by this author , HanHui Han LiJing Li ZhouFang-jian Zhou QinZi-ke Qin LiuZhuowei View All Author...