A5100644451- Neurological disorders and treatments
- Circadian rhythm and melatonin
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Gold and Silver Nanoparticles Synthesis and Applications
- Photosynthetic Processes and Mechanisms
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Frailty in Older Adults
- Colorectal Cancer Treatments and Studies
- DNA Repair Mechanisms
- Botulinum Toxin and Related Neurological Disorders
- PARP inhibition in cancer therapy
- Neuroblastoma Research and Treatments
- Advanced Radiotherapy Techniques
- Lung Cancer Treatments and Mutations
- Cardiovascular Syncope and Autonomic Disorders
- Transcranial Magnetic Stimulation Studies
- Photodynamic Therapy Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inflammatory Myopathies and Dermatomyositis
- Digital Radiography and Breast Imaging
- Laser-Ablation Synthesis of Nanoparticles
- Ferroptosis and cancer prognosis
- Cardiac and Coronary Surgery Techniques
Ruijin Hospital
2022-2025
Shanghai Jiao Tong University
2012-2025
Soochow University
2024
First Affiliated Hospital of Soochow University
2024
Tsinghua–Berkeley Shenzhen Institute
2022-2024
Tsinghua University
2022-2024
Nanjing Medical University
2023
Hunan Children's Hospital
2022
Children's Hospital of Fudan University
2021
Shandong University
2018
Uterine corpus endometrial carcinoma (UCEC) poses significant clinical challenges due to its high incidence and poor prognosis, exacerbated by the lack of effective screening methods. The standard treatment for UCEC typically involves surgical intervention, with radiation chemotherapy as potential adjuvant therapies. In recent years, immunotherapy has emerged a promising avenue advanced UCEC. This study employs multi-omics approach, analyzing RNA-sequencing data information from Cancer...
Abstract Background Frailty is associated with poor prognosis in a wide range of illnesses. However, its prognostic implications for older patients community-acquired pneumonia (CAP) are not adequately addressed. Methods In this study, were classified into 3 groups according to the frailty index based on standard laboratory tests (FI-Lab) score: robust (FI-Lab < 0.2), pre-frail 0.2–0.35), and frail ≥ 0.35). The relationships between all-cause mortality short-term clinical outcomes (length...
Triple Negative Breast Cancer (TNBC) is the most aggressive type of breast cancer (BC). Despite advances in clinical management TNBC, recurrence-related mortality remains a challenge. The stem-like phenotype TNBC plays significant role persistence minimal disease residue after therapy. Individuals exhibiting characteristics are particularly prone to inducing malignant relapse accompanied by strong resistance. Therefore, traits have been broadly proposed as therapeutic vulnerabilities treat...
Abstract Risk evaluation is ubiquitous in decisions. Deep brain stimulation of the subthalamic nucleus effective for Parkinson’s disease and obsessive–compulsive disorder, can be associated with impulsivity hypomania. Subthalamic has seemingly contrasting effects on enhancing conflict-induced but decreasing risk taking. Here, using a card gambling task paired intracranial recordings ( n = 25) within-subject case control acute 15) right nucleus, we dissociated objective uncertainty subjective...
Abstract Loss of phosphatase and tensin homolog (PTEN) impairs DNA double-strand repair confers sensitivity to poly (ADP-ribose) polymerase inhibitors (PARPis). However, PARPis also hyperactivate the MAPK PI3K/AKT/mTOR pathways in PTEN- deficient endometrial carcinoma (EC), which allows emergence PARPi resistance. BCL-2–associated death promoter (BAD), integrates common cell survival effects RAS/MEK/MAPK pathways. Herein, it was observed that increased BADSer99 (BADS99) phosphorylation EC...
Postural abnormalities (PA) are common in the advanced stages of Parkinson's disease (PD), but effective therapies lacking. A few studies suggested that spinal cord stimulation (SCS) could be a potential therapy whereas its effect is still uncertain. We aimed to investigate whether SCS had for benefiting PD patients with PA.
