A5046901166- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Vibrio bacteria research studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotics Pharmacokinetics and Efficacy
- Mycobacterium research and diagnosis
- Medication Adherence and Compliance
- Pneumonia and Respiratory Infections
- Liver Disease Diagnosis and Treatment
- Antimicrobial Resistance in Staphylococcus
- Syphilis Diagnosis and Treatment
- Health Education and Validation
- Antimicrobial agents and applications
- Bacterial Infections and Vaccines
- Biopolymer Synthesis and Applications
- Bacterial Identification and Susceptibility Testing
- SARS-CoV-2 and COVID-19 Research
- Genomics and Phylogenetic Studies
- Hepatitis B Virus Studies
- COVID-19 epidemiological studies
- Hepatitis C virus research
- Reproductive tract infections research
- Antibiotic Use and Resistance
- Evolution and Genetic Dynamics
- Reliability and Agreement in Measurement
Centro Hospitalar de Trás os Montes e Alto Douro
2020-2025
Hospital de São João
2020
Universidade Estadual de Campinas (UNICAMP)
2017
Pseudomonas aeruginosa causes urinary tract infections associated with catheters by forming biofilms on the surface of indwelling catheters. Therefore, controlling spread bacteria is crucial to preventing its transmission in hospitals and environment. Thus, our objective was determine antibiotic susceptibility profiles twenty-five P. isolates from UTIs at Medical Center Trás-os-Montes Alto Douro (CHTMAD). Biofilm formation motility are also virulence factors studied this work. Out isolates,...
The appearance of Klebsiella pneumoniae strains producing extended-spectrum β-lactamase (ESBL), and carbapenemase (KPC) has turned into a significant public health issue. ESBL- KPC-producing K. pneumoniae's ability to form biofilms is concern as it can promote the spread antibiotic resistance prolong infections in healthcare facilities. A total 45 were isolated from human infections. Antibiograms performed for 17 antibiotics, ESBL production was tested by Etest PM/PML, rapid test used detect...
Abstract Aims Antimicrobial resistance in P. aeruginosa represents a major global challenge public and veterinary health, particularly from One Health perspective. This study aimed to investigate antimicrobial resistance, the presence of virulence genes, genetic diversity isolates diverse sources. Methods Results The utilized susceptibility testing, genomic analysis for multilocus sequence typing characterize total 737 were collected humans, domestic animals, aquatic environments northern...
Klebsiella pneumoniae is a Gram-negative bacterium commonly associated with bloodstream infections (BSIs), which can lead to severe clinical outcomes, especially in immunocompromised individuals or patients underlying health conditions. The increasing prevalence of K. that produces extended-spectrum β-lactamases (ESBL) poses significant challenge for treatment and infection control, necessitating swift diagnostic approach tailored antimicrobial therapy improve patient outcomes. A total 32...
To provide, for the first time, data on molecular epidemiology of carbapenemase-producing Klebsiella pneumoniae clinical isolates from northern region Portugal (Trás-os-Montes and Alto Douro).A total 106 K. recovered samples rectal swabs between January 2018 March 2019 were included in this study. All characterized by antimicrobial susceptibility, identification resistance determinants, pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST), plasmid analysis.The most...
To analyse the epidemiology, resistome and virulome of ceftolozane/tazobactam-susceptible or -resistant Pseudomonas aeruginosa clinical isolates recovered from surveillance studies in Portugal (STEP, 2017-18) Spain (SUPERIOR, 2016-17).P. were intra-abdominal, urinary tract lower respiratory infections ICU patients admitted to 11 Portuguese 8 Spanish hospitals. MICs determined (ISO-standard broth microdilution, EUCAST 2020 breakpoints). A subset 28 ceftolozane/tazobactam-resistant P. analysed...
The evolutionary epidemiology, resistome, virulome and mobilome of thirty-one multidrug resistant Klebsiella pneumoniae clinical isolates from the northern Vila Real region Portugal were characterized using whole-genome sequencing bioinformatic analysis. genomic population structure was dominated by two main sequence types (STs): ST147 (n = 17; 54.8%) ST15 6; 19.4%) comprising four distinct clusters. Two carbapenemase coding genes detected (blaKPC-3 blaOXA-48) along with additional...
Genomic surveillance of SARS-CoV-2 in Portugal was rapidly implemented by the National Institute Health early stages COVID-19 epidemic, collaboration with more than 50 laboratories distributed nationwide.By applying recent phylodynamic models that allow integration individual-based travel history, we reconstructed and characterized spatio-temporal dynamics introductions dissemination Portugal.We detected at least 277 independent introductions, mostly from European countries (namely United...
Hepatitis C virus (HCV) core antigen (Ag) test has been increasingly applied as an effective alternative to conventional molecular tests allowing rapid and affordable diagnosis, which is of paramount relevance achieve global elimination HCV infection.ARCHITECT® Ag was evaluated in comparison with RNA quantification (CAP/CTM) calculate its sensitivity, specificity, positive predictive value (PPV), negative (NPV) determine their correlation level. Its performance, according low high viral load...
Pseudomonas aeruginosa and Klebsiella pneumoniae are notorious for their resistance to antibiotics propensity biofilm formation, posing significant threats human health. Epsilon-poly-L-lysine (ε-PL) emerges as a naturally occurring antimicrobial poly(amino acid), which positions it prospective agent addressing challenges linked multidrug resistance. ε-PL symbolizes promising avenue in the pursuit of efficacious therapeutic strategies warrants earnest consideration within realm clinical...
Pseudomonas aeruginosa is among the most ubiquitous bacteria in natural world, exhibiting metabolic and physiological versatility, which makes it highly adaptable. Imipenem + cilastatin tetracycline are antibiotic combinations commonly used to treat infections caused by P. aeruginosa, including serious such as sepsis. In context of bacterial infections, biofilm, formed cells surrounded extracellular substances forming a matrix, plays pivotal role resistance antibiotics. This study aimed...
ABSTRACT Purpose: to characterize the distribution and mechanisms involved in ceftolozane/tazobactam (C/T) resistance Pseudomonas aeruginosa isolates recovered from intensive care units (ICUs) Portugal as part of STEP surveillance study. Materials methods: a total 226 P. were collected patients with low respiratory tract infections (LRTI) admitted ICUs between June 2017 July 2018. Susceptibility antimicrobials including recent C/T combination was determined by EUCAST-criteria. Whole genome...
O teste de caminhada seis minutos - TC6’- é amplamente utilizado para avaliação da capacidade física e do prognóstico diversas doenças, em que a distância percorrida no TC6’ (DTC6’) uma das principais variáveis interpretá-lo. Vários estudos desenvolveram equações obter predita DPTC6’, porém as predição mais conhecidas na literatura foram desenvolvidas com indivíduos saudáveis. objetivo deste estudo foi analisar correlacionar DTC6’com DPTC6’ por meio Enright et al. Iwama pacientes doenças...