Abstract Background To identify the sensitivity, specificity, and overall diagnostic accuracy of infrared thermography in diagnosing lumbosacral radicular pain. Methods Patients sequentially presenting with lower extremity pain were enrolled. A clinical certainty score ranging from 0 to 10 was used assess likelihood pain, higher scores indicating likelihood. Infrared Thermography scans performed temperature difference (ΔT) calculated as ΔT = T1 - T2, where T2 represents skin most painful...
Poly (ADP-ribose) polymerase inhibitors (PARPis) have been approved for the treatment of recurrent epithelial ovarian cancer (EOC), regardless BRCA status or homologous recombination repair deficiency. However, low response platinum-resistant EOC, emergence resistance in BRCA-deficient cancer, and therapy-associated toxicities patients limit clinical utility PARPis EOC.The association phosphorylated (p) BADS99 with clinicopathological parameters survival outcomes an EOC cohort was assessed...
The radiosensitization of melanoma cells by gold nanorods
Frailty is a clinical syndrome and common phenomenon in the elderly, particularly when it coexists with chronic obstructive pulmonary disease (COPD). However, relationship between frailty its prognosis COPD patients has not been clearly elucidated.We collected electronic data of inpatients who were diagnosed First Affiliated Hospital Nanjing Medical University (NJMU) from January 2018 to December 2020. In further, we divided them into different groups based on Index Common Laboratory Tests...
We report a 44-year-old male with generalized progressive scleromyxoedema treated by total skin electron beam therapy (TSEBT) which produced marked improvement in the lesion. TSEBT can provide effective treatment for patients widespread involvement scleromyxoedema.
Atrial septal defect is one of the most common types congenital heart disease. This study aims to explore surgical and cosmetic effects open-heart surgery with right vertical axillary incision for simple disease in infants.From June 2018 October 2021, children who underwent direct atrial our department were selected a propensity score matched study. Those through included group. According age weight, matching method was employed match from group those undergoing median sternotomy (median...
Intraventricular baclofen has been reported as an alternative to intrathecal for managing refractory spasticity and dystonia in some circumstances. In this report, we described a frame-based stereotactic approach precisely positioning of the infusion catheter into third ventricle.
Abstract The traditional industrial electroplating parts manufacturing process typically relies on manual labour to suspend them in the tank, requiring a significant amount of work. However, due shortage manpower and frequent staff turnover, this has posed challenges production efficiency. Therefore, research proposes an automated mounting system by integrating machine vision technology development robotic arms replace conventional suspension method. initially separates individual...
Objective To quantify the setup errors measured with orthogonal megavoltage X-ray film in breast cancer patients immobilized bracket.To probe into margins from clinical target volume (CTV) to planning (PTV) 3 directions.Methods Repeat films were acquired for routine of fine verification 29 after conserving surgery,17 received whole radiation and 12 both supraclavicular node radiation.All supine position arms raised over their heads,using a personalized α-cradle (breast bracket).Registrations...
Changes of pulse transit time (PTT) induced by arm position were studied for unilateral arm. However, consistency the PTT changes was not validated both sides.We aimed to quantify between horizontal and non-horizontal positions from right left in order explore arms.Twenty-four normal subjects aged 21 50 (14 male 10 female) years enrolled. Left radial artery pulses synchronously recorded 24 healthy with one (left or right) at five angles (90∘, 45∘, 0∘, -45∘ -90∘) other level (0∘)...
Hydrogel Scaffolds In article number 2102837, Yongxiang Luo, Peng Huang, Jinwu Wang, and co-workers present a method for inducing controlled tumor angiogenesis by engineering the microenvironment. The interstitial flow direction regulates of capillary sprouting, while existence lung fibroblasts affects continuity lumen formation sprouted capillaries. vascularized model shows enhanced delivery anticancer drugs immune cells to spheroids through perfusable vascular networks